Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

The Disease Burden Associated With Overweight and Obesity

Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works

Fatty acid synthase, a proficient multifunctional enzyme

Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 820 · see citing works

Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.

McGarry, J., Leatherman, G. F., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34693-8 · Cited by 591 · see citing works

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

Yang, X.-J., Kow, L., Funabashi, T., & Mobbs, C. V. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1763 · Cited by 277 · see citing works

Structure of the Complex between the Antibiotic Cerulenin and Its Target, β-Ketoacyl-Acyl Carrier Protein Synthase

Moche, M., Schneider, G., Edwards, P. C., Dehesh, K., & Lindqvist, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6031 · Cited by 200 · see citing works

In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis.

McGarry, J., & Foster, D. W. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86870-9 · Cited by 191 · see citing works

Control of food intake by fatty acid oxidation and ketogenesis

Scharrer, E. (1999) · Nutrition · doi:10.1016/s0899-9007(99)00125-2 · Cited by 157 · see citing works

Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells 1

Kusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., & Suzuki, T. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800505 · Cited by 157 · see citing works

Neuropeptide Y Induced Feeding in the Rat Is Mediated by a Novel Receptor

O'Shea, D. B., Morgan, D. G. A., Meeran, K. M., Edwards, C. M. B., Turton, M. D., Choi, S. J., Heath, M., Gunn, I., Taylor, G. M., Howard, J. K., et al. (1997) · Endocrinology · doi:10.1210/endo.138.1.4899 · Cited by 144 · see citing works

Effect of Fasting and Leptin Deficiency on Hypothalamic Neuropeptide Y Gene Transcription in Vivo Revealed by Expression of a lacZ Reporter Gene

Schwartz, M. W., Erickson, J. C., Baskin, D. G., & Palmiter, R. D. (1998) · Endocrinology · doi:10.1210/endo.139.5.6000 · Cited by 83 · see citing works

Inhibition of fatty acid synthesis in isolated adipocytes by 5‐(tetradecyloxy)‐2‐furoic acid

Halvorson, D. L., & McCune, S. A. (1984) · Lipids · doi:10.1007/bf02534514 · Cited by 62 · see citing works

An adipocyte-central nervous system regulatory loop in the control of adipose homeostasis

Loftus, T. M. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0274 · Cited by 40 · see citing works

On the Mode of Action of Lipid-lowering Agents

Maragoudakis, M. E., Hankin, H., & Wasvary, J. M. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45709-8 · Cited by 28 · see citing works

Effect of Glucose and 2-Deoxyglucose on Hypothalamic GABA Release in Lactating Rats

Grossman, B. M., Devore, M. L., Kelso, E. W., et al. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00368-x · Cited by 10 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123 · see citing works

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903 · see citing works

Lipotoxic diseases

Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654 · see citing works

Hypothalamic KATP channels control hepatic glucose production

Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

Obici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works

Hypothalamic sensing of fatty acids

Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works

Bacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery

Campbell, J. W., & Cronan, J. E. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.305 · Cited by 479 · see citing works

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works

A brain-liver circuit regulates glucose homeostasis

Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385 · see citing works

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works

Obesity‐related leptin regulates Alzheimer's Aβ

Fewlass, D. C., Noboa, K., Pi‐Sunyer, F. X., Johnston, J. M., Yan, S. D., & Tezapsidis, N. (2004) · The FASEB Journal · doi:10.1096/fj.04-2572com · Cited by 308 · see citing works

Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

Ruderman, N. B., Saha, A. K., & Kraegen, E. W. (2003) · Endocrinology · doi:10.1210/en.2003-0849 · Cited by 266 · see citing works

Obesity and dyslipidemia

Franssen, R., Monajemi, H., Stroes, E. S. G., & Kastelein, J. J. P. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.003 · Cited by 270 · see citing works

Glucose-sensing neurons

Routh, V. H. (2002) · Physiology &amp; Behavior · doi:10.1016/s0031-9384(02)00761-8 · Cited by 237 · see citing works

Molecular disruption of hypothalamic nutrient sensing induces obesity

He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708385104 · Cited by 215 · see citing works

Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211 · see citing works

Neurotrophic factor control of satiety and body weight

Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203 · see citing works

The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation

Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178 · see citing works

Lipids in Psychiatric Disorders and Preventive Medicine

Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works

Regulation of hypothalamic malonyl-CoA by central glucose and leptin

Wolfgang, M. J., Cha, S. H., Sidhaye, A., Chohnan, S., Cline, G., Shulman, G. I., & Lane, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709778104 · Cited by 127 · see citing works

Lipoprotein Lipase in the Brain and Nervous System

Wang, H., & Eckel, R. H. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150703 · Cited by 105 · see citing works

Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis

Conti, R., Mannucci, E., Pessotto, P., Tassoni, E., Carminati, P., Giannessi, F., & Arduini, A. (2011) · Diabetes · doi:10.2337/db10-0346 · Cited by 98 · see citing works

GLP-1/GLP-1R signaling in regulation of adipocyte differentiation and lipogenesis

Chen, J., Zhao, H., Ma, X., Zhang, Y., Lu, S., Wang, Y., Zong, C., Qin, D., Wang, Y., Yingfeng Yang, Y., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000478872 · Cited by 94 · see citing works

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

Axelrod, C. L., King, W. T., Davuluri, G., Noland, R. C., Hall, J., Hull, M., Dantas, W. S., Zunica, E. R., Alexopoulos, S. J., Hoehn, K. L., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012088 · Cited by 89 · see citing works

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86 · see citing works

M<scp>ETABOLIC</scp> L<scp>ESSONS FROM</scp> G<scp>ENETICALLY</scp> L<scp>EAN</scp> M<scp>ICE</scp>

Reitman, M. L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102849 · Cited by 75 · see citing works

Thermogenic and metabolic antiobesity drugs: rationale and opportunities

Clapham, J. C., & Arch, J. R. S. (2007) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00608.x · Cited by 60 · see citing works

Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12

Sakurai, N., Miki, Y., Suzuki, T., Watanabe, K., Narita, T., Ando, K., Yung, T. M. C., Aoki, D., Sasano, H., & Handa, H. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.01.010 · Cited by 60 · see citing works

Novel Effect of C75 on Carnitine Palmitoyltransferase I Activity and Palmitate Oxidation

Bentebibel, A., Sebastián, D., Herrero, L., López-Viñas, E., Serra, D., Asins, G., Gómez-Puertas, P., & Hegardt, F. G. (2006) · Biochemistry · doi:10.1021/bi052186q · Cited by 58 · see citing works

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

Mera, P., Bentebibel, A., López-Viñas, E., Cordente, A. G., Gurunathan, C., Sebastián, D., Vázquez, I., Herrero, L., Ariza, X., Gómez-Puertas, P., et al. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.020 · Cited by 57 · see citing works

Estradiol‐Induced Anorexia Is Independent of Leptin and Melanin‐Concentrating Hormone

Tritos, N. A., Segal‐Lieberman, G., Vezeridis, P. S., & Maratos‐Flier, E. (2004) · Obesity Research · doi:10.1038/oby.2004.84 · Cited by 47 · see citing works

Molecular Targets for Obesity Therapy in the Brain

Obici, S. (2009) · Endocrinology · doi:10.1210/en.2009-0409 · Cited by 45 · see citing works

Central Control of Glucose Homeostasis

Puglianiello, A., & Cianfarani, S. (2006) · The Review of Diabetic Studies · doi:10.1900/rds.2006.3.54 · Cited by 14 · see citing works

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Wu, M. S., Singh, S. B., Wang, J., Chung, C. C., Salituro, G., Karanam, B. V., Lee, S. H., Powles, M., Ellsworth, K. P., Lassman, M. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002588108 · Cited by 147 · see citing works

Synthesis and antitumor activity of an inhibitor of fatty acid synthase

Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., & Townsend, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3450 · Cited by 568 · see citing works

The Synthetic Triterpenoid CDDO-Im Inhibits Fatty Acid Synthase Expression and Has Antiproliferative and Proapoptotic Effects in Human Liposarcoma Cells

Hughes, D. T., Martel, P. M., Kinlaw, W. B., & Eisenberg, B. L. (2008) · Cancer Investigation · doi:10.1080/07357900701522612 · Cited by 18 · see citing works

Mass Spectrometry-Based Systems Approach for Identification of Inhibitors ofPlasmodium falciparumFatty Acid Synthase

Sharma, S., Sharma, S. K., Modak, R., et al. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00124-07 · Cited by 27 · see citing works

Xenograft Studies of Fatty Acid Synthesis Inhibition as Novel Therapy for Breast Cancer

Kuhajda, F. P. (2000) · Defense Technical Information Center (DTIC)