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Cited by 581Cancer Risks and FactorsObesity, Physical Activity, DietGlobal Cancer Incidence and Screening

A prospective study of obesity and cancer risk (Sweden)

Wolk, Alicja, Gridley, Gloria, Svensson, Malin, Nyrén, Olof, McLaughlin, Joseph K., Fraumeni, Joseph F., Adami, Hans-Olov·2001·Cancer Causes & Control
DOI 10.1023/a:1008995217664
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Abstract

Objective [corrected] We evaluated the relation between obesity and the risks for various forms of cancer.Methods In a population-based cohort of 28,129 hospital patients (8165 men, 19,964 women) with any discharge diagnosis of obesity (9557 only diagnosis, 5266 primary, 13,306 secondary) during 1965-1993, cancer incidence was ascertained through 1993 by record linkage to the nationwide Swedish Cancer Registry. Cancer risk was estimated using the standardized incidence ratio (SIR, with 95% confidence interval), which is the ratio of the observed number of cancers to that expected.Results Overall, a 33% excess incidence of cancer was seen in obese persons, 25% in men and 37% in women. Significant risk elevations were observed for cancers of the small intestine (SIR = 2.8; 95% CI 1.6-4.5), colon (1.3; 1.1-1.5), gallbladder (1.6; 1.1-2.3), pancreas (1.5; 1.1-1.9), larynx (2.1; 1.1-3.5), renal parenchyma (2.3; 1.8-2.8), bladder (1.2; 1.0-1.6), cervix uteri (1.4; 1.1-1.9), endometrium (2.9; 2.5-3.4), ovary (1.2; 1.1-1.5), brain (1.5; 1.2-1.9), and connective tissue (1.9; 1.1-3.0), and for lymphomas (1.4; 1.0-1.7), with higher risk observed for Hodgkin's disease only in men (3.3; 1.4-6.5) and for non-Hodgkin's lymphoma only in women (1.6; 1.2-2.1). The association of obesity with risk of breast, prostate and pancreas cancers was modified by age.Conclusions Obesity is associated with more forms of cancer than previously reported.

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  • Both older males and females are at increased risk of hepatobiliary and genitourinary cancers.

    “whilst both older males and females are at increased risk of hepatobiliary (gallbladder and pancreatic), and genitourinary (renal, bladder, uterine, cervical and prostate) cancers [33].”

    From Obesity pharmacotherapy in older adults: a narrative review of evidence (2025) · cites this paper as [33]

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Authors
Wolk, A., Gridley, G., Svensson, M., Nyrén, O., McLaughlin, J. K., Fraumeni, J. F., & Adami, H.-O.
Affiliations
  • Karolinska Institutet (SE)
  • National Cancer Institute (US)
  • International Epidemiology Institute (US)
Corresponding author
Wolk, Alicja
ORCID
Venue
Cancer Causes & Control
Publisher
Springer Science and Business Media LLC
Published
2001-01
Volume
12
Issue
1
Pages
13-21
ISSN
  • 0957-5243 (ISSN-L)
  • 1573-7225
DOI
10.1023/a:1008995217664
OpenAlex
W1522687886
Cited by
581
References
77
Citations by year
2026: 6 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 14 · 2021: 9 · 2020: 21 · 2019: 19 · 2018: 19 · 2017: 13 · 2016: 23 · 2015: 29 · 2014: 33 · 2013: 40 · 2012: 44
FWCI
7.79
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Causes & Control (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01cp085636-006008)
  • National Cancer Institute (N01-CP-85636)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
obesity, cancer risk, cancer incidence, standardized incidence ratio, small intestine neoplasms, colon cancer, gallbladder cancer, pancreatic cancer, laryngeal cancer, bladder cancer, cervical cancer, endometrial cancer, ovarian cancer, brain cancer, Hodgkin's disease, non-Hodgkin lymphoma, breast cancer, prostate cancer
MeSH terms
Adolescent, Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Obesity, Patient Discharge, Population Surveillance, Registries, Risk Factors, Sweden, Comorbidity, Incidence, Prevalence, Sex Distribution

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