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Sphingosine 1-Phosphate Receptor Signaling
Abstract
The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein–coupled receptors to generate multiple downstream signals. These signals modulate homeostasis and pathology on a steep agonist concentration-response curve. Ligand presence is essential for vascular development and endothelial integrity, while acute increases in ligand concentrations result in cardiac death. Understanding this integrated biochemical system has exemplified the impact of both genetics and chemistry. Developing specific tools with defined biochemical properties for the reversible modulation of signals in real time has been essential to complement insights gained from genetic approaches that may be irreversible and compensated. Despite its knife-edge between life and death, this system, based in part on receptor subtype-selectivity and in part on differential attenuation of deleterious signals, now appears to be on the cusp of meaningful therapy for multiple sclerosis.
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“Early studies of primary bile acids have been shown to exert direct negative myocardial chronotropic effects in a dose-dependent fashion132,133.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [132]
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“Though at lower concentrations relative to primary bile acids even in cholestatic states, secondary bile acids can also exert similar effects.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [132]
Citations
Cites
Principles of bioactive lipid signalling: lessons from sphingolipids
Hannun, Y. A., & Obeid, L. M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2329 · Cited by 3,411
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
Sphingosine-1-phosphate: an enigmatic signalling lipid
Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,115
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
MANDALA, S. M., Hajdu, R., Bergstrom, J. D., Quackenbush, E. J., Xie, J., Milligan, J. A., Thornton, R. A., Shei, G.-J., Card, D., Keohane, C.-A., et al. (2002) · Science · doi:10.1126/science.1070238 · Cited by 1,691
Self-citationThe Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E. E., Baumruker, T., HIESTAND, P. C., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200176200 · Cited by 1,512
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Yao, X.-J., Weis, W. I., Stevens, R. C., et al. (2007) · Science · doi:10.1126/science.1150609 · Cited by 1,335
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189
Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C., Hobson, J. P., Rosenfeldt, H. M., Nava, V. E., Chae, S.-S., Lee, M.-J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10905 · Cited by 1,165
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,058
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 904
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
Cyster, J. G. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115628 · Cited by 856
Essential Role for Sphingosine Kinases in Neural and Vascular Development
Mizugishi, K., Yamashita, T., Olivera, A., Miller, G., Spiegel, S., & Proia, R. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11113-11121.2005 · Cited by 764
Structure and function of fatty acid amide hydrolase
McKinney, M. K., & Cravatt, B. F. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133450 · Cited by 680
Sanna, M., Liao, J., Jo, E., Alfonso, C., Ahn, M.-Y., Peterson, M. S., Webb, B., Lefebvre, S., Chun, J. J. M., Gray, N. S., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311743200 · Cited by 627
Self-citationFinding a way out: lymphocyte egress from lymphoid organs
Schwab, S. R., & Cyster, J. G. (2007) · Nature Immunology · doi:10.1038/ni1545 · Cited by 626
Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., & Hoshino, Y. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.5037 · Cited by 597
The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors
Gräler, M. H., & Goetzl, E. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-0910fje · Cited by 544
Protective Effects of Sphingosine 1-Phosphate in Murine Endotoxin-induced Inflammatory Lung Injury
Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D. B., Tuder, R. M., & Garcia, J. G. N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1258oc · Cited by 494
Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Venkataraman, K., Lee, Y.-M., Michaud, J. E., Thangada, S., Ai, Y., Bonkovsky, H. L., Parikh, N. S., Habrukowich, C., & Hla, T. (2008) · Circulation Research · doi:10.1161/circresaha.107.165845 · Cited by 483
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
Allende, M. L., Sasaki, T., Kawai, H., Olivera, A., Mi, Y., van Echten‐Deckert, G., Hajdu, R., Rosenbach, M. J., Keohane, C. A., MANDALA, S. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406512200 · Cited by 463
Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration
Allende, M. L., Dreier, J. L., MANDALA, S. M., & Proia, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314291200 · Cited by 461
Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules
Patel, H. H., Murray, F., & Insel, P. A. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.121506.124841 · Cited by 439
Oo, M. L., Thangada, S., Wu, M.-T., Liu, C. H., Macdonald, T. L., Lynch, K. R., Lin, C., & Hla, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610318200 · Cited by 412
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
Mitra, P., Oskeritzian, C. A., Payne, S. G., Beaven, M. A., Milstien, S., & Spiegel, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603734103 · Cited by 407
Murata, N., Sato, K., Kon, J., Tomura, H., YANAGITA, M., Kuwabara, A., Ui, M., & Okajima, F. (2000) · Biochemical Journal · doi:10.1042/bj3520809 · Cited by 406
Sanna, M. G., Wang, S.-K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E., Cheng, W.-C., et al. (2006) · Nature Chemical Biology · doi:10.1038/nchembio804 · Cited by 406
Self-citationKi16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors
Ohta, H., Sato, K., Murata, N., Damirin, A., Malchinkhuu, E., Kon, J., Kimura, T., Tobo, M., Yamazaki, Y., Watanabe, T., et al. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.4.994 · Cited by 402
Physiological and pathological actions of sphingosine 1-phosphate
Hla, T. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.05.002 · Cited by 391
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
Allende, M. L., Yamashita, T., & Proia, R. L. (2003) · Blood · doi:10.1182/blood-2003-02-0460 · Cited by 388
Sánchez, T., Estrada-Hernandez, T., Paik, J., Wu, M.-T., Venkataraman, K., Brinkmann, V., Claffey, K. P., & Hla, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306896200 · Cited by 377
Jiang, L. I., Collins, J. N. R., Davis, R., Lin, K.-M., DeCamp, D. L., Roach, T. I. A., Hsueh, R. C., Rebres, R. A., Ross, E. M., Taussig, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609695200 · Cited by 363
Forrest, M. J., Sun, S.-Y., Hajdu, R., Bergstrom, J. D., Card, D., Doherty, G., Hale, J. J., Keohane, C. A., Meyers, C., Milligan, J. A., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062828 · Cited by 334
Self-citationJolly, P. S., Bektas, M., Olivera, A., González‐Espinosa, C., Proia, R. L., Rivera, J., Milstien, S., & Spiegel, S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20030680 · Cited by 327
Lo, C. G., Xu, Y., Proia, R. L., & Cyster, J. G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041509 · Cited by 327
Chiba, K. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.05.002 · Cited by 323
Cahalan, M. D., & Parker, I. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090620 · Cited by 303
LaMontagne, K. R., Littlewood-Evans, A. J., Schnell, C., O’Reilly, T., Wyder, L., Sánchez, T., Probst, B., Butler, J., Wood, A. W., Liau, G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2001 · Cited by 302
Autocrine and paracrine roles of sphingosine-1-phosphate
Alvarez, S. E., Milstien, S., & Spiegel, S. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.07.005 · Cited by 293
Lee, M.-J., Thangada, S., Paik, J.-H., Sapkota, G. P., Ancellin, N., Chae, S.-S., Wu, M.-T., Morales‐Ruiz, M., Sessa, W. C., Alessi, D. R., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00324-0 · Cited by 288
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
Niessen, F., Schaffner, F., Furlan-Freguia, C., Pawliński, R., Bhattacharjee, G., Chun, J. J. M., Derian, C. K., Andrade‐Gordon, P., Rosen, H., & Ruf, W. (2008) · Nature · doi:10.1038/nature06663 · Cited by 281
Self-citationSignaling and biological actions of sphingosine 1-phosphate
Hla, T. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00046-x · Cited by 279
Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M., Wang, S., Jo, E., Wong, C., Parker, I., & Cahalan, M. D. (2005) · Nature Immunology · doi:10.1038/ni1269 · Cited by 277
Self-citationSphingosine 1-Phosphate Analogs as Receptor Antagonists
Davis, M. D., Clemens, J. J., Macdonald, T. L., & Lynch, K. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412356200 · Cited by 271
Brinkmann, V., & Lynch, K. R. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00374-6 · Cited by 262
Yanagawa, Y., Sugahara, K., Kataoka, H., Kawaguchi, T., Masubuchi, Y., & Chiba, K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5493 · Cited by 260
Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Saba, J. D., & Hla, T. (2004) · Circulation Research · doi:10.1161/01.res.0000122383.60368.24 · Cited by 260
Ledgerwood, L. G., Lal, G., Zhang, N., Garin, A., Esses, S. J., Ginhoux, F., Mérad, M., Pêche, H., Lira, S. A., Ding, Y., et al. (2007) · Nature Immunology · doi:10.1038/ni1534 · Cited by 251
Scherrer, G., Tóth, P., Filliol, D., Matifas, A., Laustriat, D., Cao, Y. Q., Basbaum, A. I., Dierich, A., Vonesh, J.-L., Gavériaux‐Ruff, C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603359103 · Cited by 250
Brindley, D. N. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20126 · Cited by 244
Jo, E., Sanna, M., Gonzalez‐Cabrera, P. J., Thangada, S., Tigyi, G., Osborne, D. A., Hla, T., Parrill, A. L., & Rosen, H. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.04.019 · Cited by 243
Self-citationLysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing
Lee, H., Goetzl, E. J., & An, S. M. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c612 · Cited by 237
Awad, A. S., Ye, H., Huang, L., Li, L., Foss, F. W., Macdonald, T. L., Lynch, K. R., & Okusa, M. D. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00311.2005 · Cited by 230
Clair, T., Aoki, J., Koh, E., Bandle, R., Nam, S. W., Ptaszynska, M. M., Mills, G. B., Schiffmann, E., Liotta, L. A., & Stracke, M. L. (2003) · PubMed · Cited by 222
Skoura, A., Sánchez, T., Claffey, K. P., MANDALA, S. M., Proia, R. L., & Hla, T. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31123 · Cited by 216
McVerry, B. J., & Garcia, J. G. N. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.08.006 · Cited by 213
Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720
Kharel, Y., Lee, S., Snyder, A. H., Sheasley-O’Neill, S. L., Morris, M. A., Setiady, Y. Y., Zhu, R., Zigler, M. A., Burcin, T. L., Ley, K. F., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506293200 · Cited by 211
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation
Kohno, M., Momoi, M., Oo, M. L., Paik, J., Lee, Y.-M., Venkataraman, K., Ai, Y., Ristimaki, A. P., Fyrst, H., Sano, H., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02341-05 · Cited by 210
Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions
Sigal, Y. J., McDermott, M. I., & Morris, A. J. (2005) · Biochemical Journal · doi:10.1042/bj20041771 · Cited by 207
Endothelial cell barrier regulation by sphingosine 1‐phosphate
McVerry, B. J., & Garcia, J. G. N. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20088 · Cited by 195
Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice
Kono, M., Belyantseva, I. A., Skoura, A., Frolenkov, G. I., Starost, M. F., Dreier, J. L., Lidington, D., Bolz, S., Friedman, T. B., Hla, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700370200 · Cited by 192
Transactivation of Sphingosine 1-Phosphate Receptors Is Essential for Vascular Barrier Regulation
Singleton, P. A., Dudek, S. M., Ma, S.-F., & Garcia, J. G. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603680200 · Cited by 189
Top-Down Lipidomic Screens by Multivariate Analysis of High-Resolution Survey Mass Spectra
Schwudke, D., Hannich, J. T., Surendranath, V., Grimard, V., Moehring, T., Burton, L., Kurzchalia, T. V., & Shevchenko, A. (2007) · Analytical Chemistry · doi:10.1021/ac062455y · Cited by 186
Biological effects of lysophospholipids
Rivera, R., & Chun, J. J. M. (2006) · Springer eBooks · doi:10.1007/112_0507 · Cited by 186
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
Stunff, H. L., Galve‐Roperh, I., Peterson, C. M., Milstien, S., & Spiegel, S. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203123 · Cited by 171
FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation
Brinkmann, V., Pinschewer, D. D., Chiba, K., & Feng, L. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01419-4 · Cited by 164
Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae
Igarashi, J., & Michel, T. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003075200 · Cited by 160
Balatoni, B., Storch, M. K., Swoboda, E., Schönborn, V., Koziel, A., Lambrou, G. N., HIESTAND, P. C., Weissert, R., & Foster, C. A. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.06.023 · Cited by 160
Foss, F. W., Snyder, A. H., Davis, M. D., Rouse, M. D., Okusa, M. D., Lynch, K. R., & Macdonald, T. L. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.10.060 · Cited by 160
Chiba, K., Matsuyuki, H., Maeda, Y., & Sugahara, K. (2006) · PubMed · Cited by 158
Tipping the gatekeeper: S1P regulation of endothelial barrier function
Rosen, H., Sanna, M., Cahalan, S. M., & Gonzalez‐Cabrera, P. J. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.007 · Cited by 155
Self-citationIdentification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate
Parrill, A. L., Wang, D.-A., Bautista, D. L., Brocklyn, J. R. V., Lőrincz, Z., Fischer, D. J., Baker, D. L., Liliom, K., Spiegel, S., & Tigyi, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007680200 · Cited by 155
Sphingosine-1-phosphate receptors and the development of the vascular system
Allende, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00175-0 · Cited by 153
Liu, F., Verin, A. D., Wang, P., Day, R. M., Wersto, R. P., Chrest, F. J., English, D. K., & Garcia, J. G. N. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4323 · Cited by 145
Olivera, A., Urtz, N., Mizugishi, K., Yamashita, Y., Gilfillan, A. M., Furumoto, Y., Gu, H., Proia, R. L., Baumruker, T., & Rivera, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508931200 · Cited by 138
Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system
Takuwa, Y., Okamoto, Y., Yoshioka, K., & Takuwa, N. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.04.003 · Cited by 136
Gonzalez‐Cabrera, P. J., Jo, E., Sanna, M., Brown, S. J., Leaf, N. B., Marsolais, D., Schaeffer, M., Chapman, J. V., Cameron, M. D., Guerrero, M., et al. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.049783 · Cited by 129
Self-citationIntracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells
Zhao, Y., Kalari, S. K., Usatyuk, P. V., Gorshkova, I. A., He, D., Watkins, T., Brindley, D. N., Sun, C., Bittman, R., Garcia, J. G. N., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701279200 · Cited by 128
Kahan, B. D., Karlix, J. L., Ferguson, R. M., Leichtman, A. B., Mulgaonkar, S. P., Gonwa, T. A., Skerjanec, A., Schmouder, R., & Chodoff, L. (2003) · Transplantation · doi:10.1097/01.tp.0000084822.01372.ac · Cited by 127
Waters, C., Sambi, B. S., Kong, K. C., Thompson, D., Pitson, S. M., Pyne, S., & Pyne, N. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208560200 · Cited by 126
Sphingosine 1-phosphate and control of vascular tone
Dantas, A. P., Igarashi, J., & Michel, T. M. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01089.2002 · Cited by 120
Rosen, H., Alfonso, C., Surh, C. D., & McHeyzer‐Williams, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832725100 · Cited by 120
Self-citationHerr, D. R., Grillet, N., Schwander, M., Rivera, R. R., Müller, U., & Chun, J. J. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4245-06.2007 · Cited by 115
The roles of sphingosine-1-phosphate in asthma
Jolly, P. S., Rosenfeldt, H. M., Milstien, S., & Spiegel, S. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00070-6 · Cited by 115
Baudhuin, L. M., Cristina, K. L., Lü, J., & Xu, Y. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.660 · Cited by 108
FTY720 (fingolimod) in renal transplantation
Budde, K., Schütz, M., Glander, P., Peters, H., Waiser, J., Liefeldt, L., Neumayer, H., & Böhler, T. (2006) · Clinical Transplantation · doi:10.1111/j.1399-0012.2006.00596.x · Cited by 100
Takashima, S., Sugimoto, N., Takuwa, N., Okamoto, Y., Yoshioka, K., Takamura, M., Takata, S., Kaneko, S., & Takuwa, Y. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn118 · Cited by 96
Baumruker, T., Billich, A., & Brinkmann, V. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.3.283 · Cited by 94
The role of sphingosine and ceramide kinases in inflammatory responses
Baumruker, T., Bornancin, F., & Billich, A. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.09.001 · Cited by 94
Singer, I. I., Tian, M., Wickham, L. A., Lin, J. J., Matheravidathu, S. S., Forrest, M. J., MANDALA, S. M., & Quackenbush, E. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7151 · Cited by 92
Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors
Pyne, S. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00146-4 · Cited by 88
Don, A. S., Martínez‐Lamenca, C., Webb, W. R., Proia, R. L., Roberts, E., & Rosen, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609124200 · Cited by 88
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Waters, C. M., Connell, M. C., Pyne, S., & Pyne, N. J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.07.011 · Cited by 78
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Self-citationIgarashi, J., Miyoshi, M., Hashimoto, T., Kubota, Y., & Kosaka, H. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707114 · Cited by 64
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Schürer, S. C., Brown, S. J., Gonzalez‐Cabrera, P. J., Schaeffer, M., Chapman, J. V., Jo, E., Chase, P. S., Spicer, T., Hodder, P., & Rosen, H. (2008) · ACS Chemical Biology · doi:10.1021/cb800051m · Cited by 51
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Self-citationFTY720: a new immunosuppressive agent with novel mechanism(s) of action
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Igarashi, J., Miyoshi, M., Hashimoto, T., Kubota, Y., & Kosaka, H. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00117.2006 · Cited by 38
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Self-citationDeng, Q., Clemas, J. A., Chrebet, G. L., Fischer, P. A., Hale, J. J., Li, Z., Mills, S. G., Bergstrom, J. D., MANDALA, S. M., Mosley, R., et al. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029223 · Cited by 36
Yanagawa, Y., Hoshino, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., Sugahara, K., & Chiba, K. (1999) · Transplantation Proceedings · doi:10.1016/s0041-1345(98)01974-5 · Cited by 33
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Insel, P. A., & Patel, H. H. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706981 · Cited by 33
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Vecchiarelli, A., Retini, C., Pietrella, D., Monari, C., & Kozel, T. R. (2000) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(200005)30:5 · Cited by 31
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Long, J. S., Natarajan, V., Tigyi, G., Pyne, S., & Pyne, N. J. (2006) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2006.05.001 · Cited by 30
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Suzuki, S., Kakefuda, T., Amemiya, H., Chiba, K., Hoshino, Y., Kawaguchi, T., Kataoka, H., & Rahman, F. (1998) · Transplant International · doi:10.1007/s001470050111 · Cited by 29
Kahan, B. D. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.01.092 · Cited by 26
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Goetzl, E. J., Wang, W., McGiffert, C., Liao, J., & Huang, M. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00208.x · Cited by 23
Racké, K., Hammermann, R., & Juergens, U. R. (2000) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2000.0241 · Cited by 20
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Im, D., Tomura, H., Tobe, M., Sato, K., & Okajima, F. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fpj04007x · Cited by 10
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Self-citationRutherford, C. L., Ord-Shrimpton, F. U., Sands, W. A., Pediani, J. D., Benovic, J., McGrath, J. C., & Palmer, T. M. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.11.018 · Cited by 7
Off the Shelf but Not Mass Produced
Karliner, J. S. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.06.005 · Cited by 6
Schultz, C. (2006) · Nature Chemical Biology · doi:10.1038/nchembio0806-396 · Cited by 5
Research works printed but not linked: 6
- Clair T, 2003, Cancer Res., 63, 5446
- 10.1042/0264-6021:3520809 · DOI
- Chiba K, 2006, Cell Mol. Immunol., 3, 11
- Suzuki S, 1998, Transplant. Int., 11, 95
- Suzuki S, 1996, Transplant. Proc., 28, 2049
- Merrill AH, 2007, Naunyn-Schmiedebergs Arch. Pharmacol., 374, 321
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Metadata
- Authors
- Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S.
- Affiliations
- Scripps Research Institute (US)
- Departments of Chemical Physiology and Immunology and The Scripps Research Institute Molecular Screening Center, The Scripps Research Institute, La Jolla, California 92037;
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 743-768
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2127032203
- Cited by
- 404
- References
- 151
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 19 · 2020: 17 · 2019: 18 · 2018: 29 · 2017: 27 · 2016: 28 · 2015: 21 · 2014: 27 · 2013: 48 · 2012: 50
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- sphingosine-1-phosphate, S1P receptors, G protein-coupled receptors, receptor signaling, vascular development, endothelial integrity, cardiovascular mortality, signal attenuation, receptor subtype selectivity, multiple sclerosis treatment
- MeSH terms
- Animals, Cardiovascular System, Humans, Lymphoid Tissue, Multiple Sclerosis, Signal Transduction, Receptors, Lysosphingolipid
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