How Taxol® stabilises microtubule structure
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The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.
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The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.
“The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.69,70”
From Electronic energy migration in microtubules (2023) · cites this paper as [70]
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- Authors
- Amos, L. A., & Löwe, J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 6
- Issue
- 3
- Pages
- R65-R69
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2025691233
- Cited by
- 248
- References
- 24
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 1 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 11
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- paclitaxel, microtubule stabilization, beta-tubulin, GTP hydrolysis, microtubule dynamics, drug binding sites
- MeSH terms
- Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Humans, Microtubules, Molecular Sequence Data, Protein Conformation, Paclitaxel
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