The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Immunological and Inflammatory Functions of the Interleukin-1 Family
Abstract
More than any other cytokine family, the interleukin (IL)-1 family is closely linked to the innate immune response. This linkage became evident upon the discovery that the cytoplasmic domain of the IL-1 receptor type I is highly homologous to the cytoplasmic domains of all Toll-like receptors (TLRs). Thus, fundamental inflammatory responses such as the induction of cyclooxygenase type 2, increased expression of adhesion molecules, or synthesis of nitric oxide are indistinguishable responses of both IL-1 and TLR ligands. Both families nonspecifically affect antigen recognition and lymphocyte function. IL-1beta is the most studied member of the IL-1 family because of its role in mediating autoinflammatory diseases. Although the TLR and IL-1 families evolved to assist in host defense against infection, unlike the TLR family, the IL-1 family also includes members that suppress inflammation, both specifically within the IL-1 family but also nonspecifically for TLR ligands and the innate immune response.
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“Since IL-1β, in turn, is known to induce a proinflammatory Mp phenotype (15,21)”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [21]
In the citing paper
“The NLRP-3 inflammasome plays a role in the pathophysiology of many inflammatory diseases, including obesity, insulin resistance, and diabetes (21,31–35).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [21]
Citations
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Cited by
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
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Inflammasomes: mechanism of assembly, regulation and signalling
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Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,087
Activation and regulation of the inflammasomes
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Metadata
- Authors
- Dinarello, C. A.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Dinarello, Charles A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2009-04-01
- Volume
- 27
- Issue
- 1
- Pages
- 519-550
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2165275387
- Cited by
- 3,466
- References
- 170
- Citations by year
- 2026: 95 · 2025: 169 · 2024: 195 · 2023: 185 · 2022: 209 · 2021: 183 · 2020: 199 · 2019: 202 · 2018: 231 · 2017: 219 · 2016: 198 · 2015: 223 · 2014: 244 · 2013: 227 · 2012: 206
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI‑15614)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-1 family, innate immunity, inflammation, Toll-like receptors, IL-1 receptor type I, IL-1β, autoinflammatory disease, adhesion molecules, nitric oxide, antigen recognition, lymphocyte function, anti-inflammatory cytokines
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, B-Lymphocytes, Carrier Proteins, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Interleukin-1, Signal Transduction, Receptors, Interleukin-1, Receptors, Purinergic P2, Caspase 1, Toll-Like Receptors, Receptors, Purinergic P2X7
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