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Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology
Abstract
▪ Abstract Hydrogels are cross-linked hydrophilic polymers that can imbibe water or biological fluids. Their biomedical and pharmaceutical applications include a very wide range of systems and processes that utilize several molecular design characteristics. This review discusses the molecular structure, dynamic behavior, and structural modifications of hydrogels as well as the various applications of these biohydrogels. Recent advances in the preparation of three-dimensional structures with exact chain conformations, as well as tethering of functional groups, allow for the preparation of promising new hydrogels. Meanwhile, intelligent biohydrogels with pH- or temperature-sensitivity continue to be important materials in medical applications.
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“Hydrophilic surface modifications, such as the PEG modified surfaces discussed above, have also been widely characterized in the literature and have demonstrated excellent anti-adhesive properties for bacteria cells and proteins.44”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [44]
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Metadata
- Authors
- Peppas, N. A., Huang, Y., Torres-Lugo, M., Ward, J. H., & Zhang, J.
- Affiliations
- Purdue University West Lafayette (US)
- Program on Therapeutic and Diagnostic Devices, Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907-1283;
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2000-08
- Volume
- 2
- Issue
- 1
- Pages
- 9-29
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2157220384
- Cited by
- 1,016
- References
- 81
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 23 · 2023: 26 · 2022: 28 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 61 · 2017: 53 · 2016: 57 · 2015: 56 · 2014: 56 · 2013: 65 · 2012: 65
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- hydrogels, biohydrogel, chain conformation, pH-responsive hydrogels, thermosensitive hydrogel, stimuli-responsive hydrogels
- MeSH terms
- Biomedical Engineering, Chemistry, Physical, Diffusion, Surface Properties, Molecular Structure, Hydrogels, Chemical Phenomena
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