Cited by 560Cellular transport and secretionReceptor Mechanisms and SignalingCaveolin-1 and cellular processes

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Clathrin

Kirchhausen, Tomas·2000·Annual Review of Biochemistry

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Abstract

▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified. The functional relationships among these disparate components remain, in many cases, obscure. High-resolution structures of parts of clathrin, determined by X-ray crystallography, and lower-resolution images of assembled coats, determined by electron cryomicroscopy, now provide the information necessary to integrate various lines of evidence and to design experiments that test specific mechanistic notions. This review summarizes and illustrates the recent structural results and outlines what is known about coated-vesicle assembly in the context of this information.

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Crossref · 10.1146/annurev.biochem.69.1.699

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Authors: Kirchhausen, T.
Affiliations: Harvard University (US)
Corresponding author: Kirchhausen, Tomas
ORCID: Kirchhausen, Tomas
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2000-06
Volume: 69
Issue: 1
Pages: 699-727
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.69.1.699
OpenAlex: W4251652273
Cited by: 560
References: 148
Citations by year: 2026: 15 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 22 · 2020: 12 · 2019: 10 · 2018: 22 · 2017: 12 · 2016: 17 · 2015: 12 · 2014: 22 · 2013: 28 · 2012: 17
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords: clathrin, clathrin-coated vesicles, endocytic receptor, X-ray crystallography, cryo-electron microscopy, endocytosis
MeSH terms: Amino Acid Sequence, Animals, Clathrin, Coated Pits, Cell-Membrane, Humans, Models, Molecular, Sequence Homology, Amino Acid, Protein Structure, Quaternary

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