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Exosomes: endosomal-derived vesicles shipping extracellular messages

Février, Benoit, Raposo, Graça·2004·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2004.06.003
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Abstract

Exosomes are membrane vesicles released into the extracellular environment upon exocytic fusion of multivesicular endosomes with the cell surface. They have a particular composition reflecting their origin in endosomes as intraluminal vesicles. In vitro and in vivo studies support the contribution of exosomes to an acellular mode of communication, leading to intercellular transfer of molecules. Exosomes may have regulatory functions in the immune system and their application in cancer immunotherapy is promising. The mechanisms involved in exosome secretion and interaction with target cells are as yet unclear. A better understanding of these mechanisms is also essential to determine the link between exosomes and retroviruses.

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Crossref · 10.1016/j.ceb.2004.06.003

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Research works printed but not linked: 55

  1. Harding, 1984, Endocytosis and intracellular processing of transferrin and colloidal-gold transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding, Eur J Cell Biol, 35, 256
  2. Pan, 1985, Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes, J Cell Biol, 101, 942
  3. Sotelo, 1959, An electron microscope study of the rat ovum, J Biophys Biochem Cytol, 5, 327
  4. Futter, 1996, Hopkins: Multivesicular endosomes containing internalized EGF–EGF receptor complexes mature and then fuse directly with lysosomes, J Cell Biol, 132, 1011
  5. Johnstone, 1991, Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins, J Cell Physiol, 147, 27
  6. Zitvogel, 1998, Eradication of established murine tumors using a novel cell-free vaccine: dendritic-cell-derived exosomes, Nat Med, 4, 594
  7. Blanchard, 2002, TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex, J Immunol, 168, 3235
  8. Raposo, 1997, Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation, Mol Biol Cell, 8, 2631
  9. Heijnen, 1999, Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules, Blood, 94, 3791
  10. van Niel, 2001, Intestinal epithelial cells secrete exosome-like vesicles, Gastroenterology, 121, 337
  11. Wolfers, 2001, Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming, Nat Med, 7, 297
  12. Escola, 1998, Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B lymphocytes, J Biol Chem, 273, 20121
  13. Stoorvogel, 2002, The biogenesis and functions of exosomes, Traffic, 3, 321
  14. Wubbolts, 2003, Proteomic and biochemical analyses of human B-cell-derived exosomes. Potential implications for their function and multivesicular body formation, J Biol Chem, 278, 10963
  15. Lamparski, 2002, Production and characterization of clinical grade exosomes derived from dendritic cells, J Immunol Methods, 270, 211
  16. Théry, 1999, Molecular characterization of dendritic-cell-derived exosomes: selective accumulation of the heat shock protein hsc73, J Cell Biol, 147, 599
  17. Thery, 2001, Proteomic analysis of dendritic-cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles, J Immunol, 166, 7309
  18. Van Niel, 2003, Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice, Gut, 52, 1690
  19. Katzmann, 2002, Receptor downregulation and multivesicular-body sorting, Nat Rev Mol Cell Biol, 3, 893
  20. Raiborg, 2003, Protein sorting into multivesicular endosomes, Curr Opin Cell Biol, 15, 446
  21. Katzmann, 2001, Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I, Cell, 106, 145
  22. von Schwedler, 2003, The protein network of HIV budding, Cell, 114, 701
  23. Reggiori, 2001, Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting, EMBO J, 20, 5176
  24. Claas, 2001, Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts, J Biol Chem, 276, 7974
  25. Edidin, 2003, The state of lipid rafts: from model membranes to cells, Annu Rev Biophys Biomol Struct, 32, 257
  26. Mobius, 2003, Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway, Traffic, 4, 222
  27. de Gassart, 2003, Lipid-raft-associated protein sorting in exosomes, Blood, 102, 4336
  28. Rabesandratana, 1998, Decay-accelerating factor (CD55) and membrane inhibitor of reactive lysis (CD59) are released within exosomes during in vitro maturation of reticulocytes, Blood, 91, 2573
  29. Clayton, 2003, Antigen-presenting-cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59, Eur J Immunol, 33, 522
  30. Andre, 2002, Malignant effusions and immunogenic tumour-derived exosomes, Lancet, 360, 295
  31. Admyre, 2003, Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid, Eur Respir J, 22, 578
  32. Denzer, 2000, Follicular dendritic cells carry MHC-class-II-expressing microvesicles at their surface, J Immunol, 165, 1259
  33. Thery, 2002, Indirect activation of naive CD4+ T cells by dendritic-cell-derived exosomes, Nat Immunol, 3, 1156
  34. Hsu, 2003, Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides, J Immunother, 26, 440
  35. Andre, 2004, Exosomes as potent cell-free peptide-based vaccine. I. Dendritic-cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells, J Immunol, 172, 2126
  36. Skokos, 2003, Mast-cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo, J Immunol, 170, 3037
  37. Peche, 2003, Presentation of donor major histocompatibility complex antigens by bone marrow dendritic-cell-derived exosomes modulates allograft rejection, Transplantation, 76, 1503
  38. Riteau, 2003, Exosomes bearing HLA-G are released by melanoma cells, Hum Immunol, 64, 1064
  39. Thery, 2002, Exosomes: composition, biogenesis and function, Nat Rev Immunol, 2, 569
  40. Savina, 2003, Exosome release is regulated by a calcium-dependent mechanism in K562 cells, J Biol Chem, 278, 20083
  41. Martinez, 2000, Synaptotagmin VII regulates Ca2+-dependent exocytosis of lysosomes in fibroblasts, J Cell Biol, 148, 1141
  42. Savina, 2002, The exosome pathway in K562 cells is regulated by Rab11, J Cell Sci, 115, 2505
  43. Tolmachova, 2004, A general role for Rab27a in secretory cells, Mol Biol Cell, 15, 332
  44. Pornillos, 2002, Mechanisms of enveloped RNA virus budding, Trends Cell Biol, 12, 569
  45. Raposo, 2002, Human macrophages accumulate HIV-1 particles in MHC II compartments, Traffic, 3, 718
  46. Pelchen-Matthews, 2003, Infectious HIV-1 assembles in late endosomes in primary macrophages, J Cell Biol, 162, 443
  47. Nguyen, 2003, Evidence that HIV budding in primary macrophages occurs through the exosome release pathway, J Biol Chem, 278, 52347
  48. Gould, 2003, The Trojan exosome hypothesis, Proc Natl Acad Sci USA, 100, 10592
  49. Pelchen-Mathews A, Raposo G, Marsh M: Endosomes, exosomes and Trojan viruses. Trends Microbiol 2004, in press.
  50. Pornillos, 2003, HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein, J Cell Biol, 162, 425
  51. Carlsson, 2003, Characteristics of human prostasomes isolated from three different sources, Prostate, 54, 322
  52. Greco, 2001, Argosomes: a potential vehicle for the spread of morphogens through epithelia, Cell, 106, 633
  53. van Deurs, 1993, Multivesicular bodies in HEp-2 cells are maturating endosomes, Eur J Cell Biol, 61, 208
  54. Hegmans, 2004, Proteomic analysis of exosomes secreted by human mesothelioma cells, Am J Pathol, 164, 1807
  55. Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G: Cells release prions in association with exosomes. Proc Natl Acad Sci USA, in press.

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Metadata

Authors
Février, B., & Raposo, G.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2004-08
Volume
16
Issue
4
Pages
415-421
ISSN
0955-0674
DOI
10.1016/j.ceb.2004.06.003
Cited by
881
References
3
Language
en
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