The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions
Open accessAbstract
The prion (infectious protein) concept has evolved with the discovery of new self-propagating protein states in organisms as diverse as mammals and fungi. The infectious agent of the mammalian transmissible spongiform encephalopathies (TSE) has long been considered the prototypical prion, and recent cell-free propagation and biophysical analyses of TSE infectivity have now firmly established its prion credentials. Other disease-associated protein aggregates, such as some amyloids, can also have prion-like characteristics under certain experimental conditions. However, most amyloids appear to lack the natural transmissibility of TSE prions. One feature that distinguishes the latter from the former is the glycophosphatidylinositol membrane anchor on prion protein, the molecule that is corrupted in TSE diseases. The presence of this anchor profoundly affects TSE pathogenesis, which involves major membrane distortions in the brain, and may be a key reason for the greater neurovirulence of TSE prions relative to many other autocatalytic protein aggregates.
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Cites
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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Prasad, A., Bharathi, V., Sivalingam, V., Girdhar, A., & Patel, B. K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00025 · Cited by 774
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R., & Kayed, R. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-39 · Cited by 633
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
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Metadata
- Authors
- Caughey, B., Baron, G. S., Chesebro, B., & Jeffrey, M.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 78
- Issue
- 1
- Pages
- 177-204
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2138390885
- Cited by
- 323
- References
- 149
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Caughey, B., Baron, G. S., Chesebro, B., & Jeffrey, M. (2009). Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.78.082907.145410
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