Cited by 71Bacterial biofilms and quorum sensingAntimicrobial agents and applicationsInfection Control in Healthcare

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

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Verdial, Cláudia, Serrano, Isa, Tavares, Luís, Gil, Solange, Oliveira, Manuela·2023·Biomedicines

Abstract

Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple hospital- and community-acquired infections, both in human and veterinary medicine. P. aeruginosa persistence in clinical settings is worrisome and is a result of its remarkable flexibility and adaptability. This species exhibits several characteristics that allow it to thrive under different environmental conditions, including the ability to colonize inert materials such as medical equipment and hospital surfaces. P. aeruginosa presents several intrinsic mechanisms of defense that allow it to survive external aggressions, but it is also able to develop strategies and evolve into multiple phenotypes to persevere, which include antimicrobial-tolerant strains, persister cells, and biofilms. Currently, these emergent pathogenic strains are a worldwide problem and a major concern. Biocides are frequently used as a complementary/combination strategy to control the dissemination of P. aeruginosa-resistant strains; however, tolerance to commonly used biocides has also already been reported, representing an impediment to the effective elimination of this important pathogen from clinical settings. This review focuses on the characteristics of P. aeruginosa responsible for its persistence in hospital environments, including those associated with its antibiotic and biocide resistance ability.

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Crossref · 10.3390/biomedicines11041221

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  • Pseudomonas spp. typically take advantage of weakened immune systems and cause infections that can be acquired in hospitals or the community, affecting both humans and animals.

    “Pseudomonas spp., on the other hand, typically take advantage of weakened immune systems and causes infections that can be acquired in hospitals or the community, affecting both humans and animals [73].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [73]

    The Abstract describes P. aeruginosa as an opportunistic pathogen causing hospital- and community-acquired infections in human and veterinary medicine. The Introduction also associates it with illness especially in immunocompromised individuals. The source discusses P. aeruginosa specifically, so it does not establish the claim for Pseudomonas species generally. (LLM, conf=0.86)

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3 of the 208 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

  1. [10]Sousa A. Avaliação In Vitro de Estratégicas Antimicrobianas Inovadoras Para Controlo de Otites Externas Por Pseudomonas Aeruginosa No Cão Master’s Thesis Faculdade de Medicina Veterinária-Universidade de Lisboa Lisbon, Portugal 2021
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Authors
Verdial, C., Serrano, I., Tavares, L., Gil, S., & Oliveira, M.
Affiliations
  • Gato Escondido—Veterinary Clinic, Av. Bombeiros Voluntários n°22B, 2950-209 Palmela, Portugal
  • University of Lisbon (PT)
Corresponding author
Serrano, Isa
Venue
Biomedicines
Publisher
MDPI AG
Published
2023-04-19
Volume
11
Issue
4
Pages
1221
ISSN
2227-9059 (ISSN-L)
OpenAlex
W4366588495
Cited by
71
References
208
Citations by year
2026: 28 · 2025: 20 · 2024: 15 · 2023: 8
FWCI
1.88
Type
journal article
Language
en
Open access
Locations
  • Biomedicines (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords
Pseudomonas aeruginosa, antibiotic resistance, biocide resistance, biocide tolerance, persister cells, biofilm, antimicrobial tolerance, hospital environment, environmental persistence, nosocomial infections, opportunistic pathogens

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