Cited by 458Antimicrobial Resistance in StaphylococcusStreptococcal Infections and TreatmentsBacterial biofilms and quorum sensing

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Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus

Otto, Michael·2010·Annual Review of Microbiology

DOI 10.1146/annurev.micro.112408.134309

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Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains are causing a severe pandemic of mainly skin and soft tissue and occasionally fatal infections. The basis of their success is the combination of methicillin resistance at low fitness cost and high virulence. Investigation of the virulence potential of CA-MRSA, a key prerequisite for the development of anti-CA-MRSA therapeutics, has focused on strain USA300, which is responsible for the most serious CA-MRSA epidemic seen in the United States. Current data indicate that in this strain virulence evolved via increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-soluble modulins, and acquisition of the phage-encoded Panton-Valentine leukocidin (PVL) genes. All these toxins impact disease progression in animal models of USA300 infection. In contrast, the basis of virulence in other CA-MRSA epidemics, which also include PVL-negative strains, is poorly understood.

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Authors: Otto, M.
Affiliations: National Institutes of Health (US)
Corresponding author: Otto, Michael
ORCID: Otto, Michael
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2010-10-13
Volume: 64
Issue: 1
Pages: 143-162
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev.micro.112408.134309
OpenAlex: W2138666908
Cited by: 457
References: 136
Citations by year: 2026: 9 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 24 · 2020: 23 · 2019: 25 · 2018: 30 · 2017: 19 · 2016: 35 · 2015: 33 · 2014: 57 · 2013: 71 · 2012: 47
FWCI: 5.59
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: community-associated methicillin-resistant Staphylococcus aureus, virulence factors, USA300, alpha-toxin, phenol-soluble modulins, Panton-Valentine leukocidin, skin and soft tissue infections, virulence evolution, animal models of infection
MeSH terms: Animals, Bacterial Proteins, Bacterial Toxins, Disease Models, Animal, Exotoxins, Hemolysin Proteins, Humans, Leukocidins, Staphylococcal Skin Infections, United States, Virulence, Bacteremia, Community-Acquired Infections, Soft Tissue Infections, Virulence Factors, Methicillin-Resistant Staphylococcus aureus

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Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus

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