The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
A CENTRAL ROLE FOR CENTRAL TOLERANCE
Abstract
Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs). TRA expression in mTECs mirrors virtually all tissues of the body, irrespective of developmental or spatio-temporal expression patterns. This review summarizes current knowledge on the cellular and molecular regulation of TRA expression in mTECs, outlines relevant mechanisms of antigen presentation and modes of tolerance induction, and discusses implications for the pathogenesis of autoimmune diseases and other biological processes such as fertility, pregnancy, puberty, and tumor defense.
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Cites
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
THE NOD MOUSE: A Model of Immune Dysregulation
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Cross-Presentation, Dendritic Cells, Tolerance and Immunity
Heath, W. R., & Carbone, F. R. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.47 · Cited by 882
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
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Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment
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Cited by
Blair, P. A., Noreña, L. Y., Flores-Borja, F., Rawlings, D. J., Isenberg, D. A., Ehrenstein, M. R., & Mauri, C. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.009 · Cited by 1,574
A guide to antigen processing and presentation
Pishesha, N., Harmand, T. J., & Ploegh, H. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00707-2 · Cited by 805
Aschenbrenner, K., D'Cruz, L. M., Vollmann, E. H., Hinterberger, M., Emmerich, J., Swee, L. K., Rolink, A., & Klein, L. (2007) · Nature Immunology · doi:10.1038/ni1444 · Cited by 580
Self-citationBennett, J. M., Reeves, G., Billman, G. E., & Sturmberg, J. P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00316 · Cited by 531
Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.015 · Cited by 503
Metadata
- Authors
- Kyewski, B., & Klein, L.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2006-04-01
- Volume
- 24
- Issue
- 1
- Pages
- 571-606
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2138319166
- Cited by
- 748
- References
- 12
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kyewski, B., & Klein, L. (2006). A CENTRAL ROLE FOR CENTRAL TOLERANCE. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.23.021704.115601
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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