THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions

STATs and Gene Regulation

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SH2 domains recognize specific phosphopeptide sequences

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Protein modules and signalling networks

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A family of cytokine-inducible inhibitors of signalling

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Proteins regulating Ras and its relatives

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PI3K: Downstream AKTion Blocks Apoptosis

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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

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Essential role of Stat6 in IL-4 signalling

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Acquisition of lymphokine-producing phenotype by CD4+ T cells

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Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

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A new protein containing an SH2 domain that inhibits JAK kinases

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STATs: Signal Transducers and Activators of Transcription

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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Generation and Analysis of Interleukin-4 Deficient Mice

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A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

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Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

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Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

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Structure and function of a new STAT-induced STAT inhibitor

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Crystal Structure of the Tyrosine Phosphatase SHP-2

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The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

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An Interleukin-4-Induced Transcription Factor: IL-4 Stat

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Role of IRS-2 in insulin and cytokine signalling

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CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

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Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

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B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

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A protein tyrosine kinase in the interferon alpha/beta signaling pathway.

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The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

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Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

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Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

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Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

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Interaction of IL-2Rβ and γ c Chains with Jak1 and Jak3: Implications for XSCID and XCID

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Phosphatidylinositol 3‐kinase

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

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The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

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Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

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Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

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Cytokine Receptors and Signal Transduction

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Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

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Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

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Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

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IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

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A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling

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Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

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Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

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A Molecular Basis for Insulin Resistance

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Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

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Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

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The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

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Transcriptional regulation by MAP kinases

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

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Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

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Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

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Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family

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Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor.

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IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

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Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms

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A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

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The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

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Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

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Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

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p62 : A Constitutively Tyrosine-Phosphorylated, GAP-Associated Protein in Chronic Myelogenous Leukemia Progenitor Cells

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

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Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

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Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma

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Identification of the Abl- and rasGAP-Associated 62 kDa Protein as a Docking Protein, Dok

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Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

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Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

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An interleukin 4 (IL-4)-independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice

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PI 3‐kinase: structural and functional analysis of intersubunit interactions.

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Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

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