Cited by 1,545Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyReceptor Mechanisms and Signaling

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THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

Nelms, Keats, Keegan, Achsah D., Zamorano, José, Ryan, John J., Paul, William E.·1999·Annual Review of Immunology

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Abstract

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4R alpha chain and the common gamma chain (gamma c), resulting in a series of phosphorylation events mediated by receptor-associated kinases. In turn, these cause the recruitment of mediators of cell growth, of resistance to apoptosis, and of gene activation and differentiation. Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various mechanisms through which receptor function is modulated. We particularly emphasize the modular nature of the receptor and the specialization of different receptor regions for distinct functions, most notably the independent regulation of cell growth and gene activation.

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Crossref · 10.1146/annurev.immunol.17.1.701

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STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
SH2 domains recognize specific phosphopeptide sequences
Songyang, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90404-e · Cited by 2,620
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,237
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Proteins regulating Ras and its relatives
Boguski, M. S., & McCormick, F. P. (1993) · Nature · doi:10.1038/366643a0 · Cited by 1,905
PI3K: Downstream AKTion Blocks Apoptosis
Franke, T. F., Kaplan, D. R., & Cantley, L. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81883-8 · Cited by 1,665
Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574

Show all 190 references

Research works printed but not linked: 6

Zhou M-M, 1995, Nature, 92, 7784
Downward J, 1996, Cancer Surv., 27, 87
Marais R, 1996, Cancer Surv., 27, 101
Salcini AE, 1994, Oncogene, 9, 2827
10.1074/jbc.272.34.21403 · DOI
10.1210/me.11.2.251 · DOI

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Background
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BackgroundInfluential
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Background
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Background
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Background
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Background
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BackgroundInfluential
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Background
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Background
The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions
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Background
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BackgroundInfluential
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Background
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Background
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“IL-4 is a cytokine that can suppress the Th1-type response, maintaining persistent HBV replication and promoting immune tolerance [32, 76, 77].”
Background
Biologic Therapy and Severe Asthma in Children
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“IL-4R type I is characterized by the link between the common IL-4Rα with the γc chain and is expressed on the surface of hematopoietic cells.”
BackgroundInfluential
The Role of Cytokines in the Mechanism of Adverse Drug Reactions
Masson, M. J., Collins, L. A., & Pohl, L. R. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00663-0_8 · Cited by 22
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da Silva, A. G. L. S., Campello‐Costa, P., Linden, R., & Sholl‐Franco, A. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.03.003 · Cited by 22
“It is involved in diverse biological roles, such as maturation and proliferation of immune cells, and the control of immunoglobulin class switching (Nelms et al., 1999; Ansel et al., 2006).”
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IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population
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“The IL-4 receptor alpha is a vital element through which extracellular IL-4 and IL-13 cytokines signaling are transduced into alternative cell-specific responses, affecting many processes including the immune response.[1,2,4] This receptor mediates in B lymphocytes the class-switch recombination mechanism and”
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Low expression of the interleukin (IL)‐4 receptor alpha chain and reduced signalling via the IL‐4 receptor complex in human neonatal B cells
Tian, C., Kron, G. K., Dischert, K. M., Higginbotham, J. N., & Crowe, J. E. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02405.x · Cited by 22
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Mirel, D. B., Barcellos, L. F., Wang, J., Hauser, S. L., Oksenberg, J. R., & Erlich, H. A. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364048 · Cited by 22
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al-Ramadi, B. K., Welte, T., Fernández-Cabezudo, M. J., Galadari, S., Dittel, B. N., Fu, X.-Y., & Bothwell, A. L. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.6827 · Cited by 22
“Furthermore, no association between any of the T cell-expressed Src-tyrosine kinases and the IL-4R complex has been reported (39).”
Background
IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor ComplexPreprint
Losman, J. A., Chen, X. P., Jiang, H., Pan, P., Kashiwada, M., Giallourakis, C. C., Cowan, S., Foltenyi, K., & Rothman, P. B. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.405 · Cited by 22
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CD200R/Foxp3-mediated signalling regulates microglial activation
Yi, M., Zhang, E., Kim, J.-J., Baek, H., Shin, N., Kim, S., Kim, S. R., Kim, H., Lee, S. J., Park, J. B., et al. (2016) · Scientific Reports · doi:10.1038/srep34901 · Cited by 21
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“IL-4 induces leukocyte survival([18]) – which has further pathological effects through its receptor (IL-4Ra) – either by type-1 signaling complex – which is critical for Th2 differentiation and also alternatively activated macrophage – or type 2 signaling complex, which belongs to nonhematopoietic cells.([19]) To the…”
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The transcriptional regulator NFIL3 controls IgE production.
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Morris, K., Prentis, P. J., O’Meally, D., Pavasovic, A., Taylor–Brown, A., Timms, P., Belov, K., & Polkinghorne, A. (2014) · Australian Journal of Zoology · doi:10.1071/zo13105 · Cited by 21
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Background
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Ford, A. Q., Heller, N. M., Stephenson, L. M., Boothby, M. R., & Keegan, A. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803266 · Cited by 21
“IL-4 induces expression of MHC class II on macrophages and induces the expression of genes associated with parasitic infections (2, 3).”
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“By binding to IL-4Rα, it dimers with a common gamma chain (γc) to produce a type 1 signaling complex located primarily in hematopoietic cells [34].”
Background
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Bottini, N., Otsu, A., Borgiani, P., Saccucci, P., Stefanini, L., Greco, E., Fontana, L., Hopkins, J., & Mao, X. ‐. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00002.x · Cited by 21
“Several tyrosine phosphorylation phenomena are activated following IL-4 stimulation, and many pathways activated by the IL-4 receptor are similar to those activated by insulin (15), whose signal transduction is modulated by the ACP1 S isoform.”
Background
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Background
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“BALB/c, Stat4-deficient (17) BALB/c, and Stat6-deficient (18) BALB/c mice (The Jackson Laboratory, Bar Harbor, ME), IL-4R -deficient BALB/c (19), tenth backcross TCR-C -deficient mice (20), IL-4 greenenhanced transcript (4get)4 IL-4 reporter mice (21), and CTLA-4-deficient mice (22) were kept in the University of Cali…”
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Upon Prolonged Allergen Exposure IL-4 and IL-4Rα Knockout Mice Produce Specific IgE Leading to Anaphylaxis
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“Since STAT6 is an important component for intracellular signaling through the shared IL-4 and IL-13 receptor [”
Background
PU.1 is required for transcriptional activation of the Stat6 response element in the Igϵ promoter
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Background
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DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function
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“ERK activity is involved in IL-4 signaling [23], and inhibition of ERK activity reduces the up-regulation of DC-SIGN by modifying the signaling capability of IL-4 [22].”
Background
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“downstream phosphorylation and activation of STAT6 transcriptional factor, and IRS-2 (Insulin Response Substrate) signaling with consequential activation of downstream kinase Akt, crucial for cell proliferation and apoptosis resistance [65].”
Background
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“Interleukin 10 (IL-10) is a potent cytokine that is produced by Th2 lymphocytes (2,3).”
Background
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“Macrophages have been described along a continuum of gene expression patterns and functional status (Mantovani et al., 2002; Montaner et al., 1999; Nelms et al., 1999; Stout et al., 2004).”
Background
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Background
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“IL-4 is responsible for the humoral immune response, has local antitumor activity, suppresses the production of inflammatory cytokines (IL-8, TNF-α), and also regulates multiple biological processes, such as proliferation, differentiation, and apoptosis in various cell types [8].”
Background

Authors: Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E.
Affiliations: National Institutes of Health (US)
Corresponding author: Nelms, Keats
Paul, William E.
ORCID: Keegan, Achsah D.
Ryan, John J.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1999-04
Volume: 17
Issue: 1
Pages: 701-738
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.17.1.701
OpenAlex: W2144120552
Cited by: 1,545
References: 190
Citations by year: 2026: 17 · 2025: 27 · 2024: 52 · 2023: 36 · 2022: 54 · 2021: 43 · 2020: 50 · 2019: 44 · 2018: 54 · 2017: 49 · 2016: 52 · 2015: 56 · 2014: 72 · 2013: 52 · 2012: 55
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: IL-4, IL-4 receptor, common gamma chain, receptor signaling, receptor phosphorylation, cell growth regulation, apoptosis resistance, gene activation, T cell differentiation, cytokine signaling
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Phosphoproteins, Signal Transduction, Trans-Activators, Interleukin-4, Protein Tyrosine Phosphatases, Calcium-Calmodulin-Dependent Protein Kinases, Mice, Knockout, Receptors, Interleukin-4, Mitogen-Activated Protein Kinases, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, STAT6 Transcription Factor, Mice, Insulin Receptor Substrate Proteins

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THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

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