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Role of Insulin Resistance in Human Disease (Syndrome X): An Expanded Definition
Abstract
Resistance to insulin-mediated glucose uptake is characteristic of individuals with impaired glucose intolerance or non-insulin-dependent diabetes, and it also occurs commonliyn patients with high blood pressure. The physiological response to a decrease in insulin-mediated glucose uptake is an increase in insulin secretion, and as long as a state of compensatory hyperinsulinemia can be maintained, frank decompensation of glucose tolerance can be prevented. However, it is likely that the defect in insulin action and/or the associated hyperinsulinemia will lead to an increase in plasma triglyceride and a decrease in high density lipoprotein-cholesterol concentration, and high blood pressure. It seems likely that the cluster of changes associated with resistance to insulin-mediated glucose uptake comprise a syndrome, which plays an important role in the etiology and clinical course of patients with non-insulin-dependent diabetes, high blood pressure, and coronary heart disease.
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Metadata
- Authors
- Reaven, G. M.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1993-02
- Volume
- 44
- Issue
- 1
- Pages
- 121-131
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2172692903
- Cited by
- 912
- References
- 4
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
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