The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Biology of Cancer Stem Cells
Abstract
Cancers originally develop from normal cells that gain the ability to proliferate aberrantly and eventually turn malignant. These cancerous cells then grow clonally into tumors and eventually have the potential to metastasize. A central question in cancer biology is, which cells can be transformed to form tumors? Recent studies elucidated the presence of cancer stem cells that have the exclusive ability to regenerate tumors. These cancer stem cells share many characteristics with normal stem cells, including self-renewal and differentiation. With the growing evidence that cancer stem cells exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. This new paradigm of oncogenesis has been validated in a growing list of tumors. Studies of normal and cancer stem cells from the same tissue have shed light on the ontogeny of tumors. That signaling pathways such as Bmi1 and Wnt have similar effects in normal and cancer stem cell self-renewal suggests that common molecular pathways regulate both populations. Understanding the biology of cancer stem cells will contribute to the identification of molecular targets important for future therapies.
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Citations
Cites
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BackgroundBmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
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Cited by
Hallmarks of Cancer: The Next Generation
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The epigenetics of epithelial-mesenchymal plasticity in cancer
Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,163
Roles of the EZH2 histone methyltransferase in cancer epigenetics
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Metadata
- Authors
- Lobo, N. A., Shimono, Y., Qian, D., & Clarke, M. F.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 675-699
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2127107445
- Cited by
- 1,043
- References
- 20
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lobo, N. A., Shimono, Y., Qian, D., & Clarke, M. F. (2007). The Biology of Cancer Stem Cells. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.22.010305.104154
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
