Cited by 341Protein Structure and DynamicsRNA and protein synthesis mechanismsProtein purification and stability

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Protein Folding Theory: From Lattice to All-Atom Models

Mirny, Leonid, Shakhnovich, Eugene·2001·Annual Review of Biophysics and Biomolecular Structure

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Abstract

▪ Abstract This review focuses on recent advances in understanding protein folding kinetics in the context of nucleation theory. We present basic concepts such as nucleation, folding nucleus, and transition state ensemble and then discuss recent advances and challenges in theoretical understanding of several key aspects of protein folding kinetics. We cover recent topology-based approaches as well as evolutionary studies and molecular dynamics approaches to determine protein folding nucleus and analyze other aspects of folding kinetics. Finally, we briefly discuss successful all-atom Monte-Carlo simulations of protein folding and conclude with a brief outlook for the future.

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Authors: Mirny, L., & Shakhnovich, E.
Affiliations: Harvard University (US)
ORCID: Mirny, Leonid
Shakhnovich, Eugene
Venue: Annual Review of Biophysics and Biomolecular Structure
Publisher: Annual Reviews
Published: 2001-06
Volume: 30
Issue: 1
Pages: 361-396
ISSN: 1056-8700 (ISSN-L)
1545-4266
DOI: 10.1146/annurev.biophys.30.1.361
OpenAlex: W2130949317
Cited by: 341
References: 133
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 11 · 2012: 15
FWCI: 2.36
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biophysics and Biomolecular Structure (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein purification and stability
Keywords: protein folding kinetics, nucleation theory, folding nucleus, transition state ensemble, protein evolution, molecular dynamics, lattice model
MeSH terms: Cell Nucleus, Kinetics, Models, Molecular, Monte Carlo Method, Thermodynamics, Protein Folding, Evolution, Molecular

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Protein Folding Theory: From Lattice to All-Atom Models

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