Function of Pseudomonas Porins in Uptake and Efflux

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S., Warrener, P., Hickey, M. J., Brinkman, F. S. L., HUFNAGLE, W. O., Kowalik, D., Mj, L., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,544 · see citing works

Structure and function of bacterial outer membrane proteins: barrels in a nutshell

Koebnik, R., Locher, K. P., & Gelder, P. V. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01983.x · Cited by 1,206 · see citing works

Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa

Li, X. Z., Nikaido, H., & Poole, K. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.1948 · Cited by 646 · see citing works

Structural Basis for Sugar Translocation Through Maltoporin Channels at 3.1 Å Resolution

Schirmer, T., Keller, T. A., Wang, Y.-F., & Rosenbusch, J. P. (1995) · Science · doi:10.1126/science.7824948 · Cited by 593 · see citing works

Characterization of MexE–MexF–OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa

Köhler, T., Michéa-Hamzehpour, M., Henze, U. U., Gotoh, N., Curty, L. K., & Péchère, J.-C. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2281594.x · Cited by 549 · see citing works

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment

Hancock, R. E. W., & Speert, D. P. (2000) · Drug Resistance Updates · doi:10.1054/drup.2000.0152 · Cited by 518 · see citing works

Multidrug resistance mechanisms: drug efflux across two membranes

Zgurskaya, H. I., & Nikaido, H. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01926.x · Cited by 466 · see citing works

The bacterial outer membrane as a drug barrier

HANCOCK, R. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)81773-8 · Cited by 391 · see citing works

Involvement of an Active Efflux System in the Natural Resistance of Pseudomonas aeruginosa to Aminoglycosides

Aires, J., Köhler, T., Nikaido, H., & Plésiat, P. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.11.2624 · Cited by 390 · see citing works

The response of Pseudomonas aeruginosa to iron: genetics, biochemistry and virulence

Vasil, M. L., & Ochsner, U. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01586.x · Cited by 367 · see citing works

Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa The GenBank accession numbers for the sequences reported in this paper are AF055999, AF127222, and AF127223.

Ochsner, U. A., Johnson, Z., & Vasil, M. L. (2000) · Microbiology · doi:10.1099/00221287-146-1-185 · Cited by 310 · see citing works

Multiple pathways allow protein secretion across the bacterial outer membrane

Thanassi, D. G., & Hultgren, S. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00111-3 · Cited by 296 · see citing works

Multidrug resistance in Gram-negative bacteria

Poole, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00242-3 · Cited by 277 · see citing works

Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway

Yahr, T. L., Goranson, J., & Frank, D. W. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.01554.x · Cited by 275 · see citing works

PhoP–PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer‐membrane protein OprH and polymyxin B resistance

Macfarlane, E. L. A., Kwasnicka, A., Ochs, M. M., & Hancock, R. E. W. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01600.x · Cited by 256 · see citing works

Characterization of a Pseudomonas aeruginosa Efflux Pump Contributing to Aminoglycoside Impermeability

Westbrock-Wadman, S., Sherman, D. R., Hickey, M. J., Coulter, S. N., Zhu, Y. Q., Warrener, P., Nguyen, L. Y., Shawar, R. M., Folger, K. R., & Stover, C. K. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2975 · Cited by 242 · see citing works

Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids

Ochs, M. M., McCusker, M. P., Bains, M., & Hancock, R. E. W. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1085 · Cited by 216 · see citing works

Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides.

Trias, J., & Nikaido, H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55452-1 · Cited by 212 · see citing works

Identification and characterization of porins in Pseudomonas aeruginosa.

Nikaido, H., Nikaido, K., & Harayama, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35239-0 · Cited by 191 · see citing works

FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa: a phenolate siderophore receptor homologous to hydroxamate siderophore receptors

Ankenbauer, R. G., & Quan, H. N. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.307-319.1994 · Cited by 141 · see citing works

Pseudomonas aeruginosa Reveals High Intrinsic Resistance to Penem Antibiotics: Penem Resistance Mechanisms and Their Interplay

Okamoto, K., Gotoh, N., & Nishino, T. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.7.1964-1971.2001 · Cited by 137 · see citing works

Protein secretion in Pseudomonas aeruginosa

Tommassen, J. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90336-m · Cited by 134 · see citing works

Structure of TolC, the outer membrane component of the bacterial type I efflux system, derived from two‐dimensional crystals

Koronakis, V. E., Li, J., Koronakis, E., et al. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.d01-1880.x · Cited by 127 · see citing works

The OprB porin plays a central role in carbohydrate uptake in Pseudomonas aeruginosa

Wylie, J., & Worobec, E. A. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.11.3021-3026.1995 · Cited by 119 · see citing works

Iron‐free pyoverdin binds to its outer membrane receptor FpvA in Pseudomonas aeruginosa: a new mechanism for membrane iron transport

Schalk, I. J., Hennard, C., Dugave, C., Poole, K., Abdallah, M. A., & Pattus, F. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02207.x · Cited by 113 · see citing works

Cloning and characterization of the ferric enterobactin receptor gene (pfeA) of Pseudomonas aeruginosa

Dean, C. R., & Poole, K. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.2.317-324.1993 · Cited by 112 · see citing works

Protein secretion inPseudomonas aeruginosa

Tommassen, J., Filloux, A., Bally, M., et al. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05824.x · Cited by 112 · see citing works

Secondary structure of the outer membrane proteins OmpA of Escherichia coli and OprF of Pseudomonas aeruginosa

Sugawara, E., Steiert, M., Rouhani, S., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.20.6067-6069.1996 · Cited by 111 · see citing works

Reevaluation, using intact cells, of the exclusion limit and role of porin OprF in Pseudomonas aeruginosa outer membrane permeability

Bellido, F., Martin, N., Siehnel, R., & Hancock, R. E. W. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.16.5196-5203.1992 · Cited by 107 · see citing works

Identification and characterization of the pupB gene encoding an inducible ferric‐pseudobactin receptor of Pseudomonas putida WCS358

Koster, M. C., van de Vossenberg, J. L. C. M., Leong, J., & Weisbeek, P. J. (1993) · Molecular Microbiology · doi:10.1111/j.1365-2958.1993.tb01603.x · Cited by 101 · see citing works

Roles of the Carboxy-Terminal Half of Pseudomonas aeruginosa Major Outer Membrane Protein OprF in Cell Shape, Growth in Low-Osmolarity Medium, and Peptidoglycan Association

Rawling, E. G., Brinkman, F. S. L., & Hancock, R. E. W. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.14.3556-3562.1998 · Cited by 98 · see citing works

TolC of Escherichia coli Functions as an Outer Membrane Channel

Benz, R., Maier, E., & Gentschev, I. (1993) · Zentralblatt für Bakteriologie · doi:10.1016/s0934-8840(11)80836-4 · Cited by 96 · see citing works

The C-terminal domain of the Pseudomonas secretin XcpQ forms oligomeric rings with pore activity

Brok, R. G. P. M., Gelder, P. V., Winterhalter, M., Ziese, U., Koster, A. J., de Cock, H., Koster, M. C., Tommassen, J., & Bitter, W. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3340 · Cited by 95 · see citing works

Genetic definition of the substrate selectivity of outer membrane porin protein OprD of Pseudomonas aeruginosa

Huang, H., & Hancock, R. E. W. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.24.7793-7800.1993 · Cited by 95 · see citing works

Emergence of resistance to imipenem in Pseudomonas aeruginosa

Lynch, M. J., Drusano, G. L., & Mobley, H. L. T. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.12.1892 · Cited by 94 · see citing works

Mechanisms of solute transport through outer membrane porins: burning down the house

Klebba, P. E., & Newton, S. M. C. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80017-9 · Cited by 88 · see citing works

The role of specific surface loop regions in determining the function of the imipenem-specific pore protein OprD of Pseudomonas aeruginosa

Huang, H., & Hancock, R. E. W. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.11.3085-3090.1996 · Cited by 88 · see citing works

Sequence Changes in the Ton Box Region of BtuB Affect Its Transport Activities and Interaction with TonB Protein

Cadieux, N., Bradbeer, C., & Kadner, R. J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.21.5954-5961.2000 · Cited by 85 · see citing works

Outer Membrane Permeability of Pseudomonas aeruginosa

Nikaido, H., & HANCOCK, R. E. W. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-307210-8.50009-9 · Cited by 84 · see citing works

Resistance to β-Lactam Antibiotics in Pseudomonas aeruginosa Due to Interplay between the MexAB-OprM Efflux Pump and β-Lactamase

Nakae, T., Nakajima, A., Ono, T., et al. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1301 · Cited by 82 · see citing works

Protein C (OprC) of the outer membrane of Pseudomonas aeruginosa is a copper-regulated channel protein

Hiroshi Yoneyama, C., & Nakae, T. (1996) · Microbiology · doi:10.1099/13500872-142-8-2137 · Cited by 79 · see citing works

Influence of a Putative ECF Sigma Factor on Expression of the Major Outer Membrane Protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens

Brinkman, F. S. L., Schoofs, G., Hancock, R. E. W., et al. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.16.4746-4754.1999 · Cited by 77 · see citing works

Membrane topology and site‐specific mutagenesis of Pseudomonas aeruginosa porin OprD

Huang, H., Jeanteur, D., Pattus, F., & Hancock, R. E. W. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02319.x · Cited by 65 · see citing works

The Amino Terminus of Pseudomonas aeruginosa Outer Membrane Protein OprF Forms Channels in Lipid Bilayer Membranes: Correlation with a Three-Dimensional Model

Brinkman, F. S. L., Bains, M., & Hancock, R. E. W. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.18.5251-5255.2000 · Cited by 64 · see citing works

Chimeric animal and plant viruses expressing epitopes of outer membrane protein F as a combined vaccine againstPseudomonas aeruginosalung infection

Gilleland, H. E., Gilleland, L. B., Staczek, J., et al. (2000) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2000.tb01442.x · Cited by 62 · see citing works

Amino Acid-Mediated Induction of the Basic Amino Acid-Specific Outer Membrane Porin OprD from Pseudomonas aeruginosa

Ochs, M. M., Lu, C., Hancock, R. E. W., & Abdelal, A. T. H. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.17.5426-5432.1999 · Cited by 61 · see citing works

Role of Putative Loops 2 and 3 in Imipenem Passage through the Specific Porin OprD of Pseudomonas aeruginosa

Ochs, M. M., Bains, M., & Hancock, R. E. W. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1983-1985.2000 · Cited by 61 · see citing works

Evaluation of a Structural Model of Pseudomonas aeruginosa Outer Membrane Protein OprM, an Efflux Component Involved in Intrinsic Antibiotic Resistance

Wong, K. K. Y., Brinkman, F. S. L., Benz, R., & Hancock, R. E. W. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.1.367-374.2001 · Cited by 59 · see citing works

Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers

Larbig, M., Mansouri, E., Freihorst, J., et al. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00550-8 · Cited by 56 · see citing works

Mutational Analysis of the OprM Outer Membrane Component of the MexA-MexB-OprM Multidrug Efflux System of Pseudomonas aeruginosa

Li, X.-Z., & Poole, K. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.1.12-27.2001 · Cited by 53 · see citing works

Specificity of the glucose channel formed by protein D1 of Pseudomonas aeruginosa

Trias, J., Rosenberg, E. Y., & Nikaido, H. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90148-4 · Cited by 49 · see citing works

Identification of an additional member of the secretin superfamily of proteins in Pseudomonas aeruginosa that is able to function in type II protein secretion

Martínez, A., Ostrovsky, P., & Nunn, D. N. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00888.x · Cited by 44 · see citing works

Outer Membrane Proteins

Hancock, R. E. W., & Worobec, E. A. (1998) · Springer eBooks · doi:10.1007/978-1-4899-0120-0_5 · Cited by 42 · see citing works

Properties of a Pseudomonas stutzeri outer membrane channel-forming protein (NosA) required for production of copper-containing N2O reductase

Lee, H. S., Hancock, R. E. W., & Ingraham, J. L. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.4.2096-2100.1989 · Cited by 40 · see citing works

Ion channel formation by N-terminal domain: a common feature of OprFs ofPseudomonasand OmpA ofEscherichia coli

Saint, N., Hamel, C. E., Dé, E., et al. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09296.x · Cited by 40 · see citing works

Role of Porins in the Antibiotic Susceptibility of Pseudomonas aeruginosa: Construction of Mutants with Deletions in the Multiple Porin Genes

Hiroshi Yoneyama, C., Yamano, Y., & Nakae, T. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2102 · Cited by 36 · see citing works

The pyoverdin receptor FpvA, a TonB-dependent receptor involved in iron uptake byPseudomonas aeruginosa(Review)

Schalk, I. J. (2000) · Molecular Membrane Biology · doi:10.1080/09687680050197356 · Cited by 34 · see citing works

Membrane topology of the outer membrane protein OprH from Pseudomonas aeruginosa: PCR-mediated site-directed insertion and deletion mutagenesis

Rehm, B. H. A., & Hancock, R. E. W. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.11.3346-3349.1996 · Cited by 29 · see citing works

Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49

Pumbwe, L., Everett, M. J., Hancock, R. E. W., & Piddock, L. J. V. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08456.x · Cited by 23 · see citing works

In vivo and in vitro studies of major surface loop deletion mutants of the Escherichia coli K‐12 maltoporin: contribution to maltose and maltooligosaccharide transport and binding

Andersen, C., Bachmeyer, C., Täuber, H., et al. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01406.x · Cited by 21 · see citing works

The Role of Specific Lysine Residues in the Passage of Anions through the Pseudomonas aeruginosa Porin OprP

Sukhan, A., & Hancock, R. E. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21239 · Cited by 19 · see citing works

Involvement of the C-terminal part of Pseudomonas fluorescens OprF in the modulation of its pore-forming properties

Hamel, C. E., Freulet-Marrière, M.-A., Jaquinod, M., Dé, E., Molle, G., & Orange, N. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00300-x · Cited by 12 · see citing works

Localization of functional domains in the Escherichia coli coprogen receptor FhuE and the Pseudomonas putida ferric-pseudobactin 358 receptor PupA

Bitter, W., van Leeuwen, I. S., de Boer, J., et al. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00297276 · Cited by 9 · see citing works

Chimeric animal and plant viruses expressing epitopes of outer membrane protein F as a combined vaccine against Pseudomonas aeruginosa lung infection

Gilleland, H. E. (2000) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(99)00206-0 · Cited by 8 · see citing works

Pseudomonas

Montie, T. C. (1998) · Springer eBooks · doi:10.1007/978-1-4899-0120-0 · Cited by 7 · see citing works

Ion channel formation by N-terminal domain: a common feature of OprFs of Pseudomonas and OmpA of Escherichia coli

Saint, N. (2000) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(00)00345-1 · Cited by 3 · see citing works

Molecular Basis of Bacterial Outer Membrane Permeability Revisited

Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316 · see citing works

Mechanisms of Antibiotic Resistance

Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782 · see citing works

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

Pagès, J.-M., James, C. E., & Winterhalter, M. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1994 · Cited by 939 · see citing works

Mechanisms of antibiotic resistance

Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421 · see citing works

Interspecies competition triggers virulence and mutability in <i>Candida albicans</i> – <i>Pseudomonas aeruginosa</i> mixed biofilms

Trejo-Hernández, A., Andrade-Domínguez, A., Hernández, M., & Encarnación, S. (2014) · The ISME Journal · doi:10.1038/ismej.2014.53 · Cited by 135 · see citing works

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

Verdial, C., Serrano, I., Tavares, L., Gil, S., & Oliveira, M. (2023) · Biomedicines · doi:10.3390/biomedicines11041221 · Cited by 71 · see citing works

Bacterial outer membrane channel for divalent metal ion acquisition

Hohle, T. H., Franck, W. L., Stacey, G., & O'Brian, M. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110137108 · Cited by 66 · see citing works

Kin selection for cooperation in natural bacterial populations

Belcher, L. J., Dewar, A. E., Ghoul, M., & West, S. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119070119 · Cited by 36 · see citing works

Research progress on mechanism of Pseudomonas aeruginosa efflux pumps and development of potential efflux inhibitors

Zhang, H., Xu, X., Sheng, A., et al. (2014) · Chinese Journal of Asthma · doi:10.3760/cma.j.issn.1673-436x.2014.02.006

The Research of Active Efflux System MexAB-OprM of Pseudomonas Aeruginosa

Yon, D. (2009) · Medical Recapitulate

A Major Outer-membrane Protein Functions as a Porin in Haemophilus Influenzae

Burns, J. L., & Smith, A. L. (1987) · Microbiology · doi:10.1099/00221287-133-5-1273 · Cited by 34 · see citing works

Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa

Hirakata, Y., Kondo, A., Hoshino, K., et al. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.06.007 · Cited by 77 · see citing works

Direct in Situ Structural Analysis of Recombinant Outer Membrane Porins Expressed in an OmpA-Deficient Mutant Escherichia coli Strain

Hoenger, A., Ghosh, R., Schoenenberger, C., et al. (1993) · Journal of Structural Biology · doi:10.1006/jsbi.1993.1051 · Cited by 18 · see citing works