Cited by 899Toxic Organic Pollutants ImpactPharmacogenetics and Drug MetabolismGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.

AH RECEPTOR SIGNALING PATHWAYS

Schmidt, Jennifer V., Bradfield, Christopher A.·1996·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.12.1.55

Open this paper in CoChat — free account

Abstract

▪ Abstract The aryl hydrocarbon (Ah) receptor has occupied the attention of toxicologists for over two decades. Interest arose from the early observation that this soluble protein played key roles in the adaptive metabolic response to polycyclic aromatic hydrocarbons and in the toxic mechanism of halogenated dioxins and dibenzofurans. More recent investigations have provided a fairly clear picture of the primary adaptive signaling pathway, from agonist binding to the transcriptional activation of genes involved in the metabolism of xenobiotics. Structure-activity studies have provided an understanding of the pharmacology of this receptor; recombinant DNA approaches have identified the enhancer sequences through which this factor regulates gene expression; and functional analysis of cloned cDNAs has allowed the characterization of the major signaling components in this pathway. Our objective is to review the Ah receptor's role in regulation of xenobiotic metabolism and use this model as a framework for understanding the less well-characterized mechanism of dioxin toxicity. In addition, it is hoped that this information can serve as a model for future efforts to understand an emerging superfamily of related signaling pathways that control biological responses to an array of environmental stimuli.

Integrity signals

Registry

Crossref · 10.1146/annurev.cellbio.12.1.55

Cites

140 of 140 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Poland, A., & Knutson, J. C. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.002505 · Cited by 2,515
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., & Weintraub, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90214-y · Cited by 2,202
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
Murre, C., Page-McCaw, P., Vaessin, H., Caudy, M. A., Jan, L. Y., Jan, Y. N., Cabrera, C. V., Buskin, J. N., Hauschka, S. D., Lassar, A. B., et al. (1989) · Cell · doi:10.1016/0092-8674(89)90434-0 · Cited by 1,815
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
Weintraub, H. M., Davis, R. L., Tapscott, S. J., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D. L., Rupp, R. A. W., Hollenberg, S. M., et al. (1991) · Science · doi:10.1126/science.1846704 · Cited by 1,581

Show all 140 references

Research works printed but not linked: 19

Bacsi SG, 1995, Mol. Pharmacol., 47, 432
Bradfield CA, 1988, Mol. Pharmacol., 34, 229
Brooks B, 1989, Am. J. Hum. Genet., 45, A132
Conney AH, 1956, Cancer Res., 16, 450
Dolwick KM, 1993, Mol. Pharmacol., 44, 911
Eppig JT, 1993, Mouse Genome, 91, 8
Kadesch T, 1993, Cell Growth Diff., 4, 49
Okey AB, 1989, Mol. Pharmacol., 35, 823
Pitot HC, 1980, Cancer Res., 40, 3616
Pohjanvirta R, 1994, Pharmacol. Rev., 46, 483
Poland A, 1975, Mol. Pharmacol., 11, 389
Poland A, 1979, Cancer Res., 39, 3341
Poland A, 1980, Mol. Pharmacol., 17, 86
Poland A, 1990, Mol. Pharmacol., 38, 306
Poland A, 1987, Mol. Pharmacol., 32, 471
Poland A, 1994, Mol. Pharmacol., 46, 915
Pollenz RS, 1994, Mol. Pharmacol., 45, 428
Tucker AN, 1986, Mol. Pharmacol., 29, 372
Vanden Heuvel JP, 1994, Cancer Res., 54, 62

Sorted by citations

Items 301–400 of 899

Constitutively Active Aryl Hydrocarbon Receptor Expressed Specifically in T-Lineage Cells Causes Thymus Involution and Suppresses the Immunization-Induced Increase in Splenocytes1
Nohara, K., Pan, X.-Q., Tsukumo, S., Hida, A., Ito, T., Nagai, H., Inouye, K., Motohashi, H., Yamamoto, M., Fujii-Kuriyama, Y., et al. (2005) · Journal of Immunology · doi:10.4049/jimmunol.174.5.2770 · Cited by 67
The role of endogenous aryl hydrocarbon receptor signaling in cardiovascular physiology
Zhang, N. (2011) · Journal of Cardiovascular Disease Research · doi:10.4103/0975-3583.83033 · Cited by 62
Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells
Dere, E., Lee, A. W., Burgoon, L. D., & Zacharewski, T. R. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-193 · Cited by 62
Aryl hydrocarbon receptor function in early vertebrates:
Hahn, M. E., Woodin, B. R., Stegeman, J. J., & Tillitt, D. E. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)00007-3 · Cited by 62
Vitamin A physiology and its application as a biomarker of contaminant-related toxicity in marine mammals: a review
Simms, W., & Ross, P. S. (2000) · Toxicology and Industrial Health · doi:10.1177/074823370001600706 · Cited by 61
Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes.
Spencer, D. L., Masten, S. A., Lanier, K., Yang, X., Grassman, J. A., Miller, C. R., Sutter, T. R., Lucier, G. W., & Walker, N. J. (1999) · PubMed · Cited by 61
Role of Dioxin Response Element and Nuclear Factor-κB Motifs in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Regulation of Fas and Fas Ligand Expression
Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.028365 · Cited by 60
The aryl hydrocarbon receptor interacts with ATP5α1, a subunit of the ATP synthase complex, and modulates mitochondrial function
Tappenden, D. M., Lynn, S. G., Crawford, R. B., Lee, K., Vengellur, A., Kaminski, N. E., Thomas, R. S., & LaPres, J. J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.05.004 · Cited by 60
Biology and function of the aryl hydrocarbon receptor: report of an international and interdisciplinary conference
Esser, C. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0818-2 · Cited by 62
Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells
Han, Z., Miwa, Y., Obikane, H., Mitsumata, M., Takahashi‐Yanaga, F., Morimoto, S., & Sasaguri, T. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm095 · Cited by 60
Altered Operant Responding for Motor Reinforcement and the Determination of Benchmark Doses Following Perinatal Exposure to Low-Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Markowski, V. P., Zaręba, G., Stern, S., Cox, C., & Weiss, B. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109621 · Cited by 60
Molecular targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) within the zebrafish ovary: Insights into TCDD-induced endocrine disruption and reproductive toxicity
Heiden, T. C. K., Struble, C. A., Rise, M. L., Hessner, M. J., Hutz, R. J., & Carvan, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.07.013 · Cited by 60
AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture
Abbott, B. D., Held, G. A., Wood, C. R., Buckalew, A. R., Brown, J. G., & Schmid, J. R. (1999) · Toxicological Sciences · doi:10.1093/toxsci/47.1.62 · Cited by 60
The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor Activation and Polycyclic Aromatic Hydrocarbon-Induced Pre-B Cell Apoptosis
Quadri, S. A., Qadri, A. N., Hahn, M. E., Mann, K. K., & Sherr, D. H. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12416-9 · Cited by 60
The Aryl Hydrocarbon Receptor Is Involved in UVR-Induced Immunosuppression
Navid, F., Bruhs, A., Schuller, W., Fritsche, E., Krutmann, J., Schwarz, T., & Schwarz, A. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.221 · Cited by 60
In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Accelerated Terminal Differentiation in Fetal Mouse Skin
Loertscher, J. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.2.465 · Cited by 59
Dioxin inhibition of swim bladder development in zebrafish: Is it secondary to heart failure?
Yue, M. S., Peterson, R. E., & Heideman, W. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.02.016 · Cited by 58
2,3,7,8-TCDD Effects on Visual Structure and Function in Swim-Up Rainbow Trout
de Carvalho, P. S. M., & Tillitt, D. E. (2004) · Environmental Science & Technology · doi:10.1021/es034857i · Cited by 58
Insulin Regulation in AhR-null Mice: Embryonic Cardiac Enlargement, Neonatal Macrosomia, and Altered Insulin Regulation and Response in Pregnant and Aging AhR-null Females
Thackaberry, E. A. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg229 · Cited by 58
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
Davis, J. W., Lauer, F. T., Burdick, A. D., Hudson, L. G., & Burchiel, S. W. (2001) · PubMed · Cited by 58
The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Li01 and Resveratrol in Ameliorating Colitis in Mice
Fei, Y., Zhang, S., Han, S., Qiu, B., Lu, Y., Huang, W., Li, F., Chen, D., Berglund, B., Xiao, H., et al. (2022) · Research · doi:10.34133/2022/9863845 · Cited by 57
Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos
Garner, L. V. T., & Giulio, R. T. D. (2012) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2012.01.007 · Cited by 57
Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease
O’Driscoll, C. A., Owens, L. A., Gallo, M. E., Hoffmann, E. J., Afrazi, A., Han, M., Fechner, J. H., Schauer, J. J., Bradfield, C. A., & Mezrich, J. D. (2018) · Particle and Fibre Toxicology · doi:10.1186/s12989-018-0271-3 · Cited by 58
Self-citation
MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylation
Lin, T., Mak, N. K., & Yang, M. S. (2008) · Toxicology · doi:10.1016/j.tox.2008.02.017 · Cited by 58
Aryl Hydrocarbon Receptors in the Frog Xenopus laevis: Two AhR1 Paralogs Exhibit Low Affinity for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
Lavine, J. A., Rowatt, A. J., Klimova, T., Whitington, A. J., Dengler, E., Beck, C., & Powell, W. H. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi228 · Cited by 57
In Uteroand Lactational Exposure of the Male Rat to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Impairs Prostate Development
Roman, B. L., & Peterson, R. E. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8362 · Cited by 57
Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma
Bianchi, A., Bagati, A., Fink, E. E., Affronti, H. C., Lipchick, B. C., Moparthy, S., Long, M. D., Rosario, S. R., Lightman, S. M., Moparthy, K., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci70712 · Cited by 57
Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR)
Oshida, K., Vasani, N. B., Thomas, R. S., Applegate, D. R., Gonzalez, F. J., Aleksunes, L. M., Klaassen, C. D., & Corton, J. C. (2015) · Toxicology · doi:10.1016/j.tox.2015.07.005 · Cited by 56
Analysis of the Aryl Hydrocarbon Receptor (AhR) Signal Transduction Pathway
Denison, M. S., Rogers, J. M., Rushing, S. R., Jones, C. L., Tetangco, S. C., & Heath‐Pagliuso, S. (2002) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0408s11 · Cited by 55
Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs
Chlebowski, A. C., Garcia, G. R., Du, J. K. L., Bisson, W. H., Truong, L., Simonich, S. L. M., & Tanguay, R. L. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx035 · Cited by 55
Transcriptomic analyses uncover emerging roles of mucins, lysosome/secretory addressing and detoxification pathways in insect midguts
Terra, W. R., Dias, R. O., de Oliveira, P. L., Ferreira, C., & Venâncio, T. M. (2018) · Current Opinion in Insect Science · doi:10.1016/j.cois.2018.05.015 · Cited by 56
Comparision of the waterborne and dietary routes of exposure on the effects of Benzo(a)pyrene on biotransformation pathways in Nile tilapia (Oreochromis niloticus)
Costa, J., Ferreira, M., Rey‐Salgueiro, L., & Reis-Henriques, M. A. (2011) · Chemosphere · doi:10.1016/j.chemosphere.2011.04.046 · Cited by 55
Transcriptional response elements in the promoter of CYP6B1, an insect P450 gene regulated by plant chemicals
Petersen, R. A., Niamsup, H., Berenbaum, M. R., & Schuler, M. A. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00486-5 · Cited by 55
Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants
Goshu, E., Jin, H., Fasnacht, R., Sepenski, M., Michaud, J. L., & Fan, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4147-4157.2002 · Cited by 55
The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer
Shadboorestan, A., Koual, M., Dairou, J., & Coumoul, X. (2023) · International Journal of Tryptophan Research · doi:10.1177/11786469231185102 · Cited by 58
Aryl Hydrocarbon Receptor Regulation of Ceramide-induced Apoptosis in Murine Hepatoma 1c1c7 Cells
Reiners, J. J., & Clift, R. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2502 · Cited by 54
A characterization of the ZFL cell line and primary hepatocytes as in vitro liver cell models for the zebrafish (Danio rerio)
Eide, M., Rusten, M., Male, R., Jensen, K. H., & Goksøyr, A. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.11.023 · Cited by 53
Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway
Chen, G., & Bunce, N. J. (2004) · Environmental Toxicology · doi:10.1002/tox.20053 · Cited by 53
Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells
Tanaka, G., Kanaji, S., Hirano, A., Arima, K., Shinagawa, A., Goda, C., Yasunaga, S., Ikizawa, K., Yanagihara, Y., Kubo, M., et al. (2005) · International Immunology · doi:10.1093/intimm/dxh260 · Cited by 55
Comparative Analysis of Temporal and Dose-Dependent TCDD-Elicited Gene Expression in Human, Mouse, and Rat Primary Hepatocytes
Karmaus, A. L., Dere, E., Angrish, M. M., & Zacharewski, T. R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft028 · Cited by 53
Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells
Vázquez-Gómez, G., Rocha‐Zavaleta, L., Rodríguez‐Sosa, M., Petrosyan, P., & Rubio-Lightbourn, J. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.012 · Cited by 55
An update on the dietary ligands of the AhR
Ashida, H., Nishiumi, S., & Fukuda, I. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.11.1429 · Cited by 54
Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver
Galván, N., Jaskula‐Sztul, R., MacWilliams, P. S., Czuprynski, C. J., & Jefcoate, C. R. E. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00338-7 · Cited by 53
Modulation of Th17 development and function by activation of the aryl hydrocarbon receptor – the role of endogenous ligands
Stockinger, B., Veldhoen, M., & Hirota, K. (2009) · European Journal of Immunology · doi:10.1002/eji.200839134 · Cited by 53
Overexpression of latent transforming growth factor-β binding protein 1 (LTBP-1) in dioxin receptor-null mouse embryo fibroblasts
Santiago‐Josefat, B., Mulero‐Navarro, S., Dallas, S. L., & Fernández‐Salguero, P. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.00932 · Cited by 53
Functional Diversity of Vertebrate ARNT Proteins: Identification of ARNT2 as the Predominant Form of ARNT in the Marine Teleost,Fundulus heteroclitus
Powell, W. H., Karchner, S. I., Bright, R., & Hahn, M. E. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0992 · Cited by 52
Cryo-EM structure of the cytosolic AhR complex.
Wen, Z., Zhang, Y., Zhang, B., Hang, Y., Xu, L., Chen, Y., Xie, Q., Zhao, Q., Zhang, L., Li, G., et al. (2023) · Structure · doi:10.1016/j.str.2022.12.013 · Cited by 51
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice
Fritz, W. A., Lin, T.-M., Safe, S. H., Moore, R. W., & Peterson, R. E. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.12.015 · Cited by 52
Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult
Carreira, V., Fan, Y., Kurita, H., Wang, Q., Ko, C., Naticchioni, M., Jiang, M., Koch, S. E., Zhang, X., Biesiada, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142440 · Cited by 55
The aromatic hydrocarbon receptor, transcription, and endocrine aspects of dioxin action
Okino, S. T., & Whitlock, J. P. (2000) · Vitamins and hormones · doi:10.1016/s0083-6729(00)59009-8 · Cited by 52
Rapid Activation of c-Src Kinase by Dioxin Is Mediated by the Cdc37−HSP90 Complex as Part of Ah Receptor Signaling in MCF10A Cells
Park, S., Dong, B., & Matsumura, F. (2006) · Biochemistry · doi:10.1021/bi061925f · Cited by 52
Aryl Hydrocarbon Receptor Modulation of Tumor Necrosis Factor-α-induced Apoptosis and Lysosomal Disruption in a Hepatoma Model That Is Caspase-8-independent
Caruso, J. A., Mathieu, P., Joiakim, A., Zhang, H., & Reiners, J. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508383200 · Cited by 53
Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines
Pande, K., Moran, S. M., & Bradfield, C. A. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.010983 · Cited by 52
Self-citation
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Suppressor of Cytokine Signaling 2 in Murine B Cells
Boverhof, D. R., Tam, E., Harney, A. S., Crawford, R. B., Kaminski, N. E., & Zacharewski, T. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002915 · Cited by 52
Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro.
Wong, J. M. Y., Harper, P. A., Meyer, U., Bock, K. W., Mörike, K., Lagueux, J., Ayotte, P., Tyndale, R. F., Sellers, E. M., Manchester, D., et al. (2001) · Pharmacogenetics · doi:10.1097/00008571-200102000-00010 · Cited by 50
AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-γ1 expression and subsequent adipocyte differentiation
Hanlon, P. R., Ganem, L. G., Cho, Y. C., Yamamoto, M., & Jefcoate, C. R. E. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00083-8 · Cited by 52
Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)- and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells
Yang, S. Y. C., Ahmed, S., Satheesh, S. V., & Matthews, J. B. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2022-x · Cited by 49
Transcription factor aryl hydrocarbon receptor / aryl hydrocarbon receptor nuclear translocator is involved in regulation of the xenobiotic tolerance‐related cytochrome P450 CYP6DA2 in Aphis gossypii Glover
Peng, T., Chen, X., Pan, Y., Zheng, Z., Wei, X., Xi, J., Zhang, J., Gao, X., & Shang, Q. (2017) · Insect Molecular Biology · doi:10.1111/imb.12311 · Cited by 50
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells
Jin, D., Jung, J. W., Lee, Y. S., & Kim, J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.047 · Cited by 51
A Bistable Switch Underlying B-Cell Differentiation and Its Disruption by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Bhattacharya, S., Conolly, R. B., Kaminski, N. E., Thomas, R. S., Andersen, M. E., & Zhang, Q. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq035 · Cited by 50
Alteration in ovarian gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation
Mizuyachi, K., Son, D., Rozman, K. K., & Terranova, P. F. (2002) · Reproductive Toxicology · doi:10.1016/s0890-6238(02)00024-2 · Cited by 51
Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos
Roy, T. S., Andrews, J. E., Seidler, F. J., & Slotkin, T. A. (1998) · Teratology · doi:10.1002/(sici)1096-9926(199808)58:2 · Cited by 123
Arylhydrocarbon receptor expression in the human endometrium
Küchenhoff, A., Seliger, G., Klonisch, T. C., Tscheudschilsuren, G., Kaltwaßer, P., Seliger, E., Buchmann, J., & Fischer, B. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00437-3 · Cited by 51
AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration
Mathew, L. K., Simonich, M. T., & Tanguay, R. L. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.025 · Cited by 50
Transporters for Bile Acids and Organic Anions
Suzuki, H., & Sugiyama, Y. (2002) · Pharmaceutical biotechnology · doi:10.1007/0-306-46812-3_14 · Cited by 50
Lactational Exposure of Han/Wistar Rats to 2,3,7,8-Tetrachlorodibenzo- p -dioxin Interferes with Enamel Maturation and Retards Dentin Mineralization
Gao, Y., Sahlberg, C., Kiukkonen, A., Alaluusua, S., Pohjanvirta, R., Tuomisto, J., & Lukinmaa, P.-L. (2004) · Journal of Dental Research · doi:10.1177/154405910408300211 · Cited by 51
Ah Receptor and ARNT Protein and mRNA Concentrations in Rat Prostate: Effects of Stage of Development and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Treatment
Sommer, R. J., Sojka, K. M., Pollenz, R. S., Cooke, P. S., & Peterson, R. E. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8597 · Cited by 50
Xenobiotics, xenoestrogens and reproduction disturbances in fish
Arukwe, A., & Goksøyr, A. (1998) · Sarsia · doi:10.1080/00364827.1998.10413684 · Cited by 50
Aryl Hydrocarbon Receptor Functions as a Potent Coactivator of E2F1-Dependent Trascription Activity
Watabe, Y., Nazuka, N., Tezuka, M., & Shimba, S. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.389 · Cited by 49
Bone Marrow Stromal Cell Cytochrome P4501B1 Is Required for Pre-B Cell Apoptosis Induced by 7, 12-Dimethylbenz[a]anthracene
Heidel, S. M., Holston, K., Buters, J., Gonzalez, F. J., Jefcoate, C. R. E., & Czupyrynski, C. J. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12398-x · Cited by 49
Arrest of Rat Molar Tooth Development by Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Lukinmaa, P., Sahlberg, C., Leppäniemi, A., Partanen, A., Kovero, O., Pohjanvirta, R., Tuomisto, J., & Alaluusua, S. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9155 · Cited by 49
AhR-Agonist-Induced Transcriptional Changes of Genes Involved in Thyroid Function in Primary Porcine Thyrocytes
Pocar, P., Klonisch, T. C., Brandsch, C., Eder, K., Fröhlich, C., Hoang-Vu, C., & Hombach‐Klonisch, S. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj042 · Cited by 49
Regulation of DNA Binding Activity of the Ligand-Activated Aryl Hydrocarbon Receptor by Tyrosine Phosphorylation
Park, S.-K., Henry, E. C., & Gasiewicz, T. A. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1999 · Cited by 49
Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes
Carreira, V., Fan, Y., Wang, Q., Zhang, X., Kurita, H., Ko, C., Naticchioni, M., Jiang, M., Koch, S. E., Medvedovic, M., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv138 · Cited by 48
Aryl Hydrocarbon Receptor (AhR) Regulates Silica-Induced Inflammation But Not Fibrosis
Beamer, C. A., Seaver, B. P., & Shepherd, D. M. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs024 · Cited by 48
Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function
Geng, S., Mezentsev, A., Kalachikov, S. M., Raith, K., Roop, D. R., & Panteleyev, A. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03282 · Cited by 49
Regulation of the Drosophila distal antennal determinant spineless
Emmons, R. B., Duncan, D. M., & Duncan, I. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.044 · Cited by 48
Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours
Cheung, Y.-L., Kerr, A. C., McFadyen, M. C. E., Melvin, W. T., & Murray, G. I. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00045-2 · Cited by 48
Primary Peripheral T Cells Become Susceptible to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Apoptosis in Vitro upon Activation and in the Presence of Dendritic Cells
Singh, N. P., Nagarkatti, M., & Nagarkatti, P. S. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.043406 · Cited by 48
Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis
Fujita, H., Kosaki, R., Yoshihashi, H., Ogata, T., Tomita, M., Hasegawa, T., Takahashi, T., Matsuo, N., & Kosaki, K. (2002) · Teratology · doi:10.1002/tera.1093 · Cited by 48
A Novel Response to Dioxin
Gao, L., Dong, L., & Whitlock, J. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15358 · Cited by 48
THE JUN N-TERMINAL KINASE INHIBITOR SP600125 IS A LIGAND AND ANTAGONIST OF THE ARYL HYDROCARBON RECEPTOR
Joiakim, A., Mathieu, P., Palermo, C. M., Gasiewicz, T. A., & Reiners, J. J. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.11.1279 · Cited by 48
ARNT2 Is Not Required for TCDD Developmental Toxicity in Zebrafish
Prasch, A. L. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh235 · Cited by 47
Impaired Cardiovascular Function Caused by Different Stressors Elicits a Common Pathological and Transcriptional Response in Zebrafish Embryos
Chen, J. (2013) · Zebrafish · doi:10.1089/zeb.2013.0875 · Cited by 48
Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: Implication for the susceptibility to dioxins
Watanabe, M., Sueoka, K., Sasagawa, I., Nakabayashi, A., Yoshimura, Y., & Ogata, T. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.06.027 · Cited by 47
Aryl Hydrocarbon Receptor Modulates NADPH Oxidase Activity via Direct Transcriptional Regulation of p40phox Expression
Wada, T., Sunaga, H., Ohkawara, R., & Shimba, S. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.083303 · Cited by 47
Nutritional Modulation of the Microbiome and Immune Response
Burr, A. B. P., Bhattacharjee, A., & Hand, T. W. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000419 · Cited by 50
Interference between Progesterone and Dioxin Signal Transduction Pathways
Kuil, C. W., Brouwer, A., van der Saag, P. T., & van der Burg, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8829 · Cited by 47
Depletion of Arylhydrocarbon Receptor during Adipose Differentiation in 3T3-L1 Cells
Shimba, S., Todoroki, K., Aoyagi, T., & Tezuka, M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9100 · Cited by 45
Unique Property of Some Synthetic Retinoids: Activation of the Aryl Hydrocarbon Receptor Pathway
Gambone, C. J., Hutcheson, J. M., Gabriel, J. L., Beard, R. L., Chandraratna, R. A. S., Soprano, K. J., & Soprano, D. R. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12866-0 · Cited by 47
REDOX REGULATION OF c-Ha-ras AND OSTEOPONTIN SIGNALING IN VASCULAR SMOOTH MUSCLE CELLS: Implications in Chemical Atherogenesis
Ramos, K. S. (1999) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.243 · Cited by 47
A study on diurnal mRNA expression of CYP1A1, AHR, ARNT, and PER2 in rat pituitary and liver
Huang, P., Ceccatelli, S., & Rannug, A. (2002) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(01)00111-9 · Cited by 46
Reassessing the evidence for the link between dioxin and endometriosis: from molecular biology to clinical epidemiology
Guo, S., Simsa, P., Kyama, C. M., Mihalyi, A., Fulop, V., Othman, E.-E. R., & D’Hooghe, T. M. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap075 · Cited by 45
Effects of TCDD on the Fate of Naive Dendritic Cells
Bankoti, J., Burnett, A., Navarro, S., Miller, A. K., Rase, B., & Shepherd, D. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq063 · Cited by 46
Modulation of AhR-Mediated CYP1A1 mRNA and EROD Activities by 17 -Estradiol and Dexamethasone in TCDD-Induced H411E Cells
Lai, K. P. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfh045 · Cited by 46
Transforming Growth Factor-β3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Thomae, T. L., Stevens, E. A., & Bradfield, C. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410780200 · Cited by 46
Self-citation
Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
Kolluri, S. K., Balduf, C., Hofmann‐Apitius, M., & Göttlicher, M. (2001) · PubMed · Cited by 46
Ligand Binding and Functional Selectivity of l-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR)
Nuti, R., Gargaro, M., Matino, D., Dolciami, D., Grohmann, U., Puccetti, P., Fallarino, F., & Macchiarulo, A. (2014) · Journal of Chemical Information and Modeling · doi:10.1021/ci5005459 · Cited by 45
The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer
Safe, S. H., & Zhang, L. (2022) · Cancers · doi:10.3390/cancers14225574 · Cited by 45
2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Differentiation of Alloreactive CD8+T Cells Toward a Regulatory T Cell Phenotype by a Mechanism that is Dependent on Aryl Hydrocarbon Receptor in CD4+T Cells
Funatake, C. J., Marshall, N. B., & Kerkvliet, N. I. (2008) · Journal of Immunotoxicology · doi:10.1080/15476910802019037 · Cited by 48

Authors: Schmidt, J. V., & Bradfield, C. A.
Affiliations: Northwestern University (US)
University of Wisconsin–Madison (US)
ORCID: Schmidt, Jennifer V.
Bradfield, Christopher A.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1996-11
Volume: 12
Issue: 1
Pages: 55-89
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.12.1.55
OpenAlex: W2133972226
Cited by: 899
References: 140
Citations by year: 2026: 3 · 2025: 9 · 2024: 3 · 2023: 16 · 2022: 10 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 28 · 2017: 29 · 2016: 16 · 2015: 19 · 2014: 28 · 2013: 27 · 2012: 26
FWCI: 11.14
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA09560, T32CA009560)
National Institute of Environmental Health Sciences (ES06883, R01ES006883)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: aryl hydrocarbon receptor, dioxin toxicity, dibenzofuran, polycyclic aromatic hydrocarbons, xenobiotic metabolism, transcriptional activation, gene expression regulation, enhancers, structure-activity relationship, signaling pathways, ecotoxicology
MeSH terms: Amino Acid Sequence, Animals, Binding Sites, Dioxins, Humans, Molecular Sequence Data, Peptide Mapping, Signal Transduction, Receptors, Aryl Hydrocarbon, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

AH RECEPTOR SIGNALING PATHWAYS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks