The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Deciphering the Genetic Basis of Alzheimer's Disease
Abstract
A remarkable rise in life expectancy during the past century has made Alzheimer's disease (AD) the most common form of progressive cognitive failure in humans. Compositional analyses of the classical brain lesions, the senile (amyloid) plaques and neurofibrillary tangles, preceded and has guided the search for genetic alterations. Four genes have been unequivocally implicated in inherited forms of AD, and mutations or polymorphisms in these genes cause excessive cerebral accumulation of the amyloid ß-protein and subsequent neuronal and glial pathology in brain regions important for memory and cognition. This understanding of the genotype-to-phenotype conversions of familial AD has led to the development of pharmacological strategies to lower amyloid ß-protein levels as a way of treating or preventing all forms of the disease.
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Alzheimer's Disease: Genes, Proteins, and Therapy
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Self-citationNotch Signaling: Cell Fate Control and Signal Integration in Development
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Cited by
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980
Genetic variation, classification and ‘race’
Jorde, L. B., & Wooding, S. P. (2004) · Nature Genetics · doi:10.1038/ng1435 · Cited by 637
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Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation
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Metadata
- Authors
- Selkoe, D. J., & Podlisny, M. B.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2002-09
- Volume
- 3
- Issue
- 1
- Pages
- 67-99
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2117513966
- Cited by
- 294
- References
- 158
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Selkoe, D. J., & Podlisny, M. B. (2002). Deciphering the Genetic Basis of Alzheimer's Disease. Annual Review of Genomics and Human Genetics. https://doi.org/10.1146/annurev.genom.3.022502.103022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
