Cited by 839Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerPlanarian Biology and Electrostimulation

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FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

Harland, Richard, Gerhart, John·1997·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.13.1.611

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Abstract

▪ Abstract The organizer is formed in an equatorial sector of the blastula stage amphibian embryo by cells that have responded to two maternal agents: a general meso-endoderm inducer (involving the TFG-β signaling pathway) and a dorsal modifier (probably involving the Wnt signaling pathway). The meso-endoderm inducer is secreted by most vegetal cells, those containing maternal materials that had been localized in the vegetal hemisphere of the oocyte during oogenesis. As a consequence of the inducer's distribution and action, the competence domains of prospective ectoderm, mesoderm, and endoderm are established in an animal-to-vegetal order in the blastula. The dorsal modifier signal is secreted by a sector of cells of the animal and vegetal hemispheres on one side of the blastula. These cells contain maternal materials transported there in the first cell cycle from the vegetal pole of the egg along microtubules aligned by cortical rotation. The Nieuwkoop center is the region of blastula cells secreting both maternal signals, and hence specifying the organizer in an equatorial sector. Final steps of organizer formation at the late blastula or early gastrula stage may involve locally secreted zygotic signals as well. At the gastrula stage, the organizer secretes a variety of zygotic proteins that act as antagonists to various members of the BMP and Wnt families of ligands, which are secreted by cells of the competence domains surrounding the organizer. BMPs and Wnts favor ventral development, and cells near the organizer are protected from these agents by the organizer's inducers. The nearby cells are derepressed in their inherent capacity for dorsal development, which is apparent in the neural induction of the ectoderm, dorsalization of the mesoderm, and anteriorization of the endoderm. The organizer also engages in extensive specialized morphogenesis, which brings it within range of responsive cell groups. It also self-differentiates to a variety of axial tissues of the body.

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Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4
Zimmerman, L. B., Jesús-Escobar, J. M. D., & Harland, R. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80133-6 · Cited by 1,639
Self-citation
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,184
Self-citation
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint
Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167
Embryonic Development and Induction
(1939) · Annals of the Entomological Society of America · doi:10.1093/aesa/32.3.657 · Cited by 1,148
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4
Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos
Amaya, E., Musci, T. J., & Kirschner, M. W. (1991) · Cell · doi:10.1016/0092-8674(91)90616-7 · Cited by 1,085
Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction
Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D., & Herrmann, B. G. (1991) · Cell · doi:10.1016/0092-8674(91)90573-h · Cited by 971
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors
Slack, J. M. W., Darlington, B. G., Heath, J. K., & Godsave, S. F. (1987) · Nature · doi:10.1038/326197a0 · Cited by 934
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
Lagna, G., Hata, A., Hemmati‐Brivanlou, A., & Massagué, J. (1996) · Nature · doi:10.1038/383832a0 · Cited by 905
Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo
Kimelman, D., & Kirschner, M. W. (1987) · Cell · doi:10.1016/0092-8674(87)90110-3 · Cited by 872
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
Eppert, K., Scherer, S. W., Özçelik, H., Pirone, R., Hoodless, P. A., Kim, H., Tsui, L.-C., Bapat, B. V., Gallinger, S., Andrulis, I. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80128-2 · Cited by 845
TGFβ Signaling: Receptors, Transducers, and Mad Proteins
Massagué, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81296-9 · Cited by 836
Induction of epidermis and inhibition of neural fate by Bmp-4
Wilson, P. A., & Hemmati-Brivanlou, A. (1995) · Nature · doi:10.1038/376331a0 · Cited by 787
Neural Induction by the Secreted Polypeptide Noggin
Lamb, T. M., Knecht, A. K., Smith, W. C., Stachel, S. E., Economides, A. N., Stahl, N., Yancopolous, G. D., & Harland, R. M. (1993) · Science · doi:10.1126/science.8235591 · Cited by 785
Self-citation
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation
Kroll, K. L., & Amaya, E. (1996) · Development · doi:10.1242/dev.122.10.3173 · Cited by 781
A common plan for dorsoventral patterning in Bilateria
De Robertis, E. M., & Sasai, Y. (1996) · Nature · doi:10.1038/380037a0 · Cited by 780
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity
Hemmati‐Brivanlou, A., Kelly, O., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90320-4 · Cited by 761
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759
Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer
Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
Sasai, Y., Lu, B., Steinbeißer, H., & Robertis, E. M. D. (1995) · Nature · doi:10.1038/376333a0 · Cited by 713
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
Hoodless, P. A., Haerry, T. E., Abdollah, S., Stapleton, M., O’Connor, M. B., Attisano, L., & Wrana, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81250-7 · Cited by 698
Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos
Heasman, J., Crawford, A., Goldstone, K., Garner-Hamrick, P., Gumbiner, B., McCrea, P., Kintner, C., Noro, C., & Wylie, C. (1994) · Cell · doi:10.1016/0092-8674(94)90069-8 · Cited by 693
A transcriptional partner for MAD proteins in TGF-β signalling
Chen, X., Rubock, M. J., & Whitman, M. (1996) · Nature · doi:10.1038/383691a0 · Cited by 684
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
Chitnis, A. B., Henrique, D., Lewis, J. H., Ish‐Horowicz, D., & Kintner, C. R. (1995) · Nature · doi:10.1038/375761a0 · Cited by 675
A human Mad protein acting as a BMP-regulated transcriptional activator
Liu, F., Hata, A., Baker, J. C., Doody, J. F., Cárcamo, J. M., Harland, R. M., & Massagué, J. (1996) · Nature · doi:10.1038/381620a0 · Cited by 673
Self-citation
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
Smith, J. C., Price, B. M. J., Nimmen, K. V., & Huylebroeck, D. (1990) · Nature · doi:10.1038/345729a0 · Cited by 656
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center
Smith, W. C., & Harland, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90070-f · Cited by 649
Self-citation
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
Thomsen, G. H., Woolf, T. M., Whitman, M., Sokol, S. Y., Vaughan, J. M., Vale, W., & Melton, D. A. (1990) · Cell · doi:10.1016/0092-8674(90)90445-k · Cited by 586
Multiple defects and perinatal death in mice deficient in follistatin
Matzuk, M. M., Lu, N., Vogel, H. S., Sellheyer, K., Roop, D. R., & Bradley, A. (1995) · Nature · doi:10.1038/374360a0 · Cited by 584
Vital dye mapping of the gastrula and neurula of Xenopus laevis
Keller, R. E. (1976) · Developmental Biology · doi:10.1016/0012-1606(76)90127-5 · Cited by 576
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development
Dale, L., Howes, G., Price, B. M. J., et al. (1992) · Development · doi:10.1242/dev.115.2.573 · Cited by 574
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos
Hemmati‐Brivanlou, A., & Melton, D. (1992) · Nature · doi:10.1038/359609a0 · Cited by 559
Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
Thomas, P. Q., & Beddington, R. S. P. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00753-1 · Cited by 553
Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling.
Funayama, N., Fagotto, F., McCrea, P. D., & Gumbiner, B. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.5.959 · Cited by 545
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 1×
“though they block the axis-inducing activity of injected wnt mRNA (Hoppler et al 1996, Sokol 1996, Leyns et al 1997, Wang et al 1997); whereas overexpression of GSK3 and depletion of β-catenin does block axis formation.”
Background
Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis
Lemaire, P., Garrett, N., & Gurdon, J. B. (1995) · Cell · doi:10.1016/0092-8674(95)90373-9 · Cited by 518
β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos
Schneider, S., Steinbeißer, H., Warga, R. M., & Hausen, P. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00546-1 · Cited by 515
Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
Halpern, M. E., Ho, R. K., Walker, C., & Kimmel, C. B. (1993) · Cell · doi:10.1016/s0092-8674(05)80087-x · Cited by 508
Fate map for the 32-cell stage ofXenopus laevis
Dale, L., & Slack, J. M. W. (1987) · Development · doi:10.1242/dev.99.4.527 · Cited by 507
Injected Wnt RNA induces a complete body axis in Xenopus embryos
Sokol, S. Y., Christian, J. L., Moon, R. T., & Melton, D. A. (1991) · Cell · doi:10.1016/0092-8674(91)90069-b · Cited by 501
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C., & Miyazono, K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.1.217 · Cited by 496
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
He, X., Saint‐Jeannet, J., Woodgett, J. R., VARMUS, H. E., & Dawid, I. B. (1995) · Nature · doi:10.1038/374617a0 · Cited by 484
Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
Green, J. B. A., New, H. V., & Smith, J. C. (1992) · Cell · doi:10.1016/0092-8674(92)90550-v · Cited by 482
DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction
Jones, C. M., Lyons, K. M., An, P., et al. (1992) · Development · doi:10.1242/dev.115.2.639 · Cited by 481
The formation of the mesoderm in urodelean amphibians
Nieuwkoop, P. D. (1969) · Development Genes and Evolution · doi:10.1007/bf00578701 · Cited by 475
A frizzled homolog functions in a vertebrate Wnt signaling pathway
Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C.-J., & Moon, R. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70716-1 · Cited by 469
A homeobox gene essential for zebrafish notochord development
Talbot, W. S., Trevarrow, B., Halpern, M. E., Melby, A. E., Farr, G., Postlethwait, J. H., Jowett, T., Kimmel, C. B., & Kimelman, D. (1995) · Nature · doi:10.1038/378150a0 · Cited by 465
Ectodermal Patterning in Vertebrate Embryos
Sasai, Y., & Robertis, E. M. D. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8445 · Cited by 465
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.Preprint
Christian, J. L., & Moon, R. T. (1993) · Genes & Development · doi:10.1101/gad.7.1.13 · Cited by 453
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo
Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90409-x · Cited by 451
Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors
Rosa, F., Roberts, A. B., Danielpour, D., Dart, L. L., Sporn, M. B., & Dawid, I. B. (1988) · Science · doi:10.1126/science.3422517 · Cited by 449
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
Suzuki, A., Thies, R. S., Yamaji, N., Song, J. J., Wozney, J. M., Murakami, K., & Ueno, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10255 · Cited by 448
Vital dye mapping of the gastrula and neurula of Xenopus laevis
Keller, R. E. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90331-0 · Cited by 438
Origins of the avian neural crest: the role of neural plate-epidermal interactions
Selleck, M. A. J., & Bronner-Fraser, M. E. (1995) · Development · doi:10.1242/dev.121.2.525 · Cited by 438
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
Graff, J. M., Bansal, A., & Melton, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81249-0 · Cited by 424
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
Pourquié, O., Fan, C., Coltey, M., Hirsinger, E., 渡邉, 裕., Bréant, C., Francis‐West, P. H., Brickell, P. M., Tessier‐Lavigne, M., & Douarin, N. M. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81291-x · Cited by 422
Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development
Gerhart, J. C., Danilchik, M. V., Doniach, T., Roberts, S., Rowning, B. A., & Stewart, R. (1989) · Development · doi:10.1242/dev.107.supplement.37 · Cited by 420
Self-citation
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
Jones, C. M., Kuehn, M. R., Hogan, B. L. M., Smith, J. C., & Wright, C. V. E. (1995) · Development · doi:10.1242/dev.121.11.3651 · Cited by 419
Processed Vg1 protein is an axial mesoderm inducer in xenopus
Thomsen, G. H., & Melton, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)80045-g · Cited by 416
Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway
Larabell, C. A., Torres, M. A., Rowning, B. A., Yost, C., Miller, J. R., Wu, M., Kimelman, D., & Moon, R. T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1123 · Cited by 407
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406
On the function of BMP‐4 in patterning the marginal zone of the Xenopus embryo.
Fainsod, A., Steinbeißer, H., & Robertis, E. M. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06830.x · Cited by 397
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern
Lamb, T. M., & Harland, R. M. (1995) · Development · doi:10.1242/dev.121.11.3627 · Cited by 385
Self-citation
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
Varlet, I., Collignon, J., & Robertson, E. J. (1997) · Development · doi:10.1242/dev.124.5.1033 · Cited by 383
MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.
Hopwood, N., Plück, A., & Gurdon, J. B. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08505.x · Cited by 379
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderminducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis
Christian, J. L., McMahon, J. A., McMahon, A. P., & Moon, R. T. (1991) · Development · doi:10.1242/dev.111.4.1045 · Cited by 374
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.Preprint
Taira, M., Jamrich, M., Good, P. J., & Dawid, I. B. (1992) · Genes & Development · doi:10.1101/gad.6.3.356 · Cited by 371
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.Preprint
Hawley, S. H. B., Wünnenberg-Stapleton, K., Hashimoto, C., Laurent, M. N., Watabe, T., Blumberg, B., & Cho, K. W. (1995) · Genes & Development · doi:10.1101/gad.9.23.2923 · Cited by 368
Regional expression, pattern and timing of convergence and extension during gastrulation ofXenopus laevis
Keller, R. E., & Danilchik, M. (1988) · Development · doi:10.1242/dev.103.1.193 · Cited by 367
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
Smith, W. C., Knecht, A. K., Wu, M., & Harland, R. M. (1993) · Nature · doi:10.1038/361547a0 · Cited by 361
Self-citation
The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer
Kimelman, D., Abraham, J. A., Haaparanta, T., Palisi, T. M., & Kirschner, M. W. (1988) · Science · doi:10.1126/science.3194757 · Cited by 360
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor)
Asashima, M., Nakano, H., Shimada, K., Kinoshita, K., Ishii, K., Shibai, H., & Ueno, N. (1990) · Development Genes and Evolution · doi:10.1007/bf00383771 · Cited by 358
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Preprint
Hoppler, S., Brown, J. D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2805 · Cited by 346
Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4
Hemmati‐Brivanlou, A., & Thomsen, G. H. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170109 · Cited by 345
eFGF regulates Xbra expression during Xenopus gastrulation.
Isaacs, H. V., Pownall, M. E., & Slack, J. M. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06769.x · Cited by 340
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.Preprint
Baker, J. C., & Harland, R. M. (1996) · Genes & Development · doi:10.1101/gad.10.15.1880 · Cited by 340
Self-citation
Cell motility driving mediolateral intercalation in explants of Xenopus laevis
Shih, J., & Keller, R. E. (1992) · Development · doi:10.1242/dev.116.4.901 · Cited by 333
Antagonizing the Spemann organizer: role of the homeobox gene Xvent‐1.
Gawantka, V., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00317.x · Cited by 330
Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis
Altaba, A. R. I., & Jessell, T. M. (1992) · Development · doi:10.1242/dev.116.1.81 · Cited by 329
Activin signalling and response to a morphogen gradient
Gurdon, J. B., Harger, P. L., Mitchell, A., & Lemaire, P. (1994) · Nature · doi:10.1038/371487a0 · Cited by 329
A nodal-related gene defines a physical and functional domain within the Spemann organizer
Smith, W. C., McKendry, R., Ribisi, S., & Harland, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90050-0 · Cited by 329
Self-citation
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development
Tang, T. L., Freeman, R. M., O’Reilly, A. M., Neel, B. G., & Sokol, S. Y. (1995) · Cell · doi:10.1016/0092-8674(95)90498-0 · Cited by 324
FGF signalling in the early specification of mesoderm in Xenopus
Amaya, E., Stein, P. A., Musci, T. J., & Kirschner, M. W. (1993) · Development · doi:10.1242/dev.118.2.477 · Cited by 322
Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle
Blitz, I. L., & Cho, W. Y. (1995) · Development · doi:10.1242/dev.121.4.993 · Cited by 314
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.
Dominguez, I. M., Itoh, K., & Sokol, S. Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8498 · Cited by 314
Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning
Zhang, J., & King, M. L. (1996) · Development · doi:10.1242/dev.122.12.4119 · Cited by 311
Xwnt-11: a maternally expressed Xenopus wnt gene
Ku, M., & Melton, D. A. (1993) · Development · doi:10.1242/dev.119.4.1161 · Cited by 304
Progressive determination during formation of the anteroposterior axis in Xenopus laevis
Sive, H. L., Hattori, K., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90413-3 · Cited by 296
Caudalization of neural fate by tissue recombination and bFGF
Cox, W. G., & Hemmati‐Brivanlou, A. (1995) · Development · doi:10.1242/dev.121.12.4349 · Cited by 293
Regional specification within the mesoderm of early embryos ofXenopus laevis
Dale, L., & Slack, J. M. W. (1987) · Development · doi:10.1242/dev.100.2.279 · Cited by 290
Early cellular interactions promote embryonic axis formation in Xenopus laevis
Gimlich, R. L., & Gerhart, J. C. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90042-3 · Cited by 289
Self-citation
Expression of a novel FGF in theXenopusembryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification
Isaacs, H. V., Tannahill, D., & Slack, J. M. W. (1992) · Development · doi:10.1242/dev.114.3.711 · Cited by 289
Cephalic expression and molecular characterization of Xenopus En-2
Hemmati‐Brivanlou, A., de la Torre, J. R., Holt, C. E., & Harland, R. M. (1991) · Development · doi:10.1242/dev.111.3.715 · Cited by 288
Self-citation
Vertebrate Embryonic Induction: Mesodermal and Neural Patterning
Kessler, D. S., & Melton, D. A. (1994) · Science · doi:10.1126/science.7939714 · Cited by 281
eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus
Pownall, M. E., Tucker, A. S., Slack, J. M. W., & Isaacs, H. V. (1996) · Development · doi:10.1242/dev.122.12.3881 · Cited by 280
Mesoderm formation in response to Brachyury requires FGF signalling
Schulte‐Merker, S., & Smith, J. C. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00017-0 · Cited by 276
Dorsalization and neural induction: properties of the organizer inXenopus laevis
Smith, J. C., & Slack, J. M. W. (1983) · Development · doi:10.1242/dev.78.1.299 · Cited by 271
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesoderm
Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., & Niehrs, C. (1996) · Development · doi:10.1242/dev.122.10.3045 · Cited by 270
Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication
Wilson, P. A., & Melton, D. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00152-4 · Cited by 264
Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer
Aono, A., Hazama, M., Notoya, K., Taketomi, S., Yamasaki, H., Tsukuda, R., Sasaki, S., & Fujisawa, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1712 · Cited by 258
A transient array of parallel microtubules in frog eggs: Potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis
Elinson, R. P., & Rowning, B. A. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90281-3 · Cited by 252
The formation of the mesoderm in urodelean amphibians
Boterenbrood, E. C., & Nieuwkoop, P. D. (1973) · Development Genes and Evolution · doi:10.1007/bf00575837 · Cited by 248
Endoderm induction by the organizer‐secreted factors chordin and noggin in Xenopus animal caps.
Sasai, Y., Lu, B., Piccolo, S., & Robertis, E. M. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00832.x · Cited by 245
Mesoderm movement and fate during avian gastrulation and neurulation
Schoenwolf, G. C., García‐Martínez, V., & Dias, M. S. (1992) · Developmental Dynamics · doi:10.1002/aja.1001930304 · Cited by 239
The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor
Holley, S. A., Neul, J. L., Attisano, L., Wrana, J. L., Sasai, Y., O’Connor, M. B., Robertis, E. M. D., & Ferguson, E. L. (1996) · Cell · doi:10.1016/s0092-8674(00)80134-8 · Cited by 239
Activation of muscle-specific actin genes in xenopus development by an induction between animal and vegetal cells of a blastula
Gurdon, J. B., Fairman, S., Mohun, T. J., & Brennan, S. M. (1985) · Cell · doi:10.1016/s0092-8674(85)80072-6 · Cited by 238
An inductive role for the endoderm in Xenopus cardiogenesis
Nascone, N., & Mercola, M. A. (1995) · Development · doi:10.1242/dev.121.2.515 · Cited by 234
Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer
Grunz, H., & Tacke, L. (1989) · Cell Differentiation and Development · doi:10.1016/0922-3371(89)90006-3 · Cited by 233
The heritage of experimental embryology: Hans Spemann and the organizer
Slack, J. (1988) · Choice Reviews Online · doi:10.5860/choice.26-0295 · Cited by 233
Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene.Preprint
von Dassow, G., Schmidt, J. E., & Kimelman, D. (1993) · Genes & Development · doi:10.1101/gad.7.3.355 · Cited by 232
Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage
Shih, J., & Fraser, S. E. (1996) · Development · doi:10.1242/dev.122.4.1313 · Cited by 231
A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.Preprint
Dirksen, M., & Jamrich, M. (1992) · Genes & Development · doi:10.1101/gad.6.4.599 · Cited by 228
Axis determination in eggs of Xenopus laevis: A critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation
Scharf, S. R., & Gerhart, J. C. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90255-5 · Cited by 228
Self-citation
Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
Ferguson, E. L., & Anderson, K. V. (1992) · Development · doi:10.1242/dev.114.3.583 · Cited by 228
Mesoderm induction by activin requires FGF-mediated intracellular signals
LaBonne, C., & Whitman, M. (1994) · Development · doi:10.1242/dev.120.2.463 · Cited by 228
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3
Pierce, S. B., & Kimelman, D. (1995) · Development · doi:10.1242/dev.121.3.755 · Cited by 227
Inducing factors in Xenopus early embryos
Slack, J. M. W. (1994) · Current Biology · doi:10.1016/s0960-9822(94)00027-8 · Cited by 226
Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin
McGrew, L. L., Lai, C.-J., & Moon, R. T. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0027 · Cited by 224
Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.Preprint
Watabe, T., Kim, S., Candia, A. F., Rothbächer, U., Hashimoto, C., Inoue, K., & Cho, K. W. (1995) · Genes & Development · doi:10.1101/gad.9.24.3038 · Cited by 224
Mesoderm induction in Xenopus caused by activation of MAP kinase
Umbhauer, M., Marshall, C. J., Mason, C., Old, R. W., & Smith, J. C. (1995) · Nature · doi:10.1038/376058a0 · Cited by 221
Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals
Papalopulu, N., & Kintner, C. R. (1993) · Development · doi:10.1242/dev.117.3.961 · Cited by 219
The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF
Green, J. B. A., Howes, G., Symes, K., et al. (1990) · Development · doi:10.1242/dev.108.1.173 · Cited by 217
The causal analysis of development in the past half century: a personal history
Waelsch, S. G. (1992) · Development · doi:10.1242/dev.116.supplement.1 · Cited by 217
The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm
Carnac, G., Kodjabachian, L., Gurdon, J. B., & Lemaire, P. (1996) · Development · doi:10.1242/dev.122.10.3055 · Cited by 212
bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus
Kengaku, M., & Okamoto, H. (1995) · Development · doi:10.1242/dev.121.9.3121 · Cited by 210
Activin-mediated mesoderm induction requires FGF
Cornell, R. A., & Kimelman, D. (1994) · Development · doi:10.1242/dev.120.2.453 · Cited by 210
Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm
Knecht, A. K., Good, P. J., Dawid, I. B., & Harland, R. M. (1995) · Development · doi:10.1242/dev.121.6.1927 · Cited by 208
Self-citation
Involvement of p21ras in Xenopus mesoderm induction
Whitman, M., & Melton, D. A. (1992) · Nature · doi:10.1038/357252a0 · Cited by 206
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
Ekker, S. C., McGrew, L. L., Lai, C.-J., Lee, J. J., von Kessler, D. P., Moon, R. T., & Beachy, P. A. (1995) · Development · doi:10.1242/dev.121.8.2337 · Cited by 203
Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation
Lustig, K. D., Kroll, K. L., Sun, E. E., et al. (1996) · Development · doi:10.1242/dev.122.12.4001 · Cited by 203
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation
Stennard, F. A., Carnac, G., & Gurdon, J. B. (1996) · Development · doi:10.1242/dev.122.12.4179 · Cited by 200
Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis
Shih, J., & Keller, R. E. (1992) · Development · doi:10.1242/dev.116.4.915 · Cited by 199
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF
MacNicol, A. M., Muslin, A. J., & Williams, L. T. (1993) · Cell · doi:10.1016/0092-8674(93)90143-e · Cited by 197
Maternal β-catenin establishes a ‘dorsal signal’ in early Xenopus embryos
Wylie, C. C., Kofron, M. J., Payne, C., Anderson, R., Hosobuchi, M., Joseph, E. M., & Heasman, J. (1996) · Development · doi:10.1242/dev.122.10.2987 · Cited by 195
TGF-β signals and a prepattern in Xenopus laevis endodermal development
Henry, G. L., Brivanlou, I. H., Kessler, D. S., Hemmati‐Brivanlou, A., & Melton, D. A. (1996) · Development · doi:10.1242/dev.122.3.1007 · Cited by 193
The origins of neural crest cells in the axolotl
Moury, J. D., & Jacobson, A. G. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90380-2 · Cited by 190
Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin
Sokol, S. Y., & Melton, D. A. (1991) · Nature · doi:10.1038/351409a0 · Cited by 189
Embryonic Development and Induction
Needham, J. (1939) · Nature · doi:10.1038/143044a0 · Cited by 188
The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesoderm
Jones, E. A., & Woodland, H. R. (1987) · Development · doi:10.1242/dev.101.3.557 · Cited by 188
Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction
Kimelman, D., Christian, J. L., & Moon, R. T. (1992) · Development · doi:10.1242/dev.116.1.1 · Cited by 179
Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevis
Symes, K., & Smith, J. C. (1987) · Development · doi:10.1242/dev.101.2.339 · Cited by 175
Transformation by v- sis Occurs by an Internal Autoactivation Mechanism
Bejcek, B. E., Li, D. Y., & Deuel, T. F. (1989) · Science · doi:10.1126/science.2551043 · Cited by 171
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
Thomsen, G. H. (1996) · Development · doi:10.1242/dev.122.8.2359 · Cited by 171
Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid
Niehrs, C., Steinbeißer, H., & Robertis, E. M. D. (1994) · Science · doi:10.1126/science.7905664 · Cited by 166
Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.
Karnovsky, A., & Klymkowsky, M. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4522 · Cited by 164
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activity
Köster, M., Plessow, S., Clement, J. H., Lorenz, A., Tiedemann, H., & Knöchel, W. (1991) · Mechanisms of Development · doi:10.1016/0925-4773(91)90027-4 · Cited by 164
Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3
Ezal, C., Marion, C. D., Steele, K. A., George, S. E., & Smith, W. C. (1997) · Development · doi:10.1242/dev.124.2.483 · Cited by 161
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development
LaBonne, C., Burke, B., & Whitman, M. (1995) · Development · doi:10.1242/dev.121.5.1475 · Cited by 161
The Formation of the Mesoderm in Urodelean Amphibians
Nieuwkoop, P. D. (1969) · Development Genes and Evolution · doi:10.1007/bf00577017 · Cited by 161
Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.
Re'em‐Kalma, Y., Lamb, T. M., & Frank, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12141 · Cited by 158
Planar Induction of Anteroposterior Pattern in the Developing Central Nervous System of Xenopus laevis
Doniach, T., Phillips, C. R., & Gerhart, J. C. (1992) · Science · doi:10.1126/science.1636091 · Cited by 158
Self-citation
Microtubule-mediated transport of organelles and localization of β-catenin to the future dorsal side of Xenopus eggs
Rowning, B. A., Wells, J. N., Wu, M., Gerhart, J. C., Moon, R. T., & Larabell, C. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1224 · Cited by 157
Self-citation
Xwnt‐8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.
Christian, J. L., Olson, D. J., & Moon, R. T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05024.x · Cited by 154
Induction of dorsal mesoderm by soluble, mature Vg1 protein
Kessler, D. S., & Melton, D. A. (1995) · Development · doi:10.1242/dev.121.7.2155 · Cited by 151
Direct and continuous assessment by cells of their position in a morphogen gradient
Gurdon, J. B., Mitchell, A., & Mahony, D. (1995) · Nature · doi:10.1038/376520a0 · Cited by 149
Neural induction in explants which have passed through a sublethal cytolysis
Holtfreter, J. (1947) · Journal of Experimental Zoology · doi:10.1002/jez.1401060205 · Cited by 149
The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development
Kinoshita, N., Minshull, J., & Kirschner, M. W. (1995) · Cell · doi:10.1016/0092-8674(95)90102-7 · Cited by 147
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
Schulte-Merker, S., Smith, J. C., & Dale, L. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06660.x · Cited by 146
Region-Specific Neural Induction of an engrailed Protein by Anterior Notochord in Xenopus
Hemmati‐Brivanlou, A., Stewart, R. M., & Harland, R. M. (1990) · Science · doi:10.1126/science.1978411 · Cited by 146
Self-citation
Presence of basic fibroblast growth factor in the early Xenopus embryo
Slack, J. M. W., & Isaacs, H. V. (1989) · Development · doi:10.1242/dev.105.1.147 · Cited by 146
β-Catenin Has Wnt-like Activity and Mimics the Nieuwkoop Signaling Center inXenopusDorsal–Ventral Patterning
Guger, K. A., & Gumbiner, B. M. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0009 · Cited by 145
Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos
Jones, C. M., Dale, L., Hogan, B. L. M., Wright, C. V. E., & Smith, J. C. (1996) · Development · doi:10.1242/dev.122.5.1545 · Cited by 145
Acquisition of developmental autonomy in the equatorial region of the Xenopus embryo
Gimlich, R. L. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90254-x · Cited by 143
The role of gsc and BMP‐4 in dorsal‐ventral patterning of the marginal zone in Xenopus: a loss‐of‐function study using antisense RNA.
Steinbeißer, H., Fainsod, A., Niehrs, C., et al. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00208.x · Cited by 137
Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis
Cui, Y., Brown, J. D., Moon, R. T., et al. (1995) · Development · doi:10.1242/dev.121.7.2177 · Cited by 137
Regulation of the fibroblast growth factor receptor in early Xenopus embryos.
Musci, T. J., Amaya, E., & Kirschner, M. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8365 · Cited by 135
Cell lineage and the induction of second nervous systems in amphibian development
Gimlich, R. L., & Cooke, J. (1983) · Nature · doi:10.1038/306471a0 · Cited by 135
Mesoderm induction in Xenopus laevis: a quantitative study using a cell lineage label and tissue-specific antibodies
Dale, L., Smith, J. C., & Slack, J. M. W. (1985) · Development · doi:10.1242/dev.89.1.289 · Cited by 135
Autonomous Endodermal Determination in Xenopus: Regulation of Expression of the Pancreatic Gene XlHbox 8
Gamer, L. W., & Wright, C. V. E. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1275 · Cited by 134
A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis
Chang, C., Wilson, P. A., Mathews, L. S., & Hemmati‐Brivanlou, A. (1997) · Development · doi:10.1242/dev.124.4.827 · Cited by 134
Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin
Jones, C. M., Armes, N., & Smith, J. C. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00751-8 · Cited by 133
Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos
Olson, D. J., Christian, J. L., & Moon, R. T. (1991) · Science · doi:10.1126/science.252.5009.1173 · Cited by 129
Planar induction of convergence and extension of the neural plate by the organizer of Xenopus
Keller, R. E., Shih, J., Sater, A. K., & Moreno, C. (1992) · Developmental Dynamics · doi:10.1002/aja.1001930303 · Cited by 125
A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm
Xu, R., Kim, J. B., Taira, M., Zhan, S.-N., Sredni, D., & Kung, H. F. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1958 · Cited by 123
Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain
Albano, R. M., Arkell, R. M., Beddington, R. S. P., & Smith, J. C. (1994) · Development · doi:10.1242/dev.120.4.803 · Cited by 123
A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos
Lemaire, P., & Gurdon, J. B. (1994) · Development · doi:10.1242/dev.120.5.1191 · Cited by 121
FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction
Cornell, R. A., Musci, T. J., & Kimelman, D. (1995) · Development · doi:10.1242/dev.121.8.2429 · Cited by 120
Restoration of the organizer after radical ablation of Hensen’s node and the anterior primitive streak in the chick embryo
Psychoyos, D., & Stern, C. D. (1996) · Development · doi:10.1242/dev.122.10.3263 · Cited by 115
Fibronectin, Mesoderm Migration, and Gastrulation in Xenopus
Winklbauer, R., & Keller, R. E. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0174 · Cited by 112
Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis
Vodicka, M. A., & Gerhart, J. C. (1995) · Development · doi:10.1242/dev.121.11.3505 · Cited by 107
Self-citation
Neural differentiation without organizer
BARTH, L. G. (1941) · Journal of Experimental Zoology · doi:10.1002/jez.1400870303 · Cited by 106
ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin
Bolce, M. E., Hemmati‐Brivanlou, A., Kushner, P. D., et al. (1992) · Development · doi:10.1242/dev.115.3.681 · Cited by 105
The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula
Stewart, R. M., & Gerhart, J. C. (1990) · Development · doi:10.1242/dev.109.2.363 · Cited by 103
Self-citation
Short-Range Signaling by Candidate Morphogens of the TGFβ Family and Evidence for a Relay Mechanism of Induction
Reilly, K. M., & Melton, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80149-x · Cited by 102
DORSALIZATION OF THE VENTRAL MARGINAL ZONE OF THE TRITURUS GASTRULA. I. AMMONIA-TREATMENT OF THE MEDIO-VENTRAL MARGINAL ZONE
Yamada, T. (1950) · Biological Bulletin · doi:10.2307/1538572 · Cited by 101
Expression of Activin mRNA during Early Development in Xenopus laevis
Dohrmann, C. E., Hemmati‐Brivanlou, A., Thomsen, G. H., Fields, A., Woolf, T. M., & Melton, D. A. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1150 · Cited by 101
Neural induction in Xenopus
Harland, R. M. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90070-j · Cited by 100
Self-citation
Localization of MAP Kinase Activity in EarlyXenopusEmbryos: Implications for Endogenous FGF Signaling
LaBonne, C., & Whitman, M. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8497 · Cited by 96
Is ventral in insects dorsal in vertebrates?
Nübler‐Jung, K., & Arendt, D. (1994) · Development Genes and Evolution · doi:10.1007/bf00188683 · Cited by 96
Transient expression of XMyoD in non-somitic mesoderm of Xenopus gastrulae
Frank, D., & Harland, R. M. (1991) · Development · doi:10.1242/dev.113.4.1387 · Cited by 94
Self-citation
Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus
Sokol, S. Y., & Melton, D. A. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90073-p · Cited by 87
Patterns of microtubule polymerization relating to cortical rotation in Xenopus laevis eggs
Houliston, E., & Elinson, R. P. (1991) · Development · doi:10.1242/dev.112.1.107 · Cited by 87
cDNA cloning and developmental expression of fibroblast growth factor receptors from Xenopus laevis.
Friesel, R. E., & Dawid, I. B. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.5.2481 · Cited by 87
The epithelium of the dorsal marginal zone of Xenopus has organizer properties
Shih, J., & Keller, R. E. (1992) · Development · doi:10.1242/dev.116.4.887 · Cited by 87
Axial structure development in ultraviolet-irradiated (notochord-defective) amphibian embryos
Youn, B. W., & Malacinski, G. M. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90479-6 · Cited by 84
Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation
Fujisue, M., Kobayakawa, Y., & Yamana, K. (1993) · Development · doi:10.1242/dev.118.1.163 · Cited by 84

Research works printed but not linked: 16

Boucaut JC, 1996, Int. J. Dev. Biol., 40, 675
Cooke J, 1985, J. Embryol. Exp. Morphol., 88, 135
Dale L, 1985, J. Embryol. Exp. Morphol., 89, 289
Dosch R, 1997, Entwicklungsbiol. Abstr., 54
10.1016/0092-8674(93)90682-G · DOI
Harland RM. 1996. Neural induction inXenopus. InMolecular and Cellular Approaches to Neural Development, ed. WM Cowan, TM Jessell, SL Zipursky. Oxford: Oxford Univ. Press. In press
Holtfreter J, 1951, Growth, 3, 117
Holtfreter J, Hamburger V. 1955. Embryogenesis: progressive differentiation—amphibians. InAnalysis of Development, ed. BH Willier, PA Weiss, V Hamburger, pp. 230–96. New York: Haffner. Reprinted 1971
Isaacs HV, 1995, J. Dev. Biol., 39, 575
Kageura H, 1997, Development.
Keller R, 1992, Dev. Suppl.
McMahon JA, 1997, Development.
Nieuwkoop PD, 1950, Arch. Biol., 61, 113
Schulte-Merker S, 1997, Abstr. Ges. Entwicklungsbiol., 13
Smith JC, 1983, J. Embryol. Exp. Morphol., 78, 299
Zoltewicz JS, 1997, Dev. Biol.

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See all 839

Authors: Harland, R., & Gerhart, J.
Affiliations: University of California, Berkeley (US)
ORCID: Harland, Richard
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 1997-11
Volume: 13
Issue: 1
Pages: 611-667
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.13.1.611
OpenAlex: W2115686163
Cited by: 839
References: 249
Citations by year: 2026: 6 · 2025: 15 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 9 · 2018: 17 · 2017: 13 · 2016: 20 · 2015: 17 · 2014: 13 · 2013: 11 · 2012: 18
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM 19363, GM 42341, R01GM042341, R01GM049346, GM 49346)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords: Spemann organizer, amphibian embryos, TGF-beta signaling, Wnt signaling, maternal factors, competence domains, dorsalization, BMP antagonists, neural induction, dorsal mesoderm, gastrulation, blastula
MeSH terms: Amphibians, Animals, Blastocyst, Cell Differentiation, Endoderm, Gastrula, Mesoderm, Signal Transduction

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