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Transport of cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1

Matsudaira, Tatsuyuki, Niki, Takahiro, Taguchi, Tomohiko, Arai, Hiroyuki·2015·Journal of Cell Science
DOI 10.1242/jcs.172171
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Abstract

The retrograde pathway is defined by the transport of proteins and lipids from the plasma membrane (PM) through endosomes to the Golgi, and is essential for a variety of cellular activities. Recycling endosomes (REs) are important sorting stations for some retrograde cargo. SMAP2, an Arf GTPase-activating protein (GAP) for Arf1, with a putative clathrin-binding domain was previously shown to participate in the retrograde transport of CTxB from REs. Here we found that clathrin, a vesicle coat protein, and clathrin adaptor protein complex 1 (AP-1) were present at REs and were needed for the retrograde transport of cholera toxin B subunit (CTxB) from REs to the Golgi, but not from the PM to REs. SMAP2 immunoprecipitated clathrin/AP-1 through a putative clathrin-binding domain and a CALM-binding domain, and SMAP2 mutants that did not interact with clathrin/AP-1 could not localize to REs. Moreover, knockdown of Arf1 suppressed the retrograde transport of CTxB from REs to the Golgi. These findings suggest a clathrin-coated-vesicles-mediated retrograde transport from REs and the role of the coat proteins in the recruitment of Arf GAP to transport vesicles.

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  • AP-1 localizes to Rab11-positive recycling endosomes.

    “Since AP-1 has been shown to localize to Rab11-positive recycling endosomes [28], and ligand-stimulated EGFR is recycled back to the PM through Rab11-positive endosomes [29, 30], we examined if three molecules, EGFR, AP-1, and Rab11, could show colocalization in the cytoplasm.”

    From Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth (2021) · cites this paper as [28]

  • AP-1 localizes to Rab11-positive recycling endosomes, promoting retrograde transport of cholera toxin B-subunit from endosomes to the Golgi complex.

    “AP-1 has been shown to localize to Rab11-positive recycling endosomes, thereby promoting retrograde transport of the cholera toxin B-subunit from endosomes to the Golgi complex [28].”

    From Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth (2021) · cites this paper as [28]

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Metadata

Authors
Matsudaira, T., Niki, T., Taguchi, T., & Arai, H.
Affiliations
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2015-01-01
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.172171
Cited by
22
References
3
Language
en

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