Sphingosine 1-Phosphate Receptor Signaling

Principles of bioactive lipid signalling: lessons from sphingolipids

Hannun, Y. A., & Obeid, L. M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2329 · Cited by 3,411

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581

Sphingosine-1-phosphate: an enigmatic signalling lipid

Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,115

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

MANDALA, S. M., Hajdu, R., Bergstrom, J. D., Quackenbush, E. J., Xie, J., Milligan, J. A., Thornton, R. A., Shei, G.-J., Card, D., Keohane, C.-A., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,691

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E. E., Baumruker, T., HIESTAND, P. C., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200176200 · Cited by 1,512

GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Yao, X.-J., Weis, W. I., Stevens, R. C., et al. (2007) · Science · doi:10.1126/science.1150609 · Cited by 1,335

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,165

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,058

Sphingosine-1-phosphate (S1P) in ovarian physiology and disease

Hernández‐Coronado, C. G., Guzmán, A., Castillo‐Juárez, H., Zamora‐Gutiérrez, D., & Rosales‐Torres, A. M. (2019) · Annales d Endocrinologie · doi:10.1016/j.ando.2019.06.003 · Cited by 29

Biaryls

Yet, L. (2018) · Wiley eBooks · doi:10.1002/9781118686263.ch4 · Cited by 28

Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015)

Guerrero, M. A., Urbano, M., & Roberts, E. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1157165 · Cited by 27

Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer

Zeng, Y., Yao, X., Yan, Z., Liu, J., & Liu, X. (2016) · Oncology Letters · doi:10.3892/ol.2016.4661 · Cited by 27

S1P receptor modulators in Multiple Sclerosis: Detecting a potential skin cancer safety signal.

Stamatellos, V.-P., Rigas, A., Stamoula, E., Lallas, A., Papadopoulou, A., & Papazisis, G. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103681 · Cited by 24

Sphingosine 1-phosphate alleviates radiation-induced ferroptosis in ovarian granulosa cells by upregulating glutathione peroxidase 4

Zhao, J., Tang, M., Tang, H., Wang, M., Guan, H., Tang, L., & Zhang, H. (2022) · Reproductive Toxicology · doi:10.1016/j.reprotox.2022.12.002 · Cited by 27

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

Ledezma-Sánchez, B. A., García-Regalado, A., Guzmán-Hernández, M. L., & Vázquez‐Prado, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.108 · Cited by 27

Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma

Chiba, Y., Suzuki, K., Uechi, M., Kurihara, E., Goto, K., Sakai, H., & Misawa, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.05.005 · Cited by 27

Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1α

Zhang, Q., Bian, H., Guo, L., & Zhu, H. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500518 · Cited by 27

Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R−/−) mice

Potì, F., Bot, M., Costa, S., Bergonzini, V., Maines, L. W., Varga, G., Freise, H., Robenek, H., Simoni, M., & Nofer, J. (2012) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0583 · Cited by 27

The Impact of Bioactive Lipids on Cardiovascular Development

Kleger, A., Liebau, S., Lin, Q., von Wichert, G., & Seufferlein, T. T. W. (2011) · Stem Cells International · doi:10.4061/2011/916180 · Cited by 26

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity

Sibley, C. D., Morris, E. A., Kharel, Y., Brown, A. M., Huang, T., Bevan, D. R., Lynch, K. R., & Santos, W. L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01508 · Cited by 25

Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

Im, H., Park, J. H., Im, S., Han, J., Kim, K., & Lee, Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01314-w · Cited by 25

Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling

Gatfield, J., Monnier, L., Studer, R. O., Bolli, M. H., Steiner, B., & Nayler, O. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.03.029 · Cited by 26

Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells

Nomachi, A., Yoshinaga, M., Liu, J., Kanchanawong, P., Tohyama, K., Thumkeo, D., Watanabe, T., Narumiya, S., & Hirata, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082590 · Cited by 28

Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis

Jin, J., Hu, J., Zhou, W., Wang, X., Xiao, Q., Xue, N., Yin, D., & Chen, X. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.04.010 · Cited by 25

Lysophosphatidylcholine Drives Neuroblast Cell Fate

Paoletti, L., Domizi, P., Marcucci, H., Montaner, A., Krapf, D., Salvador, G. A., & Banchio, C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9528-0 · Cited by 22

Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma

Xu, Y., Dong, B., Wang, J., Zhang, J., Xue, W., & Huang, Y. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1502130 · Cited by 25

S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity

Zheng, H., Yu, J., Gao, L., Wang, K., Xu, Z., Zeng, Z., Zheng, K., Tang, X., Tian, X., Zhao, Q., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57124-x · Cited by 26

S1P2receptor promotes mouse skeletal muscle regeneration

Germinario, E., Peron, S., Toniolo, L., Betto, R., Cencetti, F., Donati, C., Bruni, P., & Danieli‐Betto, D. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00300.2012 · Cited by 24

Cross‐talk between sphingosine‐1‐phosphate and EGFR signaling pathways enhances human glioblastoma cell invasiveness

Cattaneo, M. G., Vanetti, C., Samarani, M., Aureli, M., Bassi, R., Sonnino, S., & Giussani, P. (2018) · FEBS Letters · doi:10.1002/1873-3468.13000 · Cited by 24

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

Philipp, S., Edelmann, B., Japtok, L., He, X., Hose, M., Hansen, W., Schuchman, E. H., Eckstein, A. K., & Berchner‐Pfannschmidt, U. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25466 · Cited by 24

The Organization of the Sphingosine 1-Phosphate Signaling System

Rosen, H., Sanna, M. G., Gonzalez‐Cabrera, P. J., & Roberts, E. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-05879-5_1 · Cited by 23

Validating a Selective S1P1 Receptor Modulator Syl930 for Psoriasis Treatment

Ji, M., Xue, N., Lai, F., Zhang, X., Zhang, S., Wang, Y., Jin, J., & Chen, X. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00939 · Cited by 23

S1P/S1P Receptor Signaling in Neuromuscolar Disorders

Meacci, E., & Garcia‐Gil, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246364 · Cited by 23

Sphingolipids and Metabolic Disease

Cowart, L. A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0650-1 · Cited by 23

Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720

Camp, S. M., Chiang, E. T., Sun, C., Usatyuk, P. V., Bittman, R., Natarajan, V., Garcia, J. G. N., & Dudek, S. M. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.08.004 · Cited by 23

Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells

Bendall, L. J., & Basnett, J. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283606090 · Cited by 22

Quantification of bioactive sphingo- and glycerophospholipid species by electrospray ionization tandem mass spectrometry in blood

Liebisch, G., & Scherer, M. (2011) · Journal of Chromatography B · doi:10.1016/j.jchromb.2011.10.037 · Cited by 22

Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry

Saigusa, D., Shiba, K., Inoue, A., Hama, K., Okutani, M., Iida, N., Saito, M., Suzuki, K., Kaneko, T., Suzuki, N., et al. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6004-9 · Cited by 22

Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis.

Mascall, K. S., Small, G. R., Gibson, G. A., & Nixon, G. F. (2012) · Journal of Cell Science · doi:10.1242/jcs.099044 · Cited by 22

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases

Kurata, H., Kusumi, K., Otsuki, K., Suzuki, R., Kurono, M., Komiya, T., Hagiya, H., Mizuno, H., Shioya, H., Ono, T., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00785 · Cited by 22

Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves

Witt, W., Jannasch, A., Burkhard, D., Christ, T., Ravens, U., Brunßen, C., Leuner, A., Morawietz, H., Matschke, K., & Waldow, T. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs002 · Cited by 21

Angiotensin II facilitates neointimal formation by increasing vascular smooth muscle cell migration: Involvement of APE/Ref-1-mediated overexpression of sphingosine-1-phosphate receptor 1

Lee, D.-Y., Won, K., Lee, K. P., Jung, S. H., Baek, S., Chung, H. W., Choi, W. S., Lee, H. M., Lee, B. H., Jeon, B. H., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.03.032 · Cited by 21

A benzo[b]thiophene-based selective type 4 S1P receptor agonist

Hur, W., Rosen, H., & Gray, N. S. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.11.050 · Cited by 21

Sphingosine 1‐phosphate attenuates neuronal dysfunction induced by amyloid‐β oligomers through endocytic internalization of NMDA receptors

Bigi, A., Cascella, R., Fani, G., Bernacchioni, C., Cencetti, F., Bruni, P., Chiti, F., Donati, C., & Cecchi, C. (2022) · FEBS Journal · doi:10.1111/febs.16579 · Cited by 20

4-Methoxy- N -[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P 1

Pennington, L. D., Sham, K. K. C., Pickrell, A. J., Harrington, P. E., Frohn, M. J., Lanman, B. A., Reed, A. B., Croghan, M. D., Lee, M. R., Xu, H., et al. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml2001399 · Cited by 20

Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum‐Depleted Culture: The Involvement of CREB Transcription Factor

Mizutani, N., Omori, Y., Tanaka, K., Ito, H., Takagi, A., Kojima, T., Nakatochi, M., Ogiso, H., Kawamoto, Y., Nakamura, M., et al. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25173 · Cited by 21

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Liu, H., Jackson, M. L., Goudswaard, L. J., Moore, S., Hutchinson, J. L., & Hers, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-94052-4 · Cited by 20

“Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720”

Camp, S. M., Chiang, E. T., Sun, C., Usatyuk, P. V., Bittman, R., Natarajan, V., Garcia, J. G. N., & Dudek, S. M. (2015) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2015.10.004 · Cited by 20

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)

Lanman, B. A., Cee, V. J., Cheruku, S. R., Frohn, M., Golden, J. E., Lin, J., Lobera, M., Marantz, Y., Muller, K. M., Neira, S., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml100228m · Cited by 19

Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells

Fan, A., Wang, Q., Yuan, Y., Cheng, J.-L., Chen, L., Guo, X., Li, Q., Chen, B., Huang, X., & Huang, Q. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00102.2015 · Cited by 19

Design, synthesis and docking-based 3D-QSAR study of novel 2-substituted 2-aminopropane-1,3-diols as potent and selective agonists of sphingosine-1-phosphate 1 (S1P1) receptor

Tian, Y., Jin, J., Wang, X., Han, W.-J., Li, G., Zhou, W., Xiao, Q., Qi, J., Chen, X., & Yin, D. (2013) · MedChemComm · doi:10.1039/c3md00079f · Cited by 18

Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation

Linke, B., Schreiber, Y., Zhang, D. D., Pierre, S. C., Coste, O., Henke, M., Suo, J., Fuchs, J., Angioni, C., Ferreiros-Bouzas, N., et al. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.06.002 · Cited by 18

Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P1 Receptor Modulator

Rey, M., Hess, P., Clozel, M., Delahaye, S., Gatfield, J., Nayler, O., & Steiner, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074285 · Cited by 18

Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism

Vogt, D., & Stark, H. (2016) · Medicinal Research Reviews · doi:10.1002/med.21402 · Cited by 19

Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling

Bian, G., Yu, C., Liu, L., Fang, C., Chen, K., Ren, P., Zhang, Q., Liu, F., Zhang, K., Xue, Q., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aat1470 · Cited by 18

Sphingosine lysolipids in the CNS: Endogenous cannabinoid antagonists or a parallel pain modulatory system?

Selley, D. E., Welch, S. P., & Sim‐Selley, L. J. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.06.004 · Cited by 17

Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity

Pennington, L. D., Croghan, M. D., Sham, K. K. C., Pickrell, A. J., Harrington, P. E., Frohn, M. J., Lanman, B. A., Reed, A. B., Lee, M. R., Xu, H., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.10.085 · Cited by 18

Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core

Harrington, P. E., Croghan, M. D., Fotsch, C. H., Frohn, M., Lanman, B. A., Pennington, L. D., Pickrell, A. J., Reed, A. B., Sham, K. K. C., Tasker, A. S., et al. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200252b · Cited by 17

H9N2 avian influenza infection altered expression pattern of Sphiogosine-1-phosphate Receptor 1 in BALB/c mice

Tong, S., Tian, J., Wang, H., Huang, Z., Yu, M., Sun, L., Liu, R., Liao, M., & Ning, Z. (2013) · Virology Journal · doi:10.1186/1743-422x-10-296 · Cited by 18

Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors

Li, H., Sibley, C. D., Kharel, Y., Huang, T., Brown, A. M., Wonilowicz, L. G., Bevan, D. R., Lynch, K. R., & Santos, W. L. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115941 · Cited by 17

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists

Meng, Q., Zhao, B., Xu, Q., Xu, X., Deng, G., Li, C., Luan, L., Ren, F., Wang, H., Xu, H., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.02.083 · Cited by 16

Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule

Hartney, J. M., Gustafson, C. E., Bowler, R. P., Pelanda, R., & Torres, R. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.282772 · Cited by 16

Expansion of Hydra actinoporin-like toxin (HALT) gene family: Expression divergence and functional convergence evolved through gene duplication

Yap, W. Y., Tan, K. J. S. X., & Hwang, J. S. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.09.007 · Cited by 13

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor

Li, C., Chi, X. X., Xie, W., Strong, J. A., Zhang, J.-M., & Nicol, G. D. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00825.2011 · Cited by 16

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands

Luo, Z., Yue, X., Yang, H., Liu, H., Klein, R. S., & Tu, Z. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.12.010 · Cited by 16

Ca2+ Signaling Induced by Sphingosine 1-Phosphate and Lysophosphatidic Acid in Mouse B Cells

Nam, J., Shin, D. H., Min, J. E., Ye, S., Jeon, J., & Kim, S. J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0020-4 · Cited by 16

Deciphering the role of sphingosine 1‐phosphate in central nervous system myelination and repair

Binish, F., & Xiao, J. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16228 · Cited by 17

Sphingosine 1-phosphate receptor 1 modulators exert neuroprotective effects in central nervous system disorders

Chen, S., Wu, L., Lang, B., Zhao, G., & Zhang, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1516991 · Cited by 16

Novel functions of S1P in chronic itchy and inflammatory skin diseases

Gray, N., Limberg, M. M., Bräuer, A. U., & Raap, U. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17764 · Cited by 15

Photoreactive bioorthogonal lipid probes and their applications in mammalian biology

Shanbhag, K., Sharma, K., & Kamat, S. S. (2022) · RSC Chemical Biology · doi:10.1039/d2cb00174h · Cited by 17

Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity

Sun, Y., Tian, Y., Wu, S., Huang, A., Hu, Y., Liao, Z., Swift, M. L., Deng, S., Yang, X., Zhang, B., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101303 · Cited by 15

Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design

Tian, Y., Jin, J., Wang, X., Hu, J., Xiao, Q., Zhou, W., Chen, X., & Yin, D. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.081 · Cited by 15

Extracellular molecules in hematopoietic stem cell mobilisation

Bendall, L. J. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2123-y · Cited by 15

Effects of chemotherapy agents on Sphingosine-1-Phosphate receptors expression in MCF-7 mammary cancer cells

Ghosal, P. K., Sukocheva, O. A., Wang, T., Mayne, G. C., Watson, D. I., & Hussey, D. J. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.04.016 · Cited by 15

Sphingosine 1-phosphate-induced nitric oxide production simultaneously controls endothelial barrier function and vascular tone in resistance arteries

Kerage, D., Gombos, R. B., Wang, S., Brown, M. A., & Hemmings, D. G. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106874 · Cited by 13

Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor

van Loenen, P. B., de Graaf, C., Verzijl, D., Leurs, R., Rognan, D., Peters, S. L. M., & Alewijnse, A. E. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.071 · Cited by 14

Structure-activity relationship studies and bioactivity evaluation of 1,2,3-triazole containing analogues as a selective sphingosine kinase-2 inhibitors

Tangadanchu, V. K. R., Jiang, H., Yu, Y., Graham, T. J. A., Liu, H., Rogers, B. E., Gropler, R. J., Perlmutter, J. S., & Tu, Z. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112713 · Cited by 14

Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines

Furuya, K., Hirata, H., Kobayashi, T., & Sokabe, M. (2021) · Life · doi:10.3390/life11080851 · Cited by 12

The influence of sphingosine-1-phosphate receptor antagonists on gentamicin-induced hair cell loss of the rat cochlea

Nakayama, M., Tabuchi, K., Hoshino, T., Nakamagoe, M., Nishimura, B., & Hara, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.063 · Cited by 14

S1P3receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle

Germinario, E., Bondı̀, M., Cencetti, F., Donati, C., Nocella, M., Colombini, B., Betto, R., Bruni, P., Bagni, M. A., & Danieli‐Betto, D. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00345.2015 · Cited by 14

Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition

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