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TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T R, Coffman, R L·1989·Annual Review of Immunology

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Abstract

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More

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Authors: Mosmann, T. R., & Coffman, R. L.
ORCID: Mosmann, T R
Coffman, R L
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1989-04
Volume: 7
Issue: 1
Pages: 145-173
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.iy.07.040189.001045
OpenAlex: W2172466148
Cited by: 7,692
References: 103
Citations by year: 2026: 43 · 2025: 73 · 2024: 90 · 2023: 70 · 2022: 73 · 2021: 112 · 2020: 109 · 2019: 102 · 2018: 124 · 2017: 142 · 2016: 147 · 2015: 161 · 2014: 198 · 2013: 208 · 2012: 228
FWCI: 60.35
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: Th1 cells, Th2 cells, lymphokine secretion, T helper cell function, CD8+ T cell exhaustion, inhibitory receptors, chronic infection, tumor immunology
MeSH terms: Animals, Antibody Formation, Cell Differentiation, T-Lymphocytes, Helper-Inducer, Lymphokines, Mice

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TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

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