Cited by 1,016Hydrogels: synthesis, properties, applicationsCollagen: Extraction and CharacterizationPolysaccharides Composition and Applications

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Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology

Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., Zhang, J.·2000·Annual Review of Biomedical Engineering

DOI 10.1146/annurev.bioeng.2.1.9

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Abstract

▪ Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications.

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Authors: Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J.
Affiliations: Purdue University West Lafayette (US)
Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283;
ORCID: Peppas, N. A.
Huang, Y.
Ward, J. H.
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2000-08
Volume: 2
Issue: 1
Pages: 9-29
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev.bioeng.2.1.9
OpenAlex: W2157220384
Cited by: 1,016
References: 81
Citations by year: 2026: 17 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 28 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 61 · 2017: 53 · 2016: 57 · 2015: 56 · 2014: 56 · 2013: 65 · 2012: 65
FWCI: 1.11
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords: hydrogels, biohydrogel, chain conformation, pH-responsive hydrogels, thermosensitive hydrogel, stimuli-responsive hydrogels
MeSH terms: Biomedical Engineering, Chemistry, Physical, Diffusion, Surface Properties, Molecular Structure, Hydrogels, Chemical Phenomena

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