The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Sphingosine 1-Phosphate Receptor Signaling
Abstract
The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein–coupled receptors to generate multiple downstream signals. These signals modulate homeostasis and pathology on a steep agonist concentration-response curve. Ligand presence is essential for vascular development and endothelial integrity, while acute increases in ligand concentrations result in cardiac death. Understanding this integrated biochemical system has exemplified the impact of both genetics and chemistry. Developing specific tools with defined biochemical properties for the reversible modulation of signals in real time has been essential to complement insights gained from genetic approaches that may be irreversible and compensated. Despite its knife-edge between life and death, this system, based in part on receptor subtype-selectivity and in part on differential attenuation of deleterious signals, now appears to be on the cusp of meaningful therapy for multiple sclerosis.
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“Early studies of primary bile acids have been shown to exert direct negative myocardial chronotropic effects in a dose-dependent fashion132,133.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [132]
In the citing paper
“Though at lower concentrations relative to primary bile acids even in cholestatic states, secondary bile acids can also exert similar effects.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [132]
Citations
Cites
Principles of bioactive lipid signalling: lessons from sphingolipids
Hannun, Y. A., & Obeid, L. M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2329 · Cited by 3,411
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H., Kühn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,280
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581
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Spiegel, S., & Milstien, S. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1103 · Cited by 2,115
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Self-citationThe Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
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CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
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Items 401–424 of 424
Conséquences traductionnelles de la perte de 4E-BP1 dans l'adénocarcinome pancréatique
Müller, D. (2016) · theses.fr (ABES) · doi:10.70675/1f894fb2zc2daz446fza7f2z2b28408eb6e2
BindingDB (2013) · UC San Diego · doi:10.7270/q2rf5wch
BindingDB (2021) · UC San Diego · doi:10.7270/q24m984k
BindingDB (2011) · UC San Diego · doi:10.7270/q2h995g4
BindingDB Entry 50048228: A benzo[b]thiophene-based selective type 4 S1P receptor agonist.
BindingDB (2018) · UC San Diego · doi:10.7270/q241702r
BindingDB (2011) · UC San Diego · doi:10.7270/q2t72hr9
BindingDB (2013) · UC San Diego · doi:10.7270/q2222vts
BindingDB Entry 50005762: Modulators of the Sphingosine 1-phosphate receptor 1.
BindingDB (2020) · UC San Diego · doi:10.7270/q2fr00kv
Sphingosine 1-phosphate : regulation of receptor signalling and cross-talk with chemokines
Swan, D. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
INFLAMMATORY INTERACTIONS AND SECRETION IN CARDIAC REMODELING
Yang, F. (2012) · UKnowledge (University of Kentucky)
Metadata
- Authors
- Rosen, H., Gonzalez-Cabrera, P. J., Sanna, M. G., & Brown, S.
- Affiliations
- Scripps Research Institute (US)
- Departments of Chemical Physiology and Immunology and The Scripps Research Institute Molecular Screening Center, The Scripps Research Institute, La Jolla, California 92037;
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 743-768
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2127032203
- Cited by
- 404
- References
- 151
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 19 · 2020: 17 · 2019: 18 · 2018: 29 · 2017: 27 · 2016: 28 · 2015: 21 · 2014: 27 · 2013: 48 · 2012: 50
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Health Sciences › Medicine › Genetics (clinical) › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- sphingosine-1-phosphate, S1P receptors, G protein-coupled receptors, receptor signaling, vascular development, endothelial integrity, cardiovascular mortality, signal attenuation, receptor subtype selectivity, multiple sclerosis treatment
- MeSH terms
- Animals, Cardiovascular System, Humans, Lymphoid Tissue, Multiple Sclerosis, Signal Transduction, Receptors, Lysosphingolipid
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