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Cited by 1,016Hydrogels: synthesis, properties, applicationsCollagen: Extraction and CharacterizationPolysaccharides Composition and Applications

The DOI matches its Crossref record; 79 of the 81 references it cites were found in a registry or an index.

Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., Zhang, J.·2000·Annual Review of Biomedical Engineering
DOI 10.1146/annurev.bioeng.2.1.9
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Abstract

▪ Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications.

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Crossref · 10.1146/annurev.bioeng.2.1.9

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79 of 79 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 81 references

Research works printed but not linked: 11

  1. Lowman AM, Peppas NA. 1999. Hydrogels. In Encyclopedia of Controlled Drug Delivery , ed. E Mathiowitz, pp. 397–418. New York: Wiley
  2. Peppas NA, 1986, Hydrogels in Medicine and Pharmacy, Vols. 1, 2.
  3. Andrews AT, 1986, Electrophoresis.
  4. Chaikof EL, 1996, Chemtech, 26, 17
  5. Bell CL, 1995, Adv. Polym. Sci., 122, 126
  6. Okano T, 1998, Biorelated Polymers and Gels.
  7. Tanaka N, 1989, Adv. Chromatogr., 30, 81
  8. Peppas NA. 1996. Hydrogels. In Biomaterials Science , ed. BD Ratner, AS Hoffman, FJ Schoen, JE Lemons, pp. 60–64. San Diego, CA: Academic
  9. Hoffman AS. 1995. Intelligent polymers. In Polymeric Materials Encyclopedia , ed. JC Salamone, pp. 3282–92. Boca Raton, FL: CRC
  10. Tanaka T, 1996, Faraday Discuss., 102, 201
  11. Chen J, 1998, Proc. Int. Symp. Control. Release Bioact. Mater., 25, 60

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Metadata

Authors
Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J.
Affiliations
  • Purdue University West Lafayette (US)
  • Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283;
ORCID
Venue
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Published
2000-08
Volume
2
Issue
1
Pages
9-29
ISSN
  • 1523-9829 (ISSN-L)
  • 1545-4274
DOI
10.1146/annurev.bioeng.2.1.9
OpenAlex
W2157220384
Cited by
1,016
References
81
Citations by year
2026: 17 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 28 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 61 · 2017: 53 · 2016: 57 · 2015: 56 · 2014: 56 · 2013: 65 · 2012: 65
FWCI
1.11
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
hydrogels, biohydrogel, chain conformation, pH-responsive hydrogels, thermosensitive hydrogel, stimuli-responsive hydrogels
MeSH terms
Biomedical Engineering, Chemistry, Physical, Diffusion, Surface Properties, Molecular Structure, Hydrogels, Chemical Phenomena

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