Clinical Pharmacology of Nicotine
Abstract
Nicotine is the primary reason why people consume tobacco products and it may contribute to causation of tobacco-related diseases. This chapter reviews the human pharmacology of nicotine, the evidence for a role of nicotine in human disease, and the use of nicotine (gum) as a therapeutic agent in smoking cessation therapy.
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The delivery of nicotine to the brain and the consequent pleasurable effects experienced by the smoker are rapid.
“Correspondingly, the delivery of nicotine to the brain and the consequent pleasurable effects experienced by the smoker are also rapid [4].”
From A Randomised Study to Investigate the Nicotine Pharmacokinetics of Oral Nicotine Pouches and a Combustible Cigarette (2022) · cites this paper as [4]
Cites
Signs and Symptoms of Tobacco Withdrawal
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Cryer, P. E., Haymond, M. W., Santiago, J. V., & Shah, S. D. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951101 · Cited by 1,101 · see citing works
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Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation
Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050069n · Cited by 930 · see citing works
Nicotine withdrawal versus other drug withdrawal syndromes: similarities and dissimilarities
HUGHES, J. R., HIGGINS, S. T., & BICKEL, W. K. (1994) · Addiction · doi:10.1111/j.1360-0443.1994.tb03744.x · Cited by 312 · see citing works
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Clonidine, depression, and smoking cessation
Hughes, J. R. (1988) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1988.03720190069036 · Cited by 95 · see citing works
McEwan, M., Azzopardi, D., Gale, N., Camacho, O. M., Hardie, G., Fearon, I. M., & Murphy, J. (2022) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-021-00742-9 · Cited by 70 · see citing works
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- Authors
- Benowitz, N. L.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1986-02
- Volume
- 37
- Issue
- 1
- Pages
- 21-32
- ISSN
- 0066-4219
- 1545-326X
- Cited by
- 211
- References
- 2
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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