Cited by 984Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsMultiple Sclerosis Research Studies

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MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

González-Scarano, F., Baltuch, Gordon·1999·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.22.1.219

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Abstract

▪ Abstract Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degeneration as well as protecting the CNS. In entities like human immunodeficiency virus (HIV) infection of the nervous system, microglia are also critical to viral persistence. In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease.

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Authors: González-Scarano, F., & Baltuch, G.
Affiliations: Departments of 1Neurology and Microbiology; and 2Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-6146;
University of Pennsylvania (US)
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 1999-03
Volume: 22
Issue: 1
Pages: 219-240
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev.neuro.22.1.219
OpenAlex: W2146901670
Cited by: 984
References: 129
Citations by year: 2026: 2 · 2025: 5 · 2024: 12 · 2023: 20 · 2022: 18 · 2021: 25 · 2020: 15 · 2019: 25 · 2018: 37 · 2017: 37 · 2016: 23 · 2015: 40 · 2014: 32 · 2013: 38 · 2012: 51
FWCI: 4.95
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (NS35743, NS 27405, R01NS035743)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: microglia, neuroinflammation, neurodegeneration, multiple sclerosis, Alzheimer's disease, central nervous system immunity, viral persistence, neuroprotection
MeSH terms: Alzheimer Disease, Animals, Central Nervous System Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, HIV Infections, Microglia

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MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

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