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Cited by 1,406

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THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS

Lichtenthaler, Hartmut K.·1999·Annual Review of Plant Physiology and Plant Molecular Biology

Abstract

▪ Abstract In plants the biosynthesis of prenyllipids and isoprenoids proceeds via two independent pathways: (a) the cytosolic classical acetate/mevalonate pathway for the biosynthesis of sterols, sesquiterpenes, triterpenoids; and (b) the alternative, non-mevalonate 1-deoxy-d-xylulose-5-phosphate (DOXP) pathway for the biosynthesis of plastidic isoprenoids, such as carotenoids, phytol (a side-chain of chlorophylls), plastoquinone-9, isoprene, mono-, and diterpenes. Both pathways form the active C 5-unit isopentenyl diphosphate (IPP) as the precursor from which all other isoprenoids are formed via head-to-tail addition. This review summarizes current knowledge of the novel 1-deoxy-d-xylulose-5-phosphate (DOXP) pathway for isopentenyl diphosphate biosynthesis, apparently located in plastids. The DOXP pathway of IPP formation starts from D-glyceraldehyde-3-phosphate (GA-3-P) and pyruvate, with DOXP-synthase as the starting enzyme. This pathway provides new insight into the regulation of chloroplast metabolism.

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Metadata

Authors
Lichtenthaler, H. K.
Venue
Annual Review of Plant Physiology and Plant Molecular Biology
Published
1999-06
Volume
50
Issue
1
Pages
47-65
ISSN
1040-2519 (ISSN-L)
OpenAlex
W2159958980
Cited by
1,406
References
2
FWCI
17.51
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS. https://app.cochat.ai/papers/10.1146/annurev.arplant.50.1.47
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Lichtenthaler, H. K. (1999). THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS. Annual Review of Plant Physiology and Plant Molecular Biology. https://doi.org/10.1146/annurev.arplant.50.1.47

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