The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Abstract
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains are causing a severe pandemic of mainly skin and soft tissue and occasionally fatal infections. The basis of their success is the combination of methicillin resistance at low fitness cost and high virulence. Investigation of the virulence potential of CA-MRSA, a key prerequisite for the development of anti-CA-MRSA therapeutics, has focused on strain USA300, which is responsible for the most serious CA-MRSA epidemic seen in the United States. Current data indicate that in this strain virulence evolved via increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-soluble modulins, and acquisition of the phage-encoded Panton-Valentine leukocidin (PVL) genes. All these toxins impact disease progression in animal models of USA300 infection. In contrast, the basis of virulence in other CA-MRSA epidemics, which also include PVL-negative strains, is poorly understood.
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“These virulence factors include Panton-Valentine leukocidin (pvl), staphylococcal protein A (spa) and α-hemolysin (hla) [24].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [24]
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Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,762
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Metadata
- Authors
- Otto, M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Otto, Michael
- ORCID
- Otto, Michael
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2010-10-13
- Volume
- 64
- Issue
- 1
- Pages
- 143-162
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2138666908
- Cited by
- 457
- References
- 136
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 24 · 2020: 23 · 2019: 25 · 2018: 30 · 2017: 19 · 2016: 35 · 2015: 33 · 2014: 57 · 2013: 71 · 2012: 47
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- community-associated methicillin-resistant Staphylococcus aureus, virulence factors, USA300, alpha-toxin, phenol-soluble modulins, Panton-Valentine leukocidin, skin and soft tissue infections, virulence evolution, animal models of infection
- MeSH terms
- Animals, Bacterial Proteins, Bacterial Toxins, Disease Models, Animal, Exotoxins, Hemolysin Proteins, Humans, Leukocidins, Staphylococcal Skin Infections, United States, Virulence, Bacteremia, Community-Acquired Infections, Soft Tissue Infections, Virulence Factors, Methicillin-Resistant Staphylococcus aureus
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