The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dab2 links CIN85 with clathrin‐mediated receptor internalization
Abstract
CIN85 is a multidomain scaffold protein involved in downregulation of receptor tyrosine kinases. Here we show that disabled‐2 (Dab2), an endocytic adaptor molecule implicated in clathrin‐coat assembly, associates with CIN85 in mammalian cells. All three SH3 domains of CIN85 were able to bind to the PKPAPR peptide in the carboxyl‐terminal part of Dab2, possibly enabling CIN85 to simultaneously interact with multiple Dab2 molecules. CIN85 association with Dab2 is essential for its recruitment to clathrin coat and appears to be modulated by growth factor stimulation. Dab2 and clathrin dissociated from CIN85 following growth factor treatment, enabling other molecules, such as Cbl, to bind to CIN85. Taken together, our data indicate a dynamic interplay between CIN85 and its effectors during endocytosis of receptor tyrosine kinases.
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“Expression of Dab2 in polarized epithelial cells in developing circumventricular organs may be consistent with the well-documented functions of Dab2 in mediating endocytic trafficking of clathrin-coated vesicles [58,59], and in directing cell surface positioning [60].”
From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [59]
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Kirchhausen, T. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.699 · Cited by 560
Rice, D. S., Sheldon, M., D’Arcangelo, G., Nakajima, K., Goldowitz, D., & Curran, T. (1998) · Development · doi:10.1242/dev.125.18.3719 · Cited by 378
Disabled‐2 exhibits the properties of a cargo‐selective endocytic clathrin adaptor
Mishra, S. K., Keyel, P. A., Hawryluk, M. J., Agostinelli, N. R., Watkins, S. C., & Traub, L. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf487 · Cited by 302
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- 10.1083/jcb.200106056 · DOI
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- 10.1016/S0014-5793(02)03188-5 · DOI
- 10.1073/pnas.192462299 · DOI
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- 10.1093/emboj/21.7.1555 · DOI · Paper page
- 10.1034/j.1600-0854.2001.020206.x · DOI · Paper page
- 10.1016/S0962-8924(01)02043-8 · DOI · Paper page
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- 10.1074/jbc.M210628200 · DOI
- 10.1016/S0092-8674(02)00751-1 · DOI
- 10.1146/annurev.cellbio.17.1.517 · DOI
- 10.1034/j.1600-0854.2002.30503.x · DOI · Paper page
- 10.1038/sj.onc.1201678 · DOI
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- 10.1074/jbc.M110568200 · DOI
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Dynamic expression of Dab2 in the mouse embryonic central nervous system
Cheung, K.-K., Mok, S. C., Rezaie, P., & Chan, W. Y. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-76 · Cited by 23
Metadata
- Authors
- Kowanetz, K., Terzic, J., & Dikic, I.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-10-08
- Volume
- 554
- Issue
- 1-2
- Pages
- 81-87
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 37
- References
- 3
- Language
- en
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