The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
Abstract
Class switch recombination (CSR) and somatic hypermutation (SHM) have been considered to be mediated by different molecular mechanisms because both target DNAs and DNA modification products are quite distinct. However, involvement of activation-induced cytidine deaminase (AID) in both CSR and SHM has revealed that the two genetic alteration mechanisms are surprisingly similar. Accumulating data led us to propose the following scenario: AID is likely to be an RNA editing enzyme that modifies an unknown pre-mRNA to generate mRNA encoding a nicking endonuclease specific to the stem-loop structure. Transcription of the S and V regions, which contain palindromic sequences, leads to transient denaturation, forming the stem-loop structure that is cleaved by the AID-regulated endonuclease. Cleaved single-strand tails will be processed by error-prone DNA polymerase-mediated gap-filling or exonuclease-mediated resection. Mismatched bases will be corrected or fixed by mismatch repair enzymes. CSR ends are then ligated by the NHEJ system while SHM nicks are repaired by another ligation system.
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Cites
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Cited by
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
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The AID enzyme induces class switch recombination in fibroblasts
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Self-citation
Metadata
- Authors
- Honjo, T., Kinoshita, K., & Muramatsu, M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2002-04
- Volume
- 20
- Issue
- 1
- Pages
- 165-196
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2152078686
- Cited by
- 598
- References
- 8
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Honjo, T., Kinoshita, K., & Muramatsu, M. (2002). Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.20.090501.112049
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