Neurobiology of Feeding and Energy Expenditure

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924

Food reward: brain substrates of wanting and liking

Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637

Anatomy and regulation of the central melanocortin system

Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583

The role of depot fat in the hypothalamic control of food intake in the rat

Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, J., Kanarek, R. B., & Maratos–Flier, E. (1996) · Nature · doi:10.1038/380243a0 · Cited by 1,320

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289

NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS

Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature · doi:10.1038/372186a0 · Cited by 1,252

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157

Mice lacking melanin-concentrating hormone are hypophagic and lean

Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., & Maratos–Flier, E. (1998) · Nature · doi:10.1038/25341 · Cited by 1,152

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107

How can drug addiction help us understand obesity?

Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089

Expression of ghrelin receptor mRNA in the rat and the mouse brain

Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074

Hypothalamic lesions and adiposity in the rat

Hetherington, A. W., & Ranson, S. W. (1940) · The Anatomical Record · doi:10.1002/ar.1090780203 · Cited by 1,028

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Erickson, J. C., Clegg, K. E., & Palmiter, R. D. (1996) · Nature · doi:10.1038/381415a0 · Cited by 1,016

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · cited 1×

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · cited 12×

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience · doi:10.1038/nn1073 · Cited by 896

Brain Reward Circuitry

Wise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

Mercer, J. G., Hoggard, N., Williams, L. M., Lawrence, C. B., Hannah, L. T., & Trayhurn, P. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00473-5 · Cited by 881

Ghrelin controls hippocampal spine synapse density and memory performance

Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

Baumann, H., Morella, K. K., White, D. W., Dembski, M., Bailon, P., Kim, H., Lai, C. F., & Tartaglia, L. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8374 · Cited by 827

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

Elias, C. F., Lee, C., Kelly, J., Aschkenasi, C. J., Ahima, R. S., Couceyro, P. R., Kuhar, M. J., Saper, C. B., & Elmquist, J. K. (1998) · Neuron · doi:10.1016/s0896-6273(00)80656-x · Cited by 809

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800

The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

Broberger, C., Johansen, J., Johansson, C., Schalling, M., & Hökfelt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15043 · Cited by 798

Activation of Downstream Signals by the Long Form of the Leptin Receptor

Banks, A. S., Davis, S. M., Bates, S. H., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14563 · Cited by 797

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781

To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness

Willie, J. T., Chemelli, R. M., Sinton, C. M., & Yanagisawa, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.429 · Cited by 778

AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 777

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

Håkansson, M., Brown, H., Ghilardi, N., Skoda, R. C., & Meister, B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00559.1998 · Cited by 741

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

Münzberg, H., Flier, J. S., & Bjørbæk, C. (2004) · Endocrinology · doi:10.1210/en.2004-0726 · Cited by 737

Multiple neural systems controlling food intake and body weight

Berthoud, H.-R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00014-3 · Cited by 725

The physiology of motivation.

Stellar, E. (1954) · Psychological Review · doi:10.1037/h0060347 · Cited by 672

Localization of a "Feeding Center" in the Hypothalamus of the Rat

Anand, B. K., & Brobeck, J. R. (1951) · Experimental Biology and Medicine · doi:10.3181/00379727-77-18766 · Cited by 670

Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus

Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651

Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers

Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

Cowley, M. A., Pronchuk, N., Fan, W., Dinulescu, D. M., Colmers, W. F., & Cone, R. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80829-6 · Cited by 612

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

Willesen, M. G., Kristensen, P., & Rømer, J. (1999) · Neuroendocrinology · doi:10.1159/000054491 · Cited by 605

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis

Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Dl, M., & Low, M. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801913 · Cited by 591

Key enzyme in leptin-induced anorexia

Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585

Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms

Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576

Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris ‐Leucoagglutinin study in the rat

Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480103 · Cited by 565

Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase

Kim, M., Park, J., NamKoong, C., Jang, P., Ryu, J., Song, H.-S., Yun, J.-Y., Nam‐Goong, I. S., Ha, J., Park, I.-S., et al. (2004) · Nature Medicine · doi:10.1038/nm1061 · Cited by 527

The efferent connections of the ventromedial nucleus of the hypothalamus of the rat,

Saper, C. B., Swanson, L. W., & Cowan, W. M. (1976) · The Journal of Comparative Neurology · doi:10.1002/cne.901690403 · Cited by 516

The effects of lesions in the hypothalamus in parabiotic rats

Hervey, G. R. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006145 · Cited by 512

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

Horváth, T. L., Diano, S., & van den Pol, A. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01072.1999 · Cited by 508

Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus

Sahu, A., Kalra, P. S., & Kalra, S. P. (1988) · Peptides · doi:10.1016/0196-9781(88)90013-7 · Cited by 503

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495

Afferents to the Ventrolateral Preoptic Nucleus

Chou, T. C., Bjørkum, A. A., Gaus, S. E., Lu, J., Scammell, T. E., & Saper, C. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00977.2002 · Cited by 493

Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase

Kola, B., Hubina, E., Tucci, S. A., Kirkham, T. C., García, E., Mitchell, S. E., Williams, L. M., Hawley, S. A., Hardie, D. G., Grossman, A. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500175200 · Cited by 485

Hypothalamic sensing of fatty acids

Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478

Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System

Li, Y., Gao, X., Sakurai, T., & van den Pol, A. N. (2002) · Neuron · doi:10.1016/s0896-6273(02)01132-7 · Cited by 476

Glucoreceptors Controlling Feeding and Blood Glucose: Location in the Hindbrain

Ritter, R. C., Slusser, P. G., & Stone, S. L. (1981) · Science · doi:10.1126/science.6264602 · Cited by 470

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

Toshinai, K., Date, Y., Murakami, N., Shimada, M., Mondal, M. S., Shimbara, T., Guan, J., Wang, Q., Funahashi, H., Sakurai, T., et al. (2003) · Endocrinology · doi:10.1210/en.2002-220788 · Cited by 470

Experimental Hypothalamic Hyperphagia in the Albino Rat.

Brobeck, J. R., Tepperman, J., & Long, C. N. H. (1943) · Europe PMC (PubMed Central) · Cited by 469

Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.010 · Cited by 468

IRS-2 pathways integrate female reproduction and energy homeostasis

Burks, D. J., de Mora, J. F., Schubert, M., Withers, D. J., Myers, M. G., Towery, H. H., Altamuro, S. L., Flint, C. L., & White, M. F. (2000) · Nature · doi:10.1038/35030105 · Cited by 462

The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms

Gooley, J. J., Schomer, A., & Saper, C. B. (2006) · Nature Neuroscience · doi:10.1038/nn1651 · Cited by 453

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

Lawrence, C. B., Snape, A. C., Baudoin, F., & Luckman, S. M. (2002) · Endocrinology · doi:10.1210/endo.143.1.8561 · Cited by 443

Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D. (2004) · Nature Neuroscience · doi:10.1038/nn1226 · Cited by 435

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430

Chronically Decerebrate Rats Demonstrate Satiation But Not Bait Shyness

Grill, H. J., & Norgren, R. (1978) · Science · doi:10.1126/science.663655 · Cited by 423

Modulation of Brain Reward Circuitry by Leptin

Fulton, S. E., Woodside, B. C., & Shizgal, P. (2000) · Science · doi:10.1126/science.287.5450.125 · Cited by 421

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C. S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C. A., Roberts, J. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1525 · Cited by 416

The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities

Song, M. M., & Shuai, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35056 · Cited by 396

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G. (2002) · Endocrinology · doi:10.1210/endo.143.1.8589 · Cited by 395 · cited 3×

The Neuroanatomical Axis for Control of Energy Balance

Grill, H. J., & Kaplan, J. M. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0224 · Cited by 395

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385

Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

Saito, Y., Cheng, M., Leslie, F. M., & Civelli, O. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1191 · Cited by 381

Mitochondrial uncoupling proteins in the cns: in support of function and survival

Andrews, Z. B., Diano, S., & Horváth, T. L. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1767 · Cited by 374

Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats

Smith, G. P., Jerome, C., & Norgren, R. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.249.5.r638 · Cited by 373

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007439200 · Cited by 364

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue Receptors

McKee, K. K., Palyha, O. C., Feighner, S. D., Hreniuk, D. L., Tan, C. P., Phillips, M. S., Smith, R. G., der Ploeg, L. H. T. V., & Howard, A. D. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9908 · Cited by 358

Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

Baskin, D. G., Breininger, J. F., & Schwartz, M. W. (1999) · Diabetes · doi:10.2337/diabetes.48.4.828 · Cited by 351

Effects of parabiosis of normal with genetically diabetic mice

Coleman, D., & Hummel, K. P. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.5.1298 · Cited by 346

Steroidogenic Factor 1: an Essential Mediator of Endocrine Development

Parker, K. L. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.19 · Cited by 346

Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism

Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action1This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998.1

Dube, M. G., Kalra, S. P., & Kalra, P. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01824-7 · Cited by 335

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

Plum, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27123 · Cited by 326

Regulation of Food Intake and Obesity

Mayer, J., & Thomas, D. W. (1967) · Science · doi:10.1126/science.156.3773.328 · Cited by 319

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Kim, E. K., Miller, I., Aja, S. M., Landree, L. E., Pinn, M. L., McFadden, J. M., Kuhajda, F. P., Moran, T. H., & Ronnett, G. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 313

Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting

Sternson, S. M., Shepherd, G. M., & Friedman, J. M. (2005) · Nature Neuroscience · doi:10.1038/nn1550 · Cited by 307

Hyperphagic Effects of Brainstem Ghrelin Administration

Faulconbridge, L. F., Cummings, D. E., Kaplan, J. M., & Grill, H. J. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2260 · Cited by 307

Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations

Horváth, T. L., Bechmann, I., Naftolin, F. N., Kalra, S. P., & Léránth, C. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00184-4 · Cited by 301

Leptin Receptor (OB-R) Signaling

White, D. W., Kuropatwinski, K. K., Devos, R., Baumann, H., & Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4065 · Cited by 295

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2

Coppola, A., Liu, Z.-W., Andrews, Z. B., Paradis, E., Roy, M.-C., Friedman, J. M., Ricquier, D., Richard, D., Horvath, T. L., Gao, X.-B., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.002 · Cited by 295

Mushroom bodies of the cockroach: Their participation in place memory

Mizunami, M., Weibrecht, J. M., & Strausfeld, N. J. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981228)402:4 · Cited by 289

Knockout Mice Lacking Steroidogenic Factor 1 Are a Novel Genetic Model of Hypothalamic Obesity

Majdič, G., Young, M. J., Gómez-Sánchez, E. P., Anderson, P., Szczepaniak, L. S., Dobbins, R. L., McGarry, J., & Parker, K. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8652 · Cited by 289

Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse

Wilding, J. P. H., Gilbey, S. G., Bailey, C. J., Batt, R. A., Williams, G., Ghatei, M. A., & Bloom, S. R. (1993) · Endocrinology · doi:10.1210/endo.132.5.7682936 · Cited by 285

Reward without dopamine

Cannon, C. M., & Palmiter, R. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10827.2003 · Cited by 280

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

Grill, H. J., Ginsberg, A. B., Seeley, R. J., & Kaplan, J. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10128.1998 · Cited by 277

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

Zhang, E. E., Chapeau, E. A., Hagihara, K., & Feng, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405041101 · Cited by 270

Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms

García‐Segura, L. M., Chowen, J. A., Párducz, Á., & Naftolin, F. N. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90042-6 · Cited by 269

The projections of the dorsomedial hypothalamic nucleus in the rat

Horst, G. J. T., & Luiten, P. G. M. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90038-9 · Cited by 269

The Central Melanocortin System and the Integration of Short- and Long-term Regulators of Energy Homeostasis

Ellacott, K. L. J. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.395 · Cited by 260

Orexin-induced food intake involves neuropeptide Y pathway

Yamanaka, A., Kunii, K., Nambu, T., Tsujino, N., Sakai, A., Matsuzaki, I., Miwa, Y., Goto, K., & Sakurai, T. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02043-6 · Cited by 258

A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

Zhao, A. Z., Huan, J.-N., Gupta, S., Pal, R., & Sahu, A. (2002) · Nature Neuroscience · doi:10.1038/nn885 · Cited by 242

Feeding behavior in dopamine-deficient mice

Szczypka, M. S., Rainey, M. A., Kim, D. S., Alaynick, W. A., Marck, B. T., Matsumoto, A. M., & Palmiter, R. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12138 · Cited by 242

Afferent signals regulating food intake

Bray, G. A. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000422 · Cited by 241

Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity

Boston, B. A., Blaydon, K. M., Varnerin, J. P., & Cone, R. D. (1997) · Science · doi:10.1126/science.278.5343.1641 · Cited by 239

Retention of embryonic features by an adult neuronal system capable of plasticity: polysialylated neural cell adhesion molecule in the hypothalamo-neurohypophysial system.

Theodosis, D. T., Rougon, G. N., & Poulain, D. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5494 · Cited by 238

A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance

Lee, Y. S., Challis, B. G., Thompson, D. A., Yeo, G. S. H., Keogh, J. M., Madonna, M. E., Wraight, V., Sims, M., Vatin, V., Meyre, D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.006 · Cited by 235

Monitoring of stored and available fuel by the CNS: implications for obesity

Seeley, R. J., & Woods, S. C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1245 · Cited by 233

The Mitogenic and Antiapoptotic Actions of Ghrelin in 3T3-L1 Adipocytes

Kim, M., Yoon, C.-Y., Jang, P., Park, Y. J., Shin, C. S., Park, H. S., Ryu, J.-W., Pak, Y. K., Park, J. Y., Lee, K., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0459 · Cited by 232

Neural network of glucose monitoring system

Oomura, Y., & Yoshimatsu, H. (1984) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(84)90033-x · Cited by 230

The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation

Bellinger, L. L., & Bernardis, L. L. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00756-4 · Cited by 228

Physiological Properties of Hypothalamic MCH Neurons Identified with Selective Expression of Reporter Gene after Recombinant Virus Infection

van den Pol, A. N., Acuna, C., Clark, K. R., & Ghosh, P. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00251-x · Cited by 223

Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance

Obici, S., & Rossetti, L. (2003) · Endocrinology · doi:10.1210/en.2003-0999 · Cited by 222

Adiposity signals and food reward: expanding the CNS roles of insulin and leptin

Figlewicz, D. P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00602.2002 · Cited by 221

Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats

Pocai, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26640 · Cited by 211

Localization of Leptin Receptor in the Human Brain

Couce, M., Burguera, B. G., Parisi, J. E., Jensen, M. D., & Lloyd, R. V. (2008) · Neuroendocrinology · doi:10.1159/000127232 · Cited by 205

Coexistence of neuropeptide Y and somatostatin in rat and human cortical and rat hypothalamic neurons

Chronwall, B. M., Chase, T. N., & O’Donohue, T. L. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90164-2 · Cited by 205

AMP-activated protein kinase: balancing the scales

Carling, D. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.017 · Cited by 202

Input organization and plasticity of hypocretin neurons

Horváth, T. L., & Gao, X. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.003 · Cited by 198

Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats

Torrealba, F., Yanagisawa, M., & Saper, C. B. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00238-0 · Cited by 195

A role for β-melanocyte-stimulating hormone in human body-weight regulation

Biebermann, H., Castañeda, T. R., van Landeghem, F. K. H., von Deimling, A., Escher, F., Brabant, G. E., Hebebrand, J., Hinney, A., Tschöp, M. H., Grüters, A., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.007 · Cited by 192

Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus

Gao, X., & van den Pol, A. N. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0237b.x · Cited by 186

The Role of the Dorsal Vagal Complex and the Vagus Nerve in Feeding Effects of Melanocortin-3/4 Receptor Stimulation

Williams, D. L., Kaplan, J. M., & Grill, H. J. (2000) · Endocrinology · doi:10.1210/endo.141.4.7410 · Cited by 182

Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria Predict Thermal Synapses in Homeostatic Centers

Horvath, T. L., Warden, C. H., Hajós, M., Lombardi, A., Goglia, F., & Diano, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10417.1999 · Cited by 181

Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus

Mondal, M. S., Date, Y., Yamaguchi, H., Toshinai, K., Tsuruta, T., Kangawa, K., & Nakazato, M. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.08.038 · Cited by 181

Leptin Sensitive Neurons in the Hypothalamus

Baskin, D. S., Hahn, T. P., & Schwartz, M. D. (1999) · Hormone and Metabolic Research · doi:10.1055/s-2007-978751 · Cited by 172

Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus

Tannenbaum, G. S., Lapointe, M., Beaudet, A., & Howard, A. D. (1998) · Endocrinology · doi:10.1210/endo.139.10.6330 · Cited by 169

Development of Growth Hormone Secretagogues

Smith, R. G. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0019 · Cited by 168

Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior

Sahu, A., Kalra, S. P., Crowley, W. R., & Kalra, P. S. (1988) · Brain Research · doi:10.1016/0006-8993(88)90710-x · Cited by 167

GABA Release from Proopiomelanocortin Neurons

Hentges, S. T., Nishiyama, M., Overstreet‐Wadiche, L., Stenzel‐Poore, M. P., Williams, J. T., & Low, M. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3952-03.2004 · Cited by 162

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis.

Horváth, T. L., Naftolin, F. N., Kalra, S. P., & Leranth, C. (1992) · Endocrinology · doi:10.1210/endo.131.5.1425443 · Cited by 161

Localization of leptin receptor mRNA expression in mouse brain

Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., & Storlien, L. (1996) · NeuroReport · doi:10.1097/00001756-199611040-00045 · Cited by 160 · cited 1×

Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts

Chua, S. C., Koutras, I. K., Han, L., Liu, S.-M., Kay, J., Young, S. J., Chung, W. K., & Leibel, R. L. (1997) · Genomics · doi:10.1006/geno.1997.4962 · Cited by 158

Feedback Inhibition of Leptin Receptor/Jak2 Signaling via Tyr1138 of the Leptin Receptor and Suppressor of Cytokine Signaling 3

Dunn, S. L., Björnholm, M., Bates, S. H., Chen, Z., Seifert, M. M., & Myers, M. G. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0353 · Cited by 157

Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats

Jain, M. R., Horváth, T. L., Kalra, P. S., & Kalra, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00102-0 · Cited by 154

Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

McCrimmon, R. J., Fan, X., Ding, Y., Zhu, W., Jacob, R. J., & Sherwin, R. S. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1953 · Cited by 153

The Forebrain Is Not Essential for Sympathoadrenal Hyperglycemic Response to Glucoprivation

DiRocco, R. J., & Grill, H. J. (1979) · Science · doi:10.1126/science.451558 · Cited by 150

Cell Biology of the Ghrelin Receptor

Camiña, J. P. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01379.x · Cited by 147

Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.

Harrold, J. A., Widdowson, P. S., & Williams, G. H. (1999) · Diabetes · doi:10.2337/diabetes.48.2.267 · Cited by 145

Role of Neuronal Energy Status in the Regulation of Adenosine 5′-Monophosphate-Activated Protein Kinase, Orexigenic Neuropeptides Expression, and Feeding Behavior

Lee, K., Li, B., Xi, X., Suh, Y., & Martin, R. J. (2004) · Endocrinology · doi:10.1210/en.2004-0968 · Cited by 138

Dopamine is required for hyperphagia in Lepob/ob mice

Szczypka, M. S., Rainey, M. A., & Palmiter, R. D. (2000) · Nature Genetics · doi:10.1038/75484 · Cited by 134

The Effect of Leptin Is Enhanced by Microinjection Into the Ventromedial Hypothalamus

Jacob, R. J., Dziura, J. D., Medwick, M. B., Leone, P., Caprio, S., During, M. J., Shulman, G. I., & Sherwin, R. (1997) · Diabetes · doi:10.2337/diab.46.1.150 · Cited by 134

Brain‐derived neurotrophic factor (BDNF) regulates glucose and energy metabolism in diabetic mice

Nakagawa, T., Ono‐Kishino, M., Sugaru, E., Yamanaka, M., Taiji, M., & Noguchi, H. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.290 · Cited by 133

C75, a Fatty Acid Synthase Inhibitor, Modulates AMP-activated Protein Kinase to Alter Neuronal Energy Metabolism

Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C. A., Witters, L. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310991200 · Cited by 133

Differential effects of melanocortin peptides on neural melanocortin receptors.

Adan, R. A. H., Cone, R. D., Burbach, J. P. H., & Gispen, W. H. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09867-0 · Cited by 130

Reorganization of the Dendritic Trees of Oxytocin and Vasopressin Neurons of the Rat Supraoptic Nucleus during Lactation

Stern, J. E., & Armstrong, W. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-00841.1998 · Cited by 130

Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation

Guan, J.-L., Uehara, K., Lu, S., Wang, Q.-P., Funahashi, H., Sakurai, T., Yanagizawa, M., & Shioda, S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802155 · Cited by 124

Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus

Komori, T., Morikawa, Y., Nanjo, K., & Senba, E. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.066 · Cited by 122

Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons

Alon, T., & Friedman, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1203-05.2006 · Cited by 121

Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow

Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000048342.54392.40 · Cited by 120

Fasting Activates the Nonhuman Primate Hypocretin (Orexin) System and Its Postsynaptic Targets

Diano, S., Horvath, B., Urbanski, H. F., Sotonyi, P., & Horvath, T. L. (2003) · Endocrinology · doi:10.1210/en.2003-0274 · Cited by 119

Weighing the Role of Hypothalamic Feeding Neurotransmitters

van den Pol, A. N. (2003) · Neuron · doi:10.1016/s0896-6273(03)00809-2 · Cited by 114

Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding

Sotak, B. N., Hnasko, T. S., Robinson, S., Kremer, E. J., & Palmiter, R. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.08.053 · Cited by 113

Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice

Tsuchida, A., Nonomura, T., Nakagawa, T., Itakura, Y., Ono‐Kishino, M., Yamanaka, M., Sugaru, E., Taiji, M., & Noguchi, H. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00206.x · Cited by 105

Evidence for the Existence of Distinct Central Appetite, Energy Expenditure, and Ghrelin Stimulation Pathways as Revealed by Hypothalamic Site-Specific Leptin Gene Therapy

Bagnasco, M., Dube, M. G., Kalra, P. S., & Kalra, S. P. (2002) · Endocrinology · doi:10.1210/en.2002-220505 · Cited by 103

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

Clifton, P. G., Vickers, S. P., & Somerville, E. M. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.3.502 · Cited by 100

CNS Melanocortin System Involvement in the Regulation of Food Intake

Benoit, S. C., Schwartz, M. W., Baskin, D. G., Woods, S. C., & Seeley, R. J. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1588 · Cited by 100

Evidence for Seasonal Plasticity in the Gonadotropin-Releasing Hormone (GnRH) System of the Ewe: Changes in Synaptic Inputs onto GnRH Neurons

Xiong, J.-J., Karsch, F. J., & Lehman, M. N. (1997) · Endocrinology · doi:10.1210/endo.138.3.5000 · Cited by 96

Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

Tritos, N. A., Mastaitis, J. W., Kokkotou, E. G., & Maratos–Flier, E. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02066-2 · Cited by 93

Evidence for a physiological role for CCK in the regulation of food intake in mice

Silver, A. J., Flood, J. F., Song, A. M., & Morley, J. E. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.3.r646 · Cited by 92

Little and often: Ingestive behavior patterns following hippocampal lesions in rats.

Clifton, P. G., Vickers, S. P., & Somerville, E. M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.3.502 · Cited by 92

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis [published erratum appears in Endocrinology 1996 Feb;137(2):532]

Horváth, T. L. (1992) · Endocrinology · doi:10.1210/en.131.5.2461 · Cited by 91

Antisense to NPY-Y1 demonstrates that Y1 receptors in the hypothalamus underlie NPY hypothermia and feeding in rats

Lopez-Valpuesta, F. J., Nyce, J. W., Griffin-Biggs, T. A., Ice, J. C., & Myers, R. D. (1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0130 · Cited by 78

Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus

Davis, A. M., Seney, M. L., Stallings, N. R., Zhao, L., Parker, K. L., & Tobet, S. A. (2004) · Journal of Neurobiology · doi:10.1002/neu.20030 · Cited by 76

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Kennedy, A. R., Todd, J. F., Stanley, S., Abbott, C. R., Small, C. J., Ghatei, M. A., & Bloom, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.7.8374 · Cited by 71

Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects

Mazzocchi, G., Neri, G., Ruciński, M., Rebuffat, P., Spinazzi, R., Malendowicz, L. K., & Nussdorfer, G. G. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.011 · Cited by 70

Intrahypothalamic connections: An electron microscopic study in the rat

Z�borszky, L., & Makara, G. B. (1979) · Experimental Brain Research · doi:10.1007/bf00235668 · Cited by 70

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Fuxé, K., Rivera, A., Jacobsen, K. X., H�istad, M., Leo, G., Horváth, T. L., Staines, W. A., de la Calle, A., & Agnati, L. F. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0158-3 · Cited by 69

Structural dynamics of neural plasticity in the supraoptic nucleus of the rat hypothalamus during dehydration and rehydration

Miyata, S., Nakashima, T., & Kiyohara, T. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90057-4 · Cited by 67

Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance

Zheng, H., Patterson, L. M., Morrison, C. D., Banfield, B. W., Randall, J. A., Browning, K. N., Travagli, R. A., & Berthoud, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.055 · Cited by 66

Neurological dissociation of gastrointestinal and metabolic contributions to meal size control.

Seeley, R. J., Grill, H. J., & Kaplan, J. M. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.2.347 · Cited by 65

Direct Excitation of Hypocretin/Orexin Cells by Extracellular ATP at P2X Receptors

Wollmann, G., Acuna, C., & van den Pol, A. N. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00035.2005 · Cited by 64

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GRILL, H. J., & Kaplan, J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801917 · Cited by 64

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Grill, H. J., Markison, S., Ginsberg, A. B., & Kaplan, J. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02193-4 · Cited by 63

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Bailey, Englehardt, V., Leng, G., Smith, & Dickson, S. L. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00398.x · Cited by 61

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Travers, S. P., & Norgren, R. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1372 · Cited by 61

Non‐production of hypothalamic obesity in the rat by lesions rostral or dorsal to the ventro‐medial hypothalamic nuclei

Hetherington, A. W. (1944) · The Journal of Comparative Neurology · doi:10.1002/cne.900800104 · Cited by 60

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Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873

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Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875

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Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 749

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Abizaid, A. B., Gao, Q., & Horváth, T. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.025 · Cited by 122

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Sohn, J., Elmquist, J. K., & Williams, K. W. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.05.003 · Cited by 282

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