The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Structural Insights into Microtubule Function
Abstract
▪ Abstract Microtubules are polymers that are essential for, among other functions, cell transport and cell division in all eukaryotes. The regulation of the microtubule system includes transcription of different tubulin isotypes, folding of α/β-tubulin heterodimers, post-translation modification of tubulin, and nucleotide-based microtubule dynamics, as well as interaction with numerous microtubule-associated proteins that are themselves regulated. The result is the precise temporal and spatial pattern of microtubules that is observed throughout the cell cycle. The recent high-resolution analysis of the structure of tubulin and the microtubule has brought new insight to the study of microtubule function and regulation, as well as the mode of action of antimitotic drugs that disrupt normal microtubule behavior. The combination of structural, genetic, biochemical, and biophysical data should soon give us a fuller understanding of the exquisite details in the regulation of the microtubule cytoskeleton.
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Citations
Cites
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Microtubules containing acetylated alpha-tubulin in mammalian cells in culture.
Piperno, G., LeDizet, M., & Chang, X. J. (1987) · The Journal of cell biology · doi:10.1083/jcb.104.2.289 · Cited by 873
Kin I kinesins are microtubule-destabilizing enzymes
Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80960-5 · Cited by 708
The Crystal Structure of Dimeric Kinesin and Implications for Microtubule-Dependent Motility
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An Essential Role for Katanin in Severing Microtubules in the Neuron
Ahmad, F. J., Yu, W., McNally, F. J., & Baas, P. W. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.2.305 · Cited by 253
How Taxol® stabilises microtubule structure
Amos, L. A., & Löwe, J. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)89002-4 · Cited by 248
Guillaud, L., Bosc, C., Fourest-Lieuvin, A., Denarier, E., Pirollet, F., Lafanechère, L., & Job, D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.167 · Cited by 132
Cited by
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1317 · Cited by 4,000
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
Mechanisms of Taxol resistance related to microtubules
Orr, G. A., Verdier-Pinard, P., McDaid, H., & Horwitz, S. B. (2003) · Oncogene · doi:10.1038/sj.onc.1206934 · Cited by 727
Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.053 · Cited by 696
Self-citationHow do anti-mitotic drugs kill cancer cells?
Gascoigne, K. E., & Taylor, S. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.039719 · Cited by 327
Metadata
- Authors
- Nogales, E.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2000-06
- Volume
- 69
- Issue
- 1
- Pages
- 277-302
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2105615050
- Cited by
- 782
- References
- 7
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
