The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Neurobiology of Feeding and Energy Expenditure
Abstract
Significant advancements have been made in the past century regarding the neuronal control of feeding behavior and energy expenditure. The effects and mechanisms of action of various peripheral metabolic signals on the brain have become clearer. Molecular and genetic tools for visualizing and manipulating individual components of brain homeostatic systems in combination with neuroanatomical, electrophysiological, behavioral, and pharmacological techniques have begun to elucidate the molecular and neuronal mechanisms of complex feeding behavior and energy expenditure. This review highlights some of these advancements that have led to the current understanding of the brain's involvement in the acute and chronic regulation of energy homeostasis.
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“Increasing body weight above healthy lean levels results in changes in glucose metabolism, insulin sensitivity and hormones, such as leptin, ghrelin, NPY, orexin and hypocretin, [GLP-1] which, in turn, regulate appetite and energy homeostasis”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Gao & Horvath, 2007
In the citing paper
“Specific hypothalamic nuclei, which sense nutrients and modify energy intake and expenditure to maintain a balance, are responsible for regulating this intake ([48](#B48)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [48]
In the citing paper
“These neurons are well known to be involved in feeding and food reward processing [18, 19].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [19]
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Cited by
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The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
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Metadata
- Authors
- Gao, Q., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Section of Comparative Medicine and Departments of 2Neurobiology and 3Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520;,
- ORCID
- Gao, Qian
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2007-07-01
- Volume
- 30
- Issue
- 1
- Pages
- 367-398
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2124738442
- Cited by
- 346
- References
- 221
- Citations by year
- 2025: 6 · 2024: 8 · 2023: 4 · 2022: 15 · 2021: 14 · 2020: 20 · 2019: 11 · 2018: 20 · 2017: 15 · 2016: 34 · 2015: 21 · 2014: 22 · 2013: 33 · 2012: 22
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG022880, AG-022880)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 060711, DK074386, R01DK074386, R01DK060711)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- feeding behavior, energy expenditure, energy homeostasis
- MeSH terms
- Animals, Appetite Regulation, Energy Metabolism, Feeding Behavior, Hormones, Humans, Hypothalamus, Motivation, Neural Pathways, Leptin, Melanocortins
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