Cited by 249Microtubule and mitosis dynamicsCancer Treatment and PharmacologySynthesis and biological activity

How Taxol® stabilises microtubule structure

Open access
Amos, Linda A, Löwe, Jan·1999·Chemistry & Biology

Abstract

The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

Integrity signals

Registry

Crossref · 10.1016/s1074-5521(99)89002-4

Cites

23 of 23 references verified0 citation errors · 0 not checkable

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  • The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.

    “The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.69,70”

    From Electronic energy migration in microtubules (2023) · cites this paper as [70]

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Authors
Amos, L. A., & Löwe, J.
Affiliations
MRC Laboratory of Molecular Biology (GB)
Venue
Chemistry & Biology
Publisher
Elsevier BV
Published
1999-03
Volume
6
Issue
3
Pages
R65-R69
ISSN
1074-5521 (ISSN-L)
OpenAlex
W2025691233
Cited by
248
References
24
Citations by year
2026: 5 · 2025: 9 · 2024: 1 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 11
FWCI
2.83
Type
journal article
Language
en
Open access
Locations
  • Chemistry & Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
Keywords
paclitaxel, microtubule stabilization, beta-tubulin, GTP hydrolysis, microtubule dynamics, drug binding sites
MeSH terms
Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Humans, Microtubules, Molecular Sequence Data, Protein Conformation, Paclitaxel

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