The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Advances in Mass Spectrometry for Lipidomics
Abstract
Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification and quantification of molecular lipids in complex matrices. Although there are similarities between the field of lipidomics and the allied field of mass spectrometry (e.g., proteomics), lipids present some unique advantages and challenges for mass spectrometric analysis. The application of electrospray ionization to crude lipid extracts without prior fractionation—the so-called shotgun approach—is one such example, as it has perhaps been more successfully applied in lipidomics than in any other discipline. Conversely, the diverse molecular structure of lipids means that collision-induced dissociation alone may be limited in providing unique descriptions of complex lipid structures, and the development of additional, complementary tools for ion activation and analysis is required to overcome these challenges. In this article, we discuss the state of the art in lipid mass spectrometry and highlight several areas in which current approaches are deficient and further innovation is required.
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Cites
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Cited by
Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., Bonner, R., & Aebersold, R. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o111.016717 · Cited by 2,877
Shorthand notation for lipid structures derived from mass spectrometry
Liebisch, G., Vizcaíno, J. A., Köfeler, H., Trötzmüller, M., Griffiths, W. J., Schmitz, G., Spener, F., & Wakelam, M. J. O. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033506 · Cited by 833
Cajka, T., & Fiehn, O. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04491 · Cited by 830
Lipidomics for studying metabolism
Han, X. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.98 · Cited by 718
LipidXplorer: A Software for Consensual Cross-Platform Lipidomics
Herzog, R., Schuhmann, K., Schwudke, D., Sampaio, J. L., Bornstein, S. R., Schroeder, M., & Shevchenko, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029851 · Cited by 416
Metadata
- Authors
- Blanksby, S. J., & Mitchell, T. W.
- Venue
- Annual Review of Analytical Chemistry
- Publisher
- Annual Reviews
- Published
- 2010-06-01
- Volume
- 3
- Issue
- 1
- Pages
- 433-465
- ISSN
- 1936-1327 (ISSN-L)
- 1936-1335
- OpenAlex
- W2161210686
- Cited by
- 366
- References
- 113
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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