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The State of Lipid Rafts: From Model Membranes to Cells

Edidin, Michael·2003·Annual Review of Biophysics and Biomolecular Structure

Abstract

▪ Abstract Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, detergent solubility to define components of rafts, and sensitivity to cholesterol deprivation to define raft functions implicated sphingolipid- and cholesterol-rich lipid rafts in many cell functions. Despite extensive work, the basis for raft formation in cell membranes and the size of rafts and their stability are all uncertain. Recent work converges on very small rafts <10 nm in diameter that may enlarge and stabilize when their constituents are cross-linked.

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Crossref · 10.1146/annurev.biophys.32.110601.142439

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Metadata

Authors
Edidin, M.
Venue
Annual Review of Biophysics and Biomolecular Structure
Published
2003-06
Volume
32
Issue
1
Pages
257-283
ISSN
  • 1056-8700 (ISSN-L)
  • 1545-4266
OpenAlex
W2122882997
Cited by
1,341
References
6
FWCI
40.75
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The State of Lipid Rafts: From Model Membranes to Cells. https://app.cochat.ai/papers/10.1146/annurev.biophys.32.110601.142439
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Edidin, M. (2003). The State of Lipid Rafts: From Model Membranes to Cells. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.32.110601.142439

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.