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Cigarette smoke inhalation impairs angiogenesis in early bone healing processes and delays fracture union
Open accessAbstract
Aims: Cigarette smoking has a negative impact on the skeletal system, causes a decrease in bone mass in both young and old patients, and is considered a risk factor for the development of osteoporosis. In addition, it disturbs the bone healing process and prolongs the healing time after fractures. The mechanisms by which cigarette smoking impairs fracture healing are not fully understood. There are few studies reporting the effects of cigarette smoking on new blood vessel formation during the early stage of fracture healing. We tested the hypothesis that cigarette smoke inhalation may suppress angiogenesis and delay fracture healing. Methods: We established a custom-made chamber with airflow for rats to inhale cigarette smoke continuously, and tested our hypothesis using a femoral osteotomy model, radiograph and microCT imaging, and various biomechanical and biological tests. Results: In the smoking group, Western blot analysis and immunohistochemical staining revealed less expression of vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF). The smoking group also had a lower microvessel density than the control group. Image and biochemical analysis also demonstrated delayed bone healing. Conclusion: Cigarette smoke inhalation was associated with decreased expression of angiogenic markers in the early bone healing phase and with impaired bone healing. Cite this article: Bone Joint Res. 2020;9(3):99–107.
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Cigarette smoke inhalation results in decreased expression of angiogenic markers VEGF and von Willebrand factor during the early phase of bone healing, with a consequent decrease in the density of newly formed microvessels.
“The authors observed that cigarette smoke inhalation results in decreased expression of angiogenic markers, such as vascular endothelial growth factor (VEGF) and von Willebrand factor (vWF), during the early phase of bone healing, with a consequent decrease in the density of newly formed microvessels.”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [58]
Smoke inhalation decreases the expression of angiogenic markers, compromises bone healing, and may delay fracture union.
“For example, it has been reported that smoke inhalation causes a decrease in the expression of angiogenic markers and compromises bone healing, as well as possibly leading to a delay in fracture union [58].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [58]
Smoking may impair fracture healing by altering fracture hematoma formation.
“Their findings suggest that smoking may impair healing by altering fracture hematoma formation [58].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [58]
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Metadata
- Authors
- Chang, C.-J., Jou, I.-M., Wu, T.-T., Su, F.-C., & Tai, T.-W.
- Affiliations
- National Cheng Kung University Hospital (TW)
- E-Da Hospital (TW)
- National Cheng Kung University (TW)
- Corresponding author
- Tai, Ta-Wei
- Venue
- Bone & Joint Research
- Published
- 2020-03
- Volume
- 9
- Issue
- 3
- Pages
- 99-107
- ISSN
- 2046-3758 (ISSN-L)
- PMC
- PMC7229299
- OpenAlex
- W3010553211
- Cited by
- 67
- References
- 60
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 11 · 2023: 13 · 2022: 9 · 2021: 10
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- online.boneandjoint.org.uk/TDM (tdm)
- Locations
- Bone and Joint Research (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- cigarette smoking, cigarette smoke inhalation, angiogenesis, fracture healing, bone regeneration, vascular endothelial growth factor, von Willebrand factor, microvessel density, femoral osteotomy
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