The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
F ROM Z EBRAFISH TO H UMAN: Modular Medical Models
Abstract
▪ Abstract Genetic screens in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio clarified the logic of metazoan development by revealing critical unitary steps and pathways to embryogenesis. Can genetic screens similarly organize medicine? We here examine human diseases that resemble mutations in Danio rerio, the zebrafish, the one vertebrate species for which large-scale genetic screens have been performed and extensively analyzed. Zebrafish mutations faithfully phenocopy many human disorders. Each mutation, once cloned, provides candidate genes and pathways for evaluation in the human. The collection of mutations in their entirety potentially provides a medical taxonomy, one based in developmental biology and genetics.
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Cites
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Cited by
Strähle, U., Scholz, S., Geisler, R., Greiner, P., Hollert, H., Rastegar, S., Schumacher, A., Selderslaghs, I., Weiss, C., Witters, H., et al. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.06.121 · Cited by 673
Zebrafish: A new model on the pharmaceutical catwalk
Langheinrich, U. (2003) · BioEssays · doi:10.1002/bies.10326 · Cited by 332
Using the Zebrafish as a Genetic Model to Study Erythropoiesis
Zhang, Y., Chen, M., & Chen, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910475 · Cited by 25
Metadata
- Authors
- Shin, J. T., & Fishman, M. C.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2002-09
- Volume
- 3
- Issue
- 1
- Pages
- 311-340
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2171928686
- Cited by
- 261
- References
- 12
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shin, J. T., & Fishman, M. C. (2002). F ROM Z EBRAFISH TO H UMAN: Modular Medical Models. Annual Review of Genomics and Human Genetics. https://doi.org/10.1146/annurev.genom.3.031402.131506
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
