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Cited by 912

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition

Reaven, Gerald M.·1993·Annual Review of Medicine
DOI 10.1146/annurev.me.44.020193.001005
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Abstract

Resistance to insulin-mediated glucose uptake is characteristic of individuals with impaired glucose intolerance or non-insulin-dependent diabetes, and it also occurs commonliyn patients with high blood pressure. The physiological response to a decrease in insulin-mediated glucose uptake is an increase in insulin secretion, and as long as a state of compensatory hyperinsulinemia can be maintained, frank decompensation of glucose tolerance can be prevented. However, it is likely that the defect in insulin action and/or the associated hyperinsulinemia will lead to an increase in plasma triglyceride and a decrease in high density lipoprotein-cholesterol concentration, and high blood pressure. It seems likely that the cluster of changes associated with resistance to insulin-mediated glucose uptake comprise a syndrome, which plays an important role in the etiology and clinical course of patients with non-insulin-dependent diabetes, high blood pressure, and coronary heart disease.

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Metadata

Authors
Reaven, G. M.
Venue
Annual Review of Medicine
Publisher
Annual Reviews
Published
1993-02
Volume
44
Issue
1
Pages
121-131
ISSN
  • 0066-4219 (ISSN-L)
  • 1545-326X
DOI
10.1146/annurev.me.44.020193.001005
OpenAlex
W2172692903
Cited by
912
References
4
FWCI
11.50
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.