The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MECHANISMS OF APOPTOSIS THROUGH STRUCTURAL BIOLOGY
Abstract
Apoptosis plays a central role in the development and homeostasis of metazoans. Research in the past two decades has led to the identification of hundreds of genes that govern the initiation, execution, and regulation of apoptosis. An earlier focus on the genetic and cell biological characterization has now been complemented by systematic biochemical and structural investigation, giving rise to an unprecedented level of clarity in many aspects of apoptosis. In this review, we focus on the molecular mechanisms of apoptosis by synthesizing available biochemical and structural information. We discuss the mechanisms of ligand binding to death receptors, actions of the Bcl-2 family of proteins, and caspase activation, inhibition, and removal of inhibition. Although an emphasis is given to the mammalian pathways, a comparative analysis is applied to related mechanistic information in Drosophila and Caenorhabditis elegans.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
The Bcl2 family: regulators of the cellular life-or-death switch
Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
IAP proteins: blocking the road to death's door
Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756
Huang, Y., Rich, R. L., Myszka, D. G., & Wu, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310061200 · Cited by 152
Cited by
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
Yu, H., Guo, P., Xie, X., Wang, Y., & Chen, G. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13008 · Cited by 710
Cold atmospheric plasma, a novel promising anti-cancer treatment modality
Yan, D., Sherman, J. H., & Keidar, M. (2017) · Oncotarget · doi:10.18632/oncotarget.13304 · Cited by 543
The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation
Park, H. H., Lo, Y.-C., Lin, S.-C., Wang, L., Yang, J. K., & Wu, H. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141656 · Cited by 526
Evolving Concepts of Apoptosis in Idiopathic Pulmonary Fibrosis
Thannickal, V. J., & Horowitz, J. C. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-001tk · Cited by 364
Apoptosome Structure, Assembly, and Procaspase Activation
Yuan, S., & Akey, C. W. (2013) · Structure · doi:10.1016/j.str.2013.02.024 · Cited by 281
Metadata
- Authors
- Yan, N., & Shi, Y.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2005-11-01
- Volume
- 21
- Issue
- 1
- Pages
- 35-56
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2158882381
- Cited by
- 208
- References
- 7
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yan, N., & Shi, Y. (2005). MECHANISMS OF APOPTOSIS THROUGH STRUCTURAL BIOLOGY. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.21.012704.131040
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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