The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Fluid Mechanics of Vascular Systems, Diseases, and Thrombosis
Abstract
▪ Abstract The cardiovascular system is an internal flow loop with multiple branches circulating a complex liquid. The hallmarks of blood flow in arteries are pulsatility and branches, which cause wall stresses to be cyclical and nonuniform. Normal arterial flow is laminar, with secondary flows generated at curves and branches. Arteries can adapt to and modify hemodynamic conditions, and unusual hemodynamic conditions may cause an abnormal biological response. Velocity profile skewing can create pockets in which the wall shear stress is low and oscillates in direction. Atherosclerosis tends to localize to these sites and creates a narrowing of the artery lumen—a stenosis. Plaque rupture or endothelial injury can stimulate thrombosis, which can block blood flow to heart or brain tissues, causing a heart attack or stroke. The small lumen and elevated shear rate in a stenosis create conditions that accelerate platelet accumulation and occlusion. The relationship between thrombosis and fluid mechanics is complex, especially in the post-stenotic flow field. New convection models have been developed to predict clinical occlusion from platelet thrombosis in diseased arteries. Future hemodynamic studies should address the complex mechanics of flow-induced, large-scale wall motion and convection of semisolid particles and cells in flowing blood.
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Self-citation
Cited by
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Arterial thrombosis—insidious, unpredictable and deadly
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Jain, A., Barrile, R., van der Meer, A., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M., Louden, C., Hamilton, G., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.742 · Cited by 325
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Metadata
- Authors
- Wootton, D. M., & Ku, D. N.
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 1999-08
- Volume
- 1
- Issue
- 1
- Pages
- 299-329
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2134785906
- Cited by
- 559
- References
- 56
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wootton, D. M., & Ku, D. N. (1999). Fluid Mechanics of Vascular Systems, Diseases, and Thrombosis. Annual Review of Biomedical Engineering. https://doi.org/10.1146/annurev.bioeng.1.1.299
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
