Sphingosine 1-Phosphate Receptor Signaling

Principles of bioactive lipid signalling: lessons from sphingolipids

Hannun, Y. A., & Obeid, L. M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2329 · Cited by 3,411

High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor

Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581

Sphingosine-1-phosphate: an enigmatic signalling lipid

Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,115

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

MANDALA, S. M., Hajdu, R., Bergstrom, J. D., Quackenbush, E. J., Xie, J., Milligan, J. A., Thornton, R. A., Shei, G.-J., Card, D., Keohane, C.-A., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,691

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E. E., Baumruker, T., HIESTAND, P. C., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200176200 · Cited by 1,512

GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function

Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Yao, X.-J., Weis, W. I., Stevens, R. C., et al. (2007) · Science · doi:10.1126/science.1150609 · Cited by 1,335

CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,165

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,058

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628

Dietary metabolism, the gut microbiome, and heart failure

Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., & Rosen, H. (2011) · Cell · doi:10.1016/j.cell.2011.08.015 · Cited by 688

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Chongsathidkiet, P., Jackson, C., Koyama, S., Loebel, F., Cui, X., Farber, S. H., Woroniecka, K. I., Elsamadicy, A. A., Dechant, C. A., Kemeny, H. R., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0135-2 · Cited by 675

Crystal Structure of a Lipid G Protein–Coupled Receptor

Hanson, M. A., Roth, C., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G. J., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., et al. (2012) · Science · doi:10.1126/science.1215904 · Cited by 662

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

Komarova, Y. A., & Malik, A. B. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135833 · Cited by 640

Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis

Sandborn, W. J., Feagan, B. G., Wolf, D. C., D’Haens, G., Vermeire, S., Hanauer, S. B., Ghosh, S. K., Smith, H., Cravets, M. W., Frohna, P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513248 · Cited by 451

An update on sphingosine-1-phosphate and other sphingolipid mediators

Fyrst, H., & Saba, J. D. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.392 · Cited by 350

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

Kajimoto, T., Okada, T., Miya, S., Zhang, L., & Nakamura, S. (2013) · Nature Communications · doi:10.1038/ncomms3712 · Cited by 332

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

McGinley, M., & Cohen, J. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00244-0 · Cited by 320

Regulation of sphingosine kinase and sphingolipid signaling

Pitson, S. M. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.08.001 · Cited by 314

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

Breslow, D. K., & Weissman, J. S. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.005 · Cited by 303

Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial

Comı, G., Kappos, L., Selmaj, K. W., Bar‐Or, A., Arnold, D. L., Steinman, L., Hartung, H., Montalbán, X., Havrdová, E., Cree, B., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30239-x · Cited by 297

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

Wang, X., He, Q., Zhou, C., Xu, Y., Liu, D., Fujiwara, N., Kubota, N., Click, A., Henderson, P., Vancil, J., et al. (2023) · Immunity · doi:10.1016/j.immuni.2022.11.013 · Cited by 262

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

Vu, M. T., Ishizu, A.-N., Foo, J. C., Toh, X. R., Zhang, F., Whee, D. M., Torta, F. T., Cazenave‐Gassiot, A., Matsumura, T., Kim, S., et al. (2017) · Nature · doi:10.1038/nature24053 · Cited by 241

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

Rosen, H., Stevens, R. C., Hanson, M. A., Roberts, E., & Oldstone, M. B. A. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062411-130916 · Cited by 231

Intestinal absorption of bile acids in health and disease

Ticho, A. L., Malhotra, P., Dudeja, P. K., Gill, R. K., & Alrefai, W. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190007 · Cited by 215

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

Hisano, Y., Kobayashi, N., Yamaguchi, A., & Nishi, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038941 · Cited by 219

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

Lovric, S., Gonçalves, S., Gee, H. Y., Oskouian, B., Srinivas, H., Choi, W., Shril, S., Ashraf, S., Tan, W., Rao, J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89626 · Cited by 209

Interaction of G protein coupled receptors and cholesterol

Gimpl, G. (2016) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2016.04.006 · Cited by 202

Enhancement of Neoangiogenesis and Follicle Survival by Sphingosine-1-Phosphate in Human Ovarian Tissue Xenotransplants

Soleimani, R., Heytens, E., & Oktay, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019475 · Cited by 197

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

Ali, O., & Szabó, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115693 · Cited by 223

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

Chi, H. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.002 · Cited by 184

Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function

Serra, M., & Saba, J. D. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.10.024 · Cited by 183

Safety and efficacy of the selective sphingosine 1-phosphate receptor modulator ozanimod in relapsing multiple sclerosis (RADIANCE): a randomised, placebo-controlled, phase 2 trial

Cohen, J. A., Arnold, D. L., Comi, G., Bar‐Or, A., Gujrathi, S., Hartung, J. P., Cravets, M., Olson, A. D., Frohna, P., & Selmaj, K. W. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00018-1 · Cited by 177

Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns

Park, S.-J., Kim, J. M., Kim, J., Hur, J., Park, S., Kim, K. H., Shin, H., & Chwae, Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811432115 · Cited by 182

New Therapeutics for Ulcerative Colitis

Hirten, R. P., & Sands, B. E. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-052919-120048 · Cited by 177

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

Pan, S., Gray, N. S., Gao, W., Mi, Y., Fan, Y., Wang, X., Tuntland, T., Che, J., Lefebvre, S., Chen, Y. A., et al. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300396r · Cited by 173

Roles, regulation and inhibitors of sphingosine kinase 2

Neubauer, H. A., & Pitson, S. M. (2013) · FEBS Journal · doi:10.1111/febs.12314 · Cited by 171

Sphingosine‐1‐phosphate receptor 1 signalling in T cells: trafficking and beyond

Garris, C., Blaho, V. A., Hla, T., & Han, M. H. (2014) · Immunology · doi:10.1111/imm.12272 · Cited by 166

Next generation of small molecules in inflammatory bowel disease

Olivera, P., Danese, S., & Peyrin-Biroulet, L. (2017) · Gut · doi:10.1136/gutjnl-2016-312912 · Cited by 154

Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis

Karlsson, G., Francis, G., Koren, G., Heining, P., Zhang, X., Cohen, J. A., Kappos, L., & Collins, W. (2014) · Neurology · doi:10.1212/wnl.0000000000000137 · Cited by 157

Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery

Chen, T., Xiong, H., Yang, J., Zhu, X., Qu, R., & Yang, G. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03369 · Cited by 158

Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist

Murakami, A., Takasugi, H., Ohnuma, S., Koide, Y., Sakurai, A., Takeda, S., Hasegawa, T., Sasamori, J., Konno, T., Hayashi, K., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.061481 · Cited by 152

T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation

Feng, H., Stachura, D. L., White, R. M., Gutiérrez, A., Zhang, L., Sanda, T., Jette, C. A., Testa, J. R., Neuberg, D. S., Langenau, D. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.09.009 · Cited by 150

Lysophospholipid Mediators in Health and Disease

Kano, K., Aoki, J., & Hla, T. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-050420-025929 · Cited by 161

Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism

Kwong, E. K., Li, Y., Hylemon, P. B., & Zhou, H. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.12.009 · Cited by 152

Fingolimod modulates microglial activation to augment markers of remyelination

Jackson, S. J., Giovannoni, G., & Baker, D. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-76 · Cited by 145

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

Ceccom, J., Loukh, N., Lauwers‐Cancès, V., Touriol, C., Nicaise, Y., Gentil, C., Uro‐Coste, E., Pitson, S. M., Maurage, C., Duyckaerts, C. J., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-12 · Cited by 140

A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

Abuhusain, H. J., Matin, A., Qiao, Q., Shen, H. M., Kain, N., Day, B. W., Stringer, B. W., Daniels, B. J., Laaksonen, M. A., Teo, C., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.494740 · Cited by 132

G protein-coupled receptors as promising cancer targets

Liu, Y., An, S., Ward, R. J., Yang, Y., Guo, X., Li, W., & Xu, T. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.031 · Cited by 134

A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD

Chudy‐Onwugaje, K., Christian, K. E., Farraye, F. A., & Cross, R. K. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy327 · Cited by 131

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

van Doorn, R., Nijland, P. G., Dekker, N., Witte, M. E., Pinheiro, M. A. L., Hof, B. V. H., Kooij, G., Reijerkerk, A., Dijkstra, C. D., van der Valk, P., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1014-4 · Cited by 125

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

Mehling, M., Johnson, T., Antel, J. P., Kappos, L., & Bar‐Or, A. (2011) · Neurology · doi:10.1212/wnl.0b013e31820db341 · Cited by 128

Decreased plasma concentrations of apolipoprotein M in sepsis and systemic inflammatory response syndromes

Kumaraswamy, S. B., Linder, A., Åkesson, P., & Dahlbäck, B. (2012) · Critical Care · doi:10.1186/cc11305 · Cited by 125

Actin polymerization‐enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP

Cheng, Y., Feng, Y., Jansson, L., Sato, Y., Deguchi, M., Kawamura, K., & Hsueh, A. J. W. (2015) · The FASEB Journal · doi:10.1096/fj.14-267856 · Cited by 123

Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus

Kanno, T., Nishizaki, T., Proia, R. L., Kajimoto, T., Jahangeer, S. M., Okada, T., & Nakamura, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.021 · Cited by 111

The Selective Sphingosine 1-Phosphate Receptor 1 Agonist Ponesimod Protects against Lymphocyte-Mediated Tissue Inflammation

Piali, L., Froidevaux, S., Hess, P., Nayler, O., Bolli, M. H., Schlosser, E., Kohl, C., Steiner, B., & Clozel, M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.176487 · Cited by 110

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-β autocrine loop

Zeng, Y., Yao, X., Chen, L., Yan, Z., Liu, J., Zhang, Y., Feng, T., Wu, J., & Liu, X. (2016) · Oncotarget · doi:10.18632/oncotarget.11450 · Cited by 108

Endothelial Functions of Sphingosine-1-phosphate

Lucke, S., & Levkau, B. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000315109 · Cited by 104

Gut microbiome - A potential mediator of pathogenesis in heart failure and its comorbidities: State-of-the-art review

Mamic, P., Chaikijurajai, T., & Tang, W. H. W. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.12.001 · Cited by 100

The Role of Sphingosine-1-Phosphate Transporter Spns2 in Immune System Function

Nijnik, A., Clare, S., Hale, C., Chen, J., Raisen, C. L., Mottram, L., Lucas, M., Estabel, J., Ryder, E., Adissu, H. A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200282 · Cited by 100

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Rutherford, C., Childs, S., Ohotski, J., McGlynn, L. M., Riddick, M., Macfarlane, S. R., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.455 · Cited by 100

Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3–Gαq coupling

Kim, E.-S., Kim, J.-S., Kim, S. G., Hwang, S., Lee, C. H., & Moon, A. (2011) · Journal of Cell Science · doi:10.1242/jcs.076794 · Cited by 93

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

Nußbaum, C., Bannenberg, S., Keul, P., Gräler, M. H., Gonçalves-de-Albuquerque, C. F., Korhonen, H., Lipinski, K. V. W., Heusch, G., Neto, H. C. D. C. F., Rohwedder, I., et al. (2015) · Nature Communications · doi:10.1038/ncomms7416 · Cited by 98

Inflammatory and microenvironmental factors involved in breast cancer progression

Ham, M., & Moon, A. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0271-7 · Cited by 95

Endocytosis of lipoproteins

Zanoni, P., Velagapudi, S., Yalçınkaya, M., Rohrer, L., & von Eckardstein, A. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.06.881 · Cited by 97

Sphingosine 1-Phosphate (S1P) Regulates Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells

Cantrell, J. E. L., Morris, A. J., Sunkara, M., Popa, G. J., Larson, K., & Özcan, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.268185 · Cited by 94

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD

Awojoodu, A. O., Keegan, P. M., Lane, A. R., Zhang, Y., Lynch, K. R., Platt, M. O., & Botchwey, E. A. (2014) · Blood · doi:10.1182/blood-2014-01-543652 · Cited by 93

Cytokine Storm Plays a Direct Role in the Morbidity and Mortality from Influenza Virus Infection and is Chemically Treatable with a Single Sphingosine-1-Phosphate Agonist Molecule

Oldstone, M. B. A., & Rosen, H. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-05879-5_6 · Cited by 85

Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases

Schwalm, S. A., Pfeilschifter, J. M., & Huwiler, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.07.022 · Cited by 84

Intravasation as a Key Step in Cancer Metastasis

Zavyalova, M. V., Denisov, E. V., Таширева, Л. А., Savelieva, O. E., Кайгородова, Е. В., Krakhmal, N. V., & Михайлович, П. В. (2019) · Biochemistry (Moscow) · doi:10.1134/s0006297919070071 · Cited by 86

G protein‐coupled receptors: the inside story

Jalink, K., & Moolenaar, W. H. (2009) · BioEssays · doi:10.1002/bies.200900153 · Cited by 79

Osteoblast‐derived sphingosine 1‐phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis‐derived prostate cancer cells

Brizuela, L., Martin, C., Jeannot, P., Ader, I., Gstalder, C., Andrieu, G. P., Bocquet, M., Laffosse, J., Gomez‐Brouchet, A., Malavaud, B. A., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.04.001 · Cited by 81

Ocean Acidification Affects Redox-Balance and Ion-Homeostasis in the Life-Cycle Stages of Emiliania huxleyi

Rokitta, S. D., John, U., & Rost, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052212 · Cited by 75

Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells

Kennedy, A. J., Mathews, T. P., Kharel, Y., Field, S. D., Moyer, M. L., East, J. E., Houck, J. D., Lynch, K. R., & Macdonald, T. L. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2001053 · Cited by 74

Role of the microbiota–gut–heart axis between bile acids and cardiovascular disease

Zhang, Z., Lv, T., Wang, X., Wu, M., Zhang, R., Yang, X., Fu, Y., & Liu, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116567 · Cited by 79

G-Protein-Coupled Receptors in Adult Neurogenesis

Doze, V. A., & Perez, D. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.004762 · Cited by 75

Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling

Wang, Y., Tsai, C., Chuang, H.-L., Chang, Y., Chen, H., Lee, J.-N., & Tsai, E. (2016) · Oncotarget · doi:10.18632/oncotarget.9007 · Cited by 74

Fingolimod for Multiple Sclerosis: Mechanism of Action, Clinical Outcomes, and Future Directions

Mehling, M., Kappos, L., & Derfuss, T. J. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0216-9 · Cited by 74

Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain

Salvemini, D., Doyle, T. M., Kress, M., & Nicol, G. D. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.12.001 · Cited by 71

Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter releasePreprint

Chan, J., Hu, Z., & Sieburth, D. (2012) · Genes & Development · doi:10.1101/gad.188003.112 · Cited by 72

Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway

Zhang, T., Yan, T., Du, J., Wang, S., & Yang, H. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.12.021 · Cited by 72

New developments in C5a receptor signaling

Ward, P. A., & Sarma, J. V. (2012) · Cell Health and Cytoskeleton · doi:10.2147/chc.s27233 · Cited by 71

The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases

Mao‐Draayer, Y., Sarazin, J., Fox, D. A., & Schiopu, E. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.11.008 · Cited by 72

Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes

Kajimoto, T., Mohamed, N. N. I., Badawy, S. M. M., Matovelo, S. A., Hirase, M., Nakamura, S., Yoshida, D., Okada, T., Ijuin, T., & Nakamura, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.808733 · Cited by 74

Lyase to live by: Sphingosine phosphate lyase as a therapeutic target

Kumar, A., & Saba, J. D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903039722 · Cited by 70

The Origin and Maturity of Dendritic Cells Determine the Pattern of Sphingosine 1-Phosphate Receptors Expressed and Required for Efficient Migration

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