The DOI matches its Crossref record; 128 of the 129 references it cites were found in a registry or an index.
MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES
Abstract
▪ Abstract Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.
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“Most of these associated genes are expressed in microglia,14 the resident immune cells of the brain and mediators of neuroinflammation.15”
From Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease (2015) · cites this paper as [15]
Citations
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ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
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Metadata
- Authors
- González-Scarano, F., & Baltuch, G.
- Affiliations
- Departments of 1Neurology and Microbiology; and 2Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6146;
- University of Pennsylvania (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 1999-03
- Volume
- 22
- Issue
- 1
- Pages
- 219-240
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2146901670
- Cited by
- 984
- References
- 129
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 18 · 2021: 25 · 2020: 15 · 2019: 25 · 2018: 37 · 2017: 37 · 2016: 23 · 2015: 40 · 2014: 32 · 2013: 38 · 2012: 51
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS35743, NS 27405, R01NS035743)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- microglia, neuroinflammation, neurodegeneration, multiple sclerosis, Alzheimer's disease, central nervous system immunity, viral persistence, neuroprotection
- MeSH terms
- Alzheimer Disease, Animals, Central Nervous System Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, HIV Infections, Microglia
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