The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
CELL BIOLOGY OF MYCOBACTERIUM TUBERCULOSIS PHAGOSOME
Abstract
▪ Abstract Phagocytosis and phagolysosome biogenesis represent fundamental biological processes essential for proper tissue homeostasis, development, elimination of invading microorganisms, and antigen processing and presentation. Phagosome formation triggers a preprogramed pathway of maturation into the phagolysosome, a process controlled by Ca 2+and the regulators of organellar trafficking centered around the small GTP-binding proteins Rabs and their downstream effectors, including lipid kinases, organellar tethering molecules, and membrane fusion apparatus. Mycobacterium tuberculosis is a potent human pathogen parasitizing macrophages. It interferes with the Rab-controlled membrane trafficking and arrests the maturing phagosome at a stage where no harm can be done to the pathogen while the delivery of nutrients and membrane to the vacuole harboring the microorganism continues. This process, referred to as the M. tuberculosis phagosome maturation arrest or inhibition of phagosome-lysosome fusion, is critical for M. tuberculosis persistence in human populations. It also provides a general model system for dissecting the phagolysosome biogenesis pathways. Here we review the fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation.
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Cites
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Cited by
Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252
Self-citationAutophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Self-citationM. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells
van der Wel, N., Hava, D., Houben, D., Fluitsma, D., van Zon, M., Pierson, J., Brenner, M., & Peters, P. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.059 · Cited by 960
Autophagy, Immunity, and Microbial Adaptations
Deretic, V., & Levine, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.016 · Cited by 865
Self-citationPhagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death
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Metadata
- Authors
- Vergne, I., Chua, J., Singh, S. B., & Deretic, V.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2004-11-01
- Volume
- 20
- Issue
- 1
- Pages
- 367-394
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2160131728
- Cited by
- 440
- References
- 113
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vergne, I., Chua, J., Singh, S. B., & Deretic, V. (2004). CELL BIOLOGY OF MYCOBACTERIUM TUBERCULOSIS PHAGOSOME. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.20.010403.114015
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