Modulation of Kv7 channels and excitability in the brain

Greene, Derek L.; Hoshi, Naoto

doi:10.1007/s00018-016-2359-y

Cited by 179Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

Modulation of Kv7 channels and excitability in the brain

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Greene, Derek L., Hoshi, Naoto·2017·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-016-2359-yPMC PMC5243414

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Abstract

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons. We will discuss various factors that have been shown to drastically alter the activity of this channel such as protein and phospholipid interactions, phosphorylation, calcium, and numerous neurotransmitters. Kv7 channels locate to key areas for the control of action potential initiation and propagation. Moreover, we will explore the dynamic surface expression of the channel modulated by neurotransmitters and neural activity. We will also focus on known principle functions of neural Kv7 channels: control of resting membrane potential and spiking threshold, setting the firing frequency, afterhyperpolarization after burst firing, theta resonance, and transient hyperexcitability from neurotransmitter-induced suppression of the M-current. Finally, we will discuss the contribution of altered Kv7 activity to pathologies such as epilepsy and cognitive deficits.

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Muscarinic suppression of the M‐current in the rat sympathetic ganglion is mediated by receptors of the M1‐subtype
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Cholinergic Afferent Stimulation Induces Axonal Function Plasticity in Adult Hippocampal Granule Cells
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KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP 2 ) sensitivity of I Ks to modulate channel activity
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Voltage-dependent effects of opioid peptides on hippocampal CA3 pyramidal neurons in vitro
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Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8
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Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.
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KCNQ5 channels control resting properties and release probability of a synapse
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The Sodium Channel Accessory Subunit Navβ1 Regulates Neuronal Excitability through Modulation of Repolarizing Voltage-Gated K+Channels
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Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5‐bisphosphate‐dependent modulation of Kv7 (M‐type) K+channels
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Coordinated signal integration at the M‐type potassium channel upon muscarinic stimulation
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Properties of single voltage‐dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus
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Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations
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Dynamic PIP 2 interactions with voltage sensor elements contribute to KCNQ2 channel gating
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Activity-Dependent Transcriptional Regulation of M-Type (Kv7) K+ Channels by AKAP79/150-Mediated NFAT Actions
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A recurrent KCNQ2 pore mutation causing early onset epileptic encephalopathy has a moderate effect on M current but alters subcellular localization of Kv7 channels
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Modulation of voltage-gated K + channels by the sodium channel β1 subunit
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Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex
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Protein phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-type potassium channel activity
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Calmodulin Activation Limits the Rate of KCNQ2 K+ Channel Exit from the Endoplasmic Reticulum
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Differential Protein Kinase C-dependent Modulation of Kv7.4 and Kv7.5 Subunits of Vascular Kv7 Channels
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M-Type Potassium Channels Modulate the Intrinsic Excitability of Infralimbic Neurons and Regulate Fear Expression and Extinction
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Ca2+/Calmodulin Disrupts AKAP79/150 Interactions with KCNQ (M-Type) K+Channels
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Increase of the hippocampal theta activity in the Morris water maze reflects learning rather than motor activity
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Characterization of M-Current in Ventral Tegmental Area Dopamine Neurons
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PP2A-Bγ subunit and KCNQ2 K+ channels in bipolar disorder
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G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity
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Cognition enhancement by the acetylcholine releaser DuP 996
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Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells
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A Change in Configuration of the Calmodulin-KCNQ Channel Complex Underlies Ca2+-Dependent Modulation of KCNQ Channel Activity
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Differential effects of Kv7 (M‐) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons
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Dynorphin Selectively Augments the M-Current in Hippocampal CA1 Neurons by an Opiate Receptor Mechanism
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Reduction of an Afterhyperpolarization Current Increases Excitability in Striatal Cholinergic Interneurons in Rat Parkinsonism
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M‐type potassium channels modulate Schaffer collateral–CA1 glutamatergic synaptic transmission
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KCNQ Channels Determine Serotonergic Modulation of Ventral Surface Chemoreceptors and Respiratory Drive
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The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels
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PIP2-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP2 depletion by Gq-coupled receptors in single living neurons
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Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase
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M-current preservation contributes to anticonvulsant effects of valproic acid
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A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression‐burst enhances Kv7/M channel activity
Devaux, J. J., Abidi, A., Roubertie, A., Molinari, F., Becq, H., Lacoste, C., Villard, L., Milh, M., & Aniksztejn, L. (2016) · Epilepsia · doi:10.1111/epi.13366 · Cited by 47 · see citing works
Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed
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Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression
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Channel-anchored Protein Kinase CK2 and Protein Phosphatase 1 Reciprocally Regulate KCNQ2-containing M-channels via Phosphorylation of Calmodulin
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M1-Muscarinic Receptors Promote Fear Memory Consolidation via Phospholipase C and the M-Current
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Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons
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Regulation of Neuronal M-Channel Gating in an Isoform-Specific Manner: Functional Interplay between Calmodulin and Syntaxin 1A
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Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity
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β-Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a β-Subunit-Like Fashion
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Human temporal lobe epilepsy analyses by tissue proteomics
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Gating currents from neuronal KV7.4 Channels: General features and correlation with the ionic conductance
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The Slow Afterhyperpolarization: A Target of β 1 -Adrenergic Signaling in Hippocampus-Dependent Memory Retrieval
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Novel Kv7.1-Phosphatidylinositol 4,5-Bisphosphate Interaction Sites Uncovered by Charge Neutralization Scanning
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Pivoting between Calmodulin Lobes Triggered by Calcium in the Kv7.2/Calmodulin Complex
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Cooperativity between calmodulin-binding sites in Kv7.2 channels
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Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation
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Expression and Functional Roles of Kv7/KCNQ/M-Channels in Rat Medial Entorhinal Cortex Layer II Stellate Cells
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Electrical resonance with voltage-gated ion channels: perspectives from biophysical mechanisms and neural electrophysiology
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ATP Competitive Protein Kinase C Inhibitors Demonstrate Distinct State-Dependent Inhibition
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The Kick-In System: A Novel Rapid Knock-In Strategy
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Action potentials produce a long-term enhancement of M-current in frog sympathetic ganglion
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Activity-dependent downregulation of M-Type (Kv7) K+ channels surface expression requires the activation of iGluRs/Ca2+/PKC signaling pathway in hippocampal neuron
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Axonal Kv7.2/7.3 channels
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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
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Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system
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Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant
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Authors: Greene, D. L., & Hoshi, N.
Affiliations: University of California, Irvine (US)
Corresponding author: Hoshi, Naoto
ORCID: Hoshi, Naoto
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-09-19
Volume: 74
Issue: 3
Pages: 495-508
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-016-2359-y
PMC: PMC5243414
OpenAlex: W2521115404
Cited by: 177
References: 169
Citations by year: 2026: 12 · 2025: 21 · 2024: 16 · 2023: 17 · 2022: 30 · 2021: 22 · 2020: 24 · 2019: 14 · 2018: 11 · 2017: 7 · 2016: 3
FWCI: 1.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS067288)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: Kv7 channels, M-current, neuronal excitability, voltage-gated potassium channels, protein-lipid interactions, phosphorylation, calcium regulation, neurotransmitter modulation, action potential generation, resting membrane potential, afterhyperpolarization, epilepsy, cognitive impairment, brain
MeSH terms: Action Potentials, Animals, Brain, Calcium, Calmodulin, Epilepsy, Humans, Membrane Potentials, Neurons, Signal Transduction, GTP-Binding Protein alpha Subunits, Gq-G11, KCNQ Potassium Channels, Cognitive Dysfunction

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Modulation of Kv7 channels and excitability in the brain

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