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The Molecular Mechanism of Insulin Action
Abstract
Insulin initiates its action by binding to a glycoprotein receptor on the surface of the cell. This receptor consists of an alpha-subunit, which binds the hormone, and a beta-subunit, which is an insulin-stimulated, tyrosine-specific protein kinase. Activation of this kinase is believed to generate a signal that eventually results in insulin's action on glucose, lipid, and protein metabolism. The growth-promoting effects of insulin appear to occur through activation of receptors for the family of related insulin-like growth factors. Both genetic and acquired abnormalities in the number of insulin receptors, the activity of the receptor kinase, and the various post-receptor steps in insulin action occur in disease states leading to tissue resistance to insulin action.
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Citations
Cited by
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Le Roith, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360907 · Cited by 897
A prospective study of obesity and cancer risk (Sweden)
Wolk, A., Gridley, G., Svensson, M., Nyrén, O., McLaughlin, J. K., Fraumeni, J. F., & Adami, H.-O. (2001) · Cancer Causes & Control · doi:10.1023/a:1008995217664 · Cited by 581
The insulin receptor and the molecular mechanism of insulin action.
Kahn, C. R., & White, M. F. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113711 · Cited by 432
Self-citation
Metadata
- Authors
- Kahn, C. R.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1985-02
- Volume
- 36
- Issue
- 1
- Pages
- 429-451
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2176848385
- Cited by
- 431
- References
- 0
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- closed
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