The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Preeclampsia and Angiogenic Imbalance
Abstract
Preeclampsia is a systemic syndrome of pregnancy that originates in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of preeclampsia was largely unknown, but recent work suggests a key role for altered expression of placental antiangiogenic factors. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal circulation weeks before the onset of preeclampsia. These antiangiogenic factors produce systemic endothelial dysfunction, resulting in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, and the role of angiogenic proteins in early placental vascular development is just beginning to be explored. These discoveries have exciting clinical implications and are likely to transform the detection and treatment of preeclampsia in the future.
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Cites
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Self-citationCirculating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Self-citationA Reversible Posterior Leukoencephalopathy Syndrome
Hinchey, J., Chaves, C., Appignani, B., Breen, J., Pao, L., Wang, A., Pessin, M. S., Lamy, C., Mas, J.-L., & Caplan, L. R. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602223340803 · Cited by 3,340
Circulating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics & Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,615
Latest Advances in Understanding Preeclampsia
Redman, C. W., & Sargent, I. L. (2005) · Science · doi:10.1126/science.1111726 · Cited by 2,607
Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859
Soluble endoglin contributes to the pathogenesis of preeclampsia
Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855
Self-citationSoluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia
Levine, R. J., Lam, C., Qian, C., Yu, K. F., Maynard, S. E., Sachs, B. P., Sibai, B. M., Epstein, F. H., Romero, R., Thadhani, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055352 · Cited by 1,802
Self-citationRisk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
Duckitt, K., & Harrington, D. (2005) · BMJ · doi:10.1136/bmj.38380.674340.e0 · Cited by 1,784
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Hanna, J., Goldman-Wohl, D., Hamani, Y., Avraham, I., Greenfield, C., Natanson-Yaron, S., Prus, D., Cohen-Daniel, L., Arnon, T. I., Manaster, I., et al. (2006) · Nature Medicine · doi:10.1038/nm1452 · Cited by 1,681
Cited by
Why is placentation abnormal in preeclampsia?
Fisher, S. J. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.042 · Cited by 630
Shah, D. A., & Khalil, R. A. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.04.012 · Cited by 422
Vascular biology of preeclampsia
Myatt, L., & Webster, R. P. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03259.x · Cited by 292
Weel, I. C., Baergen, R. N., Romão-Veiga, M., Borges, V. T., Ribeiro, V. R., Witkin, S. S., Bannwart-Castro, C., Peraçoli, J. C., De Oliveira, L., & Peraçoli, M. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157584 · Cited by 131
Expert review: preeclampsia Type I and Type II.
Yagel, S., Cohen, S. M., Admati, I., Skarbianskis, N., Solt, I., Zeisel, A., Beharier, O., & Goldman-Wohl, D. (2023) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2023.101203 · Cited by 61
Metadata
- Authors
- Maynard, S., Epstein, F. H., & Karumanchi, S. A.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2008-02-01
- Volume
- 59
- Issue
- 1
- Pages
- 61-78
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2142551707
- Cited by
- 332
- References
- 101
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maynard, S., Epstein, F. H., & Karumanchi, S. A. (2008). Preeclampsia and Angiogenic Imbalance. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.59.110106.214058
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
