The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
Abstract
TNF and TNFR family proteins play important roles in the control of cell death, proliferation, autoimmunity, the function of immune cells, or the organogenesis of lymphoid organs. Recently, novel members of this large family have been identified that have critical functions in immunity and that couple lymphoid cells with other organ systems such as bone morphogenesis and mammary gland formation in pregnancy. The TNF-family molecule RANK-L (RANK-L, TRANCE, ODF) and its receptor RANK are key regulators of bone remodeling, and they are essential for the development and activation of osteoclasts. Intriguingly, RANK-L/RANK interactions also regulate T cell/dendritic cell communications, dendritic cell survival, and lymph node formation; T cell–derived RANK-L can mediate bone loss in arthritis and periodontal disease. Moreover, RANK-L and RANK are expressed in mammary gland epithelial cells, and they control the development of a lactating mammary gland during pregnancy and the propagation of mammalian species. Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis.
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Cites
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Cited by
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“It is now clear that RANKL and osteoprotegerin are the key regulators of bone remodeling and are directly in- volved in the differentiation, activation and survival of osteoclasts and osteoclast precursors (2, 129, 261).”
BackgroundInfluential
Metadata
- Authors
- Theill, L. E., Boyle, W. J., & Penninger, J. M.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2002-04
- Volume
- 20
- Issue
- 1
- Pages
- 795-823
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2170384111
- Cited by
- 819
- References
- 128
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Theill, L. E., Boyle, W. J., & Penninger, J. M. (2002). RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.20.100301.064753
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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